Advanced Materials,
Journal Year:
2022,
Volume and Issue:
36(43)
Published: Aug. 11, 2022
Abstract
Pressures
generated
by
external
forces
or
internal
body
processes
represent
parameters
of
critical
importance
in
diagnosing
physiological
health
and
anticipating
injuries.
Examples
span
intracranial
hypertension
from
traumatic
brain
injuries,
high
blood
pressure
poor
diet,
pressure‐induced
skin
ulcers
immobility,
edema
congestive
heart
failure.
measured
on
the
soft
surfaces
vital
organs
within
cavities
can
provide
essential
insights
into
patient
status
progression.
Challenges
lie
development
high‐performance
sensors
that
softly
interface
with
biological
tissues
to
enable
safe
monitoring
for
extended
periods
time.
This
review
focuses
recent
advances
mechanically
active
materials
structural
designs
classes
have
proven
uses
these
contexts.
The
discussions
include
applications
such
as
implantable
wearable
systems,
various
unique
capabilities
wireless
continuous
monitoring,
minimally
invasive
deployment,
natural
degradation
biofluids,
and/or
multiplexed
spatiotemporal
mapping.
A
concluding
section
summarizes
challenges
future
opportunities
this
growing
field
biomedical
research.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(6), P. 5211 - 5295
Published: March 9, 2023
Humans
rely
increasingly
on
sensors
to
address
grand
challenges
and
improve
quality
of
life
in
the
era
digitalization
big
data.
For
ubiquitous
sensing,
flexible
are
developed
overcome
limitations
conventional
rigid
counterparts.
Despite
rapid
advancement
bench-side
research
over
last
decade,
market
adoption
remains
limited.
To
ease
expedite
their
deployment,
here,
we
identify
bottlenecks
hindering
maturation
propose
promising
solutions.
We
first
analyze
achieving
satisfactory
sensing
performance
for
real-world
applications
then
summarize
issues
compatible
sensor-biology
interfaces,
followed
by
brief
discussions
powering
connecting
sensor
networks.
Issues
en
route
commercialization
sustainable
growth
sector
also
analyzed,
highlighting
environmental
concerns
emphasizing
nontechnical
such
as
business,
regulatory,
ethical
considerations.
Additionally,
look
at
future
intelligent
sensors.
In
proposing
a
comprehensive
roadmap,
hope
steer
efforts
towards
common
goals
guide
coordinated
development
strategies
from
disparate
communities.
Through
collaborative
efforts,
scientific
breakthroughs
can
be
made
sooner
capitalized
betterment
humanity.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(16), P. 9982 - 10078
Published: Aug. 5, 2023
Recent
advancements
in
wearable
electronics
offer
seamless
integration
with
the
human
body
for
extracting
various
biophysical
and
biochemical
information
real-time
health
monitoring,
clinical
diagnostics,
augmented
reality.
Enormous
efforts
have
been
dedicated
to
imparting
stretchability/flexibility
softness
electronic
devices
through
materials
science
structural
modifications
that
enable
stable
comfortable
of
these
curvilinear
soft
body.
However,
optical
properties
are
still
early
stages
consideration.
By
incorporating
transparency,
visual
from
interfacing
biological
systems
can
be
preserved
utilized
comprehensive
diagnosis
image
analysis
techniques.
Additionally,
transparency
provides
imperceptibility,
alleviating
reluctance
wear
device
on
exposed
skin.
This
review
discusses
recent
advancement
transparent
a
way
includes
materials,
processing,
devices,
applications.
Materials
discussed
regarding
their
characteristics,
synthesis,
engineering
strategies
property
enhancements.
We
also
examine
bridging
techniques
Building
blocks
systems,
including
sensors,
energy
actuators,
displays,
mechanisms
performances.
Lastly,
we
summarize
potential
applications
conclude
remaining
challenges
prospects.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(8)
Published: Jan. 17, 2022
The
ability
to
form
arbitrary
3D
structures
provides
the
next
level
of
complexity
and
a
greater
degree
freedom
in
design
electronic
devices.
Since
recent
progress
electronics
has
expanded
their
applicability
various
fields
which
structural
conformability
dynamic
configuration
are
required,
high-resolution
printing
technologies
can
offer
significant
potential
for
freeform
electronics.
Here,
novel
methods
is
reviewed,
with
providing
comprehensive
study
on
3D-printable
functional
materials
processes
device
components.
latest
advances
3D-printed
also
reviewed
explain
representative
components,
including
interconnects,
batteries,
antennas,
sensors.
Furthermore,
key
challenges
prospects
next-generation
printed
considered,
future
directions
explored
based
research
that
emerged
recently.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: May 17, 2022
Engineering
wearable
devices
that
can
wirelessly
track
intraocular
pressure
and
offer
feedback-medicine
administrations
are
highly
desirable
for
glaucoma
treatments,
yet
remain
challenging
due
to
issues
of
limited
sizes,
wireless
operations,
cross-coupling.
Here,
we
present
an
integrated
theranostic
contact
lens
in
situ
electrical
sensing
on-demand
anti-glaucoma
drug
delivery.
The
utilizes
a
compact
structural
design,
which
enables
high-degreed
integration
frequency
separation
on
the
curved
surface
lens.
modulus
could
ultra-sensitively
detect
fluctuations,
unique
cantilever
configuration
design
capacitive
circuit.
delivery
employs
efficient
power
transfer
circuit,
trigger
into
aqueous
chamber
via
iontophoresis.
minimally
invasive,
smart,
features
endow
as
promising
system
treatments.
Small,
Journal Year:
2023,
Volume and Issue:
19(27)
Published: April 3, 2023
Abstract
Human
beings
have
a
greater
need
to
pursue
life
and
manage
personal
or
family
health
in
the
context
of
rapid
growth
artificial
intelligence,
big
data,
Internet
Things,
5G/6G
technologies.
The
application
micro
biosensing
devices
is
crucial
connecting
technology
personalized
medicine.
Here,
progress
current
status
from
biocompatible
inorganic
materials
organic
composites
are
reviewed
material‐to‐device
processing
described.
Next,
operating
principles
pressure,
chemical,
optical,
temperature
sensors
dissected
these
flexible
biosensors
wearable/implantable
discussed.
Different
systems
acting
vivo
vitro,
including
signal
communication
energy
supply
then
illustrated.
potential
in‐sensor
computing
for
applications
sensing
also
Finally,
some
essential
needs
commercial
translation
highlighted
future
opportunities
considered.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Nov. 10, 2022
Abstract
Glaucoma
is
one
of
the
irreversible
ocular
diseases
that
can
cause
vision
loss
in
some
serious
cases.
Although
Triggerfish
has
been
commercialized
for
monitoring
intraocular
pressure
glaucoma,
there
no
smart
contact
lens
to
monitor
and
take
appropriate
drug
treatment
response
levels.
Here,
we
report
a
precisely
integrated
theranostic
with
sensitive
gold
hollow
nanowire
based
sensor,
flexible
delivery
system,
wireless
power
communication
systems
an
application
specific
circuit
chip
both
control
glaucoma.
The
sensor
shows
high
strain
sensitivity,
chemical
stability
biocompatibility.
Furthermore,
system
be
used
on-demand
timolol
control.
Taken
together,
levels
successfully
monitored
controlled
by
glaucoma
induced
rabbits.
This
would
harnessed
as
futuristic
personal
healthcare
platform
other
diseases.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(24)
Published: Feb. 7, 2022
Abstract
The
eye
is
one
of
the
most
complex
organs
in
human
body,
containing
rich
and
critical
physiological
information
(e.g.,
intraocular
pressure,
corneal
temperature,
pH)
as
well
a
library
metabolite
biomarkers
glucose,
proteins,
specific
ions).
Smart
contact
lenses
(SCLs)
can
serve
wearable
intelligent
ocular
prosthetic
device
capable
noninvasive
continuous
monitoring
various
essential
physical/biochemical
parameters
drug
loading/delivery
for
treatment
diseases.
Advances
SCL
technologies
growing
public
interest
personalized
health
are
accelerating
research
more
than
ever
before.
Here,
current
status
potential
development
through
comprehensive
review
from
fabrication
to
applications
commercialization
discussed.
First,
material,
fabrication,
platform
designs
SCLs
diagnostic
therapeutic
Then,
latest
advances
clinical
translation
reviewed.
Later,
established
techniques
power
transfer
wireless
data
transmission
applied
devices
summarized.
An
outlook,
future
opportunities,
challenges
developing
next‐generation
also
provided.
With
rise
development,
this
new
paradigm
devices.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Sept. 20, 2022
Abstract
Continuous
monitoring
of
intraocular
pressure,
particularly
during
sleep,
remains
a
grand
challenge
in
glaucoma
care.
Here
we
introduce
class
smart
soft
contact
lenses,
enabling
the
continuous
24-hour
even
sleep.
Uniquely,
lenses
are
built
upon
various
commercial
brands
without
altering
their
intrinsic
properties
such
as
lens
power,
biocompatibility,
softness,
transparency,
wettability,
oxygen
transmissibility,
and
overnight
wearability.
We
show
that
can
seamlessly
fit
across
different
corneal
curvatures
thicknesses
human
eyes
therefore
accurately
measure
absolute
pressure
under
ambulatory
conditions.
perform
comprehensive
set
vivo
evaluations
rabbit,
dog,
from
normal
to
hypertension
confirm
superior
measurement
accuracy,
within-subject
repeatability,
user
comfort
beyond
current
wearable
ocular
tonometers.
envision
will
be
effective
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(19), P. 11488 - 11558
Published: Sept. 25, 2023
The
eye
contains
a
complex
network
of
physiological
information
and
biomarkers
for
monitoring
disease
managing
health,
ocular
devices
can
be
used
to
effectively
perform
point-of-care
diagnosis
management.
This
comprehensive
review
describes
the
target
various
diseases,
including
ophthalmic
metabolic
neurological
based
on
anatomical
background
eye.
also
includes
recent
technologies
utilized
in
eye-wearable
medical
latest
trends
wearable
devices,
specifically
smart
contact
lenses
purpose
After
introducing
other
such
as
retinal
prosthesis,
we
further
discuss
current
challenges
potential
possibilities
lenses.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(20), P. 24923 - 24932
Published: May 9, 2023
Inspired
by
the
interlocked
biological
geometry
of
human
skin,
herein,
we
design
a
flexible
and
transparent
sensor
with
square
column
arrays
composites
Ag
nanoparticles
(AgNPs),
citric
acid
(CA),
poly(vinyl
alcohol)
(PVA),
which
exhibit
multisensory
capabilities
for
pressure,
temperature,
humidity.
As
pressure
sensor,
AgNPs/CA/PVA
possesses
high
sensitivity
(-1.82
kPa-1),
low
detection
limit
(10
Pa),
fast
response
(75
ms),
outstanding
stability
due
to
contact
resistance
pressure.
Because
rigid
dependence
composite
on
can
also
act
as
temperature
exhibits
resolution
(0.1
°C)
reliability
in
detecting
ambient
temperature.
In
addition,
it
is
found
that
amount
water
molecules
adsorbed
PVA
CA
changes
Therefore,
able
detect
humidity
real
time.
This
work
proposes
simple
but
useful
route
fabricate
electrical
skin
has
great
potential
perception
