Inflammation and immune dysfunction in Parkinson disease

Nature reviews. Immunology, Journal Year: 2022, Volume and Issue: 22(11), P. 657 - 673

Published: March 4, 2022

Language: Английский

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Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders

Nutrients, Journal Year: 2021, Volume and Issue: 13(6), P. 2099 - 2099

Published: June 19, 2021

Emerging evidence indicates that gut microbiota is important in the regulation of brain activity and cognitive functions. Microbes mediate communication among metabolic, peripheral immune, central nervous systems via microbiota–gut–brain axis. However, it not well understood how microbiome neurons mutually interact or these interactions affect normal functioning cognition. We summarize mechanisms whereby regulate production, transportation, neurotransmitters. also discuss dysbiosis affects function, especially neurodegenerative diseases such as Alzheimer’s disease Parkinson’s disease.

Language: Английский

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The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders

Pharmacological Research, Journal Year: 2021, Volume and Issue: 172, P. 105840 - 105840

Published: Aug. 24, 2021

Emerging evidence indicates that the gut microbiota play a crucial role in bidirectional communication between and brain suggesting microbes may shape neural development, modulate neurotransmission affect behavior, thereby contribute to pathogenesis and/or progression of many neurodevelopmental, neuropsychiatric, neurological conditions. This review summarizes recent data on microbiota-gut-brain axis pathophysiology neuropsychiatric disorders including depression, anxiety, schizophrenia, autism spectrum disorders, Parkinson's disease, migraine, epilepsy. Also, involvement co-existing with conditions is highlighted. We discuss from both vivo preclinical experiments clinical reports including: (1) studies germ-free animals, (2) exploring composition animal models diseases or humans, (3) evaluating effects probiotic, prebiotic antibiotic treatment as well (4) fecal transplantation.

Language: Английский

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Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer

Nature Medicine, Journal Year: 2022, Volume and Issue: 28(2), P. 315 - 324

Published: Feb. 1, 2022

Language: Английский

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The pathogenesis of Parkinson's disease

The Lancet, Journal Year: 2024, Volume and Issue: 403(10423), P. 293 - 304

Published: Jan. 1, 2024

Language: Английский

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Role of microbiota-derived short-chain fatty acids in nervous system disorders

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 139, P. 111661 - 111661

Published: May 8, 2021

During the past decade, accumulating evidence from research highlights suggested effects of bacterial communities human gut microbiota and their metabolites on health disease. In this regard, microbiota-derived receptors, beyond immune system, maintain metabolism homeostasis, which is essential to host's by balancing utilization intake nutrients. It has been shown that dysbiosis can cause pathology altered metabolites' formation, resulting in dysregulation system metabolism. The short-chain fatty acids (SCFAs), such as butyrate, acetate, succinate, are produced due fermentation process bacteria gut. noted remodeling associated with pathophysiology several neurological disorders, Alzheimer's disease, multiple sclerosis, Parkinson's amyotrophic lateral stress, anxiety, depression, autism, vascular dementia, schizophrenia, stroke, neuromyelitis optica spectrum among others. This review will discuss current most significant studies dealing some SCFAs microbial selected disorders.

Language: Английский

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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Feb. 16, 2024

Abstract The human gastrointestinal tract is populated with a diverse microbial community. vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect biology, including health maintenance, development, aging, disease. advent new sequencing technologies culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations shed light on microbiome–host interactions. Evidence unveiled bidirectional communication between central nervous system, referred as “microbiota–gut–brain axis”. microbiota–gut–brain axis represents an important regulator glial functions, making it actionable target ameliorate development progression neurodegenerative diseases. In this review, we discuss mechanisms As provides essential cues microglia, astrocytes, oligodendrocytes, examine communications microbiota these cells during healthy states Subsequently, diseases using metabolite-centric approach, while also examining role microbiota-related neurotransmitters hormones. Next, targeting intestinal barrier, blood–brain meninges, peripheral immune system counteract dysfunction neurodegeneration. Finally, conclude by assessing pre-clinical clinical evidence probiotics, prebiotics, fecal transplantation A thorough comprehension will foster effective therapeutic interventions for management

Language: Английский

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Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain

Microbiome, Journal Year: 2022, Volume and Issue: 10(1)

Published: April 29, 2022

Altered intestinal microbiota composition in later life is associated with inflammaging, declining tissue function, and increased susceptibility to age-associated chronic diseases, including neurodegenerative dementias. Here, we tested the hypothesis that manipulating influences development of major comorbidities aging and, particular, inflammation affecting brain retina.

Language: Английский

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The microbiome–gut–brain axis in Parkinson disease — from basic research to the clinic

Nature Reviews Neurology, Journal Year: 2022, Volume and Issue: 18(8), P. 476 - 495

Published: June 24, 2022

Language: Английский

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Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanisms

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Nov. 15, 2022

Abstract Parkinson’s disease (PD) may start in the gut and spread to brain. To investigate role of microbiome, we conducted a large-scale study, at high taxonomic resolution, using uniform standardized methods from end. We enrolled 490 PD 234 control individuals, deep shotgun sequencing fecal DNA, followed by metagenome-wide association studies requiring significance two (ANCOM-BC MaAsLin2) declare association, network analysis identify polymicrobial clusters, functional profiling. Here show that over 30% species, genes pathways tested have altered abundances PD, depicting widespread dysbiosis. PD-associated species form clusters grow or shrink together, some compete. microbiome is permissive, evidenced overabundance pathogens immunogenic components, dysregulated neuroactive signaling, preponderance molecules induce alpha-synuclein pathology, over-production toxicants; with reduction anti-inflammatory neuroprotective factors limiting capacity recover. validate, human findings were observed experimental models; reconcile resolve literature; provide broad foundation wealth concrete testable hypotheses discern PD.

Language: Английский

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