Wireless, battery-free, and fully implantable electrical neurostimulation in freely moving rodents DOI Creative Commons
Alex Burton, Sang Min Won, Arian Kolahi Sohrabi

et al.

Microsystems & Nanoengineering, Journal Year: 2021, Volume and Issue: 7(1)

Published: Aug. 13, 2021

Abstract Implantable deep brain stimulation (DBS) systems are utilized for clinical treatment of diseases such as Parkinson’s disease and chronic pain. However, long-term efficacy DBS is limited, neuroplastic changes associated therapeutic mechanisms not well understood. Fundamental mechanistic investigation, typically accomplished in small animal models, difficult because the need stimulators that currently require either frequent handling test subjects to charge battery-powered or specialized setups manage tethers restrict experimental paradigms compromise insight. To overcome these challenges, we demonstrate a fully implantable, wireless, battery-free platform allows rodents with capability control parameters digitally real time. The devices able provide over wide range frequencies biphasic pulses constant voltage via low-impedance, surface-engineered platinum electrodes. utilize off-the-shelf components feature ability customize electrodes enable broad utility rapid dissemination. Efficacy system demonstrated readout stimulation-evoked neural activity vivo medial forebrain bundle freely moving rats evoke characteristic head motion 36 days.

Language: Английский

Flexible Electronics and Devices as Human–Machine Interfaces for Medical Robotics DOI
Wenzheng Heng,

Samuel A. Solomon,

Wei Gao

et al.

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(16)

Published: Dec. 12, 2021

Abstract Medical robots are invaluable players in non‐pharmaceutical treatment of disabilities. Particularly, using prosthetic and rehabilitation devices with human–machine interfaces can greatly improve the quality life for impaired patients. In recent years, flexible electronic soft robotics have attracted tremendous attention this field due to their high biocompatibility, functionality, conformability, low‐cost. Flexible on will make a promising alternative conventional rigid devices, which potentially revolutionize paradigm future direction medical terms feedback user experience. review, fundamental components materials, structures, mechanisms human‐machine summarized by renowned applications five primary areas: physical chemical sensing, physiological recording, information processing communication, robotic actuation, stimulation. This review further concludes discussing outlook current challenges these technologies as interface robotics.

Language: Английский

Citations

375

Artificial Intelligence‐Enabled Sensing Technologies in the 5G/Internet of Things Era: From Virtual Reality/Augmented Reality to the Digital Twin DOI Creative Commons
Zixuan Zhang, Feng Wen, Zhongda Sun

et al.

Advanced Intelligent Systems, Journal Year: 2022, Volume and Issue: 4(7)

Published: March 29, 2022

With the development of 5G and Internet Things (IoT), era big data‐driven product design is booming. In addition, artificial intelligence (AI) also emerging evolving by recent breakthroughs in computing power software architectures. this regard, digital twin, analyzing various sensor data with help AI algorithms, has become a cutting‐edge technology that connects physical virtual worlds, which sensors are highly desirable to collect environmental information. However, although existing technologies, including cameras, microphones, inertial measurement units, etc., widely used as sensing elements for applications, high‐power consumption battery replacement them still problem. Triboelectric nanogenerators (TENGs) self‐powered supply feasible platform realizing self‐sustainable low‐power systems. Herein, progress on TENG‐based intelligent systems, is, wearable electronics, robot‐related smart homes, followed prospective future enabled fusion technology, focused on. Finally, how apply systems IoT discussed.

Language: Английский

Citations

302

Additive Manufacturing of Ti3C2‐MXene‐Functionalized Conductive Polymer Hydrogels for Electromagnetic‐Interference Shielding DOI
Ji Liu, Lorcan McKeon, James Garcia

et al.

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(5)

Published: Nov. 16, 2021

The ongoing miniaturization of devices and development wireless implantable technologies demand electromagnetic interference (EMI)-shielding materials with customizability. Additive manufacturing conductive polymer hydrogels favorable conductivity biocompatibility can offer new opportunities for EMI-shielding applications. However, simultaneously achieving high conductivity, design freedom, shape fidelity in 3D printing is still very challenging. Here, an aqueous Ti3 C2 -MXene-functionalized poly(3,4-ethylenedioxythiophene):polystyrene sulfonate ink developed extrusion to create objects arbitrary geometries, a freeze-thawing protocol proposed transform the printed directly into highly robust on both macro- microscale. as-obtained hydrogel exhibits 1525.8 S m-1 at water content up 96.6 wt% also satisfactory mechanical properties flexibility, stretchability, fatigue resistance. Furthermore, use customizable applications demonstrated. easy-to-manufacture approach, along highlighted superior properties, expands potential future represents real breakthrough from current state art.

Language: Английский

Citations

184

Room-temperature high-precision printing of flexible wireless electronics based on MXene inks DOI Creative Commons
Yuzhou Shao,

Lusong Wei,

Xinyue Wu

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: June 9, 2022

Wireless technologies-supported printed flexible electronics are crucial for the Internet of Things (IoTs), human-machine interaction, wearable and biomedical applications. However, challenges to existing printing approaches remain, such as low precision, difficulty in conformal printing, complex ink formulations processes. Here we present a room-temperature direct strategy wireless electronics, where distinct high-performance functional modules (e.g., antennas, micro-supercapacitors, sensors) can be fabricated with high resolution further integrated on various flat/curved substrates. The additive-free titanium carbide (Ti3C2Tx) MXene aqueous inks regulated large single-layer ratio (>90%) narrow flake size distribution, offering metallic conductivity (~6, 900 S cm-1) ultrafine-printed tracks (3 μm line gap 0.43% spatial uniformity) without annealing. In particular, build an all-MXene-printed system capable communication, energy harvesting, smart sensing. This work opens door high-precision additive manufacturing at room temperature.

Language: Английский

Citations

163

Rational Design of Flexible Zn-Based Batteries for Wearable Electronic Devices DOI
Xiao Xiao, Zhiyang Zheng, Xiongwei Zhong

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(3), P. 1764 - 1802

Published: Jan. 30, 2023

The advent of 5G and the Internet Things has spawned a demand for wearable electronic devices. However, lack suitable flexible energy storage system become "Achilles' Heel" Additional problems during transformation battery structure from conventional to also present severe challenge design. Flexible Zn-based batteries, including Zn-ion batteries Zn–air have long been considered promising candidates due their high safety, eco-efficiency, substantial reserve, low cost. In past decade, researchers come up with elaborate designs each portion improve ionic conductivities, mechanical properties, environment adaptabilities, scalable productions. It would be helpful summarize reported strategies compare pros cons facilitate further research toward commercialization batteries. this review, current progress in developing is comprehensively reviewed, electrolytes, cathodes, anodes, discussed terms synthesis, characterization, performance validation. By clarifying challenges design, we methodology previous investigations propose future development. end, paradigm summarized fit burgeoning requirement devices an iterative process, which will benefit development

Language: Английский

Citations

138

Towards translational optogenetics DOI

Akshaya Bansal,

Swati Shikha, Yong Zhang

et al.

Nature Biomedical Engineering, Journal Year: 2022, Volume and Issue: 7(4), P. 349 - 369

Published: Jan. 13, 2022

Language: Английский

Citations

121

Piezoelectric ultrasound energy–harvesting device for deep brain stimulation and analgesia applications DOI Creative Commons
Tao Zhang, Huageng Liang, Zhen Wang

et al.

Science Advances, Journal Year: 2022, Volume and Issue: 8(15)

Published: April 15, 2022

Supplying wireless power is a challenging technical problem of great importance for implantable biomedical devices. Here, we introduce novel piezoelectric ultrasound energy–harvesting device based on Sm-doped Pb(Mg 1/3 Nb 2/3 )O 3 -PbTiO (Sm-PMN-PT) single crystal. The output density this can reach up to 1.1 W/cm 2 in vitro, which 18 times higher than the previous record (60 mW/cm ). After being implanted rat brain, under 1-MHz with safe intensity 212 , as-developed produce an instantaneous effective 280 μW, immediately activate periaqueductal gray brain area. electrophysiological experiments anesthesia and behavioral demonstrate that our wireless-powered well qualified deep stimulation analgesia applications. These encouraging results provide new insights into development devices future.

Language: Английский

Citations

108

Ultrasound-driven in vivo electrical stimulation based on biodegradable piezoelectric nanogenerators for enhancing and monitoring the nerve tissue repair DOI
Ping Wu, Ping Chen, Chao Xu

et al.

Nano Energy, Journal Year: 2022, Volume and Issue: 102, P. 107707 - 107707

Published: Aug. 18, 2022

Language: Английский

Citations

98

Flexible ultrasound-induced retinal stimulating piezo-arrays for biomimetic visual prostheses DOI Creative Commons
Laiming Jiang, Gengxi Lu, Yushun Zeng

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: July 4, 2022

Abstract Electronic visual prostheses, or biomimetic eyes, have shown the feasibility of restoring functional vision in blind through electrical pulses to initiate neural responses artificially. However, existing prostheses predominantly use wired connections electromagnetic waves for powering and data telemetry, which raises safety concerns couples inefficiently miniaturized implant units. Here, we present a flexible ultrasound-induced retinal stimulating piezo-array that can offer an alternative wireless artificial prosthesis approach evoking percepts individuals. The device integrates two-dimensional with 32-pixel electrodes printed circuit board. Each piezo-element be ultrasonically individually activated, thus, spatially reconfigurable electronic patterns dynamically applied via programmable ultrasound beamlines. As proof concept, demonstrate pattern reconstruction ex vivo murine tissue, showing potential this restore functional, life-enhancing people living blindness.

Language: Английский

Citations

94

A wireless and battery-less implant for multimodal closed-loop neuromodulation in small animals DOI
Wei Ouyang, Wei Lu, Yamin Zhang

et al.

Nature Biomedical Engineering, Journal Year: 2023, Volume and Issue: 7(10), P. 1252 - 1269

Published: April 27, 2023

Language: Английский

Citations

74