Abnormal choroid plexus, hippocampus, and lateral ventricles volumes as markers of treatment‐resistant major depressive disorder DOI Creative Commons
B. Bravi, Marco Paolini,

Melania Maccario

et al.

Psychiatry and Clinical Neurosciences, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Aim One‐third of patients with major depressive disorder (MDD) do not achieve full remission and have high relapse rates even after treatment, leading to increased medical costs reduced quality life health status. The possible specificity treatment‐resistant depression (TRD) neurobiology is still under investigation, risk factors such as higher inflammatory markers being identified. Given recent findings on the role choroid plexus (ChP) in neuroinflammation hippocampus treatment response, aim present study was evaluate inflammatory‐ trophic‐related differences these regions along ventricular volumes among treatment‐sensitive (TSD), TRD, healthy controls (HCs). Methods ChP, hippocampal, were assessed 197 MDD 58 age‐ sex‐matched HCs. Volumes estimated using FreeSurfer 7.2. Treatment resistance status defined failure respond at least two separate antidepressant treatments. Region interest then compared groups. Results We found ChP TRD TSD Our results also showed lower hippocampal lateral both without Conclusions These corroborate link between neuroinflammation, volume could be considered a putative marker central immune activity. lack significant all region HCs may highlight features possibly providing new insights into specific neurobiological underpinnings this condition.

Language: Английский

Neuroinflammation and schizophrenia – is there a link? DOI Creative Commons
Cristiano Chaves, Serdar Dursun, Massimo Tusconi

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 8, 2024

Keywords: inflammation, schizophrenia, biomarkers, psychiatric genetics, neurobiology, neuroinflammation, psychotic disorders

Language: Английский

Citations

9
The impact of white matter brain lesions on processing speed deficits in systemic lupus erythematosus patients DOI
Anna Wójcicka-Frankiewicz, Mikołaj A. Pawlak, Maciej Piernik

et al.

Lupus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Background The mechanism of cognitive dysfunction in systemic lupus erythematosus (SLE) is still not fully understood. Even though many SLE patients present some neurological dysfunction, including various deficits, neither a specific pattern nor structural changes associated with impairment have been established. Moreover, although prevalent and bothersome, deficits included the most recent diagnostic criteria. Purpose aim this study was to determine relationship between presence white matter lesions (WMLs) diagnosed SLE. Research Design 33 underwent 3 T brain magnetic resonance imagining (MRI) an extensive battery psychological tests, Automated Neuropsychological Assessment Metrics (ANAM) standard pen paper neuropsychological tests. Patients were stratified into two groups based on ( N = 15) or absence 18) WMLs. Psychometric scores compared groups. Results conclusions Significant functions observed. WMLs showed attention executive functions, as well memory comparison group without As measured with: STROOP Test (executive function), Color Trail (CTT) (attention), Californian Verbal Learning (CVLT) (memory), from ANAM tests Procedural Reaction Time (PRT) Code Substitution Delayed (CS_D) Spatial Processing (SP) (visuospatial functions), Tower Puzzle (TP) 2 Choice (2CHRT) Running Memory CPT (RM CPT) Matching Grids (Mat GR) Go/No _Go inhibition (Go/No_Go Go) functions). Additionally, we analyzed volumetric measures derived comprehensive segmentation pipeline recon-all using Freesurfer 5.3. differences identified for following structures’ volumes: right choroid plexus, left lateral ventricle. All these structures had greater volume

Language: Английский

Citations

0
Potential of extracellular vesicle cargo as molecular signals in Schizophrenia: a scoping review DOI Creative Commons

G Shivaprakash,

Smita Shenoy, Dinesh Upadhya

et al.

Schizophrenia, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 12, 2025

Abstract The diagnosis of schizophrenia (SCZ) primarily relies on clinical history and mental status assessments by trained professionals. There has been a search for biomarkers to facilitate laboratory diagnosis. Since extracellular vesicles (EVs) communicate with brain cells can easily cross blood-brain barrier, there is increased interest among experts explore them as potential molecular signals disease detection. A scoping review was conducted provide comprehensive summary the existing literature identify differentially expressed in EVs isolated from SCZ patients. methodological framework outline provided Arksey O’Malley employed conduct this review. systematic using string across four databases, ultimately leading selection 24 relevant studies. Over 1122 biomolecules were identified extracted biological fluids tissues that be categorized RNAs, proteins, metabolites. Among them, 83 validated signals, which included metabolites, circRNAs, lncRNAs, miRNAs, proteins. These found affect cellular receptors intracellular pathways, neurotransmitters, mitochondrial functions, immune-related metabolic could serve

Language: Английский

Citations

0
Toxoplasma gondii, endothelial cells and schizophrenia: is it just a barrier matter? DOI Creative Commons
Victoria Cruz Cavalari, Luiz Fernando Cardoso Garcia, Raffael Massuda

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 10, 2025

Toxoplasma gondii is an obligatory intracellular parasite responsible for causing toxoplasmosis. It estimated that approximately one-third of the world's population has positive serology Acute T. infection often results in subtle symptoms because its nonspecific nature. Owing to immune pressure, parasites tend encyst and persist different tissues organs, such as brain, chronicling infection. While most chronically infected individuals do not develop significant symptoms, can affect central nervous system (CNS), leading range from dizziness behavioral changes. To reach CNS, must overcome blood-brain barrier, which composed primarily endothelial cells. these cells are typically efficient at separating blood elements infection, they only permit parasitic colonization CNS but also contribute inflammatory profile may exacerbate previously established conditions both local systemic levels. An increasing body research demonstrated a potential link between by cellular or humoral response with worsening psychiatric conditions, schizophrenia. Therefore, continually advancing aimed understanding mitigating relationship schizophrenia imperative.

Language: Английский

Citations

0
Improved patient identification by incorporating symptom severity in deep learning using neuroanatomic images in first episode schizophrenia DOI
Wenjing Zhang, Lituan Wang,

Xu‐Sha Wu

et al.

Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Language: Английский

Citations

1
The choroid plexus: A biomarker for schizophrenia? DOI
Maree J. Webster

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 118, P. 366 - 367

Published: March 8, 2024

Language: Английский

Citations

0
Abnormal choroid plexus, hippocampus, and lateral ventricles volumes as markers of treatment‐resistant major depressive disorder DOI Creative Commons
B. Bravi, Marco Paolini,

Melania Maccario

et al.

Psychiatry and Clinical Neurosciences, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Aim One‐third of patients with major depressive disorder (MDD) do not achieve full remission and have high relapse rates even after treatment, leading to increased medical costs reduced quality life health status. The possible specificity treatment‐resistant depression (TRD) neurobiology is still under investigation, risk factors such as higher inflammatory markers being identified. Given recent findings on the role choroid plexus (ChP) in neuroinflammation hippocampus treatment response, aim present study was evaluate inflammatory‐ trophic‐related differences these regions along ventricular volumes among treatment‐sensitive (TSD), TRD, healthy controls (HCs). Methods ChP, hippocampal, were assessed 197 MDD 58 age‐ sex‐matched HCs. Volumes estimated using FreeSurfer 7.2. Treatment resistance status defined failure respond at least two separate antidepressant treatments. Region interest then compared groups. Results We found ChP TRD TSD Our results also showed lower hippocampal lateral both without Conclusions These corroborate link between neuroinflammation, volume could be considered a putative marker central immune activity. lack significant all region HCs may highlight features possibly providing new insights into specific neurobiological underpinnings this condition.

Language: Английский

Citations

0