Implantable Soft Neural Electrodes of Liquid Metals for Deep Brain Stimulation

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 16, 2025

Stimulating large volumes of neural networks using macroelectrodes can modulate disorder-associated brain circuits effectively. However, conventional solid-metal electrodes often cause unwanted damage due to their high mechanical stiffness. In contrast, low-modulus liquid metals provide tissue-like stiffness while maintaining macroscale electrode dimensions. Here, we present implantable soft made from biocompatible for stimulation. These probes be easily fabricated by simply filling polymeric tubes with a metal, offering straightforward method creating stimulation devices. They customized in various lengths and diameters also serve as recording microelectrodes. The tips are enhanced platinum nanoclusters, resulting low impedance effective charge injection preventing metal leakage into tissue. vivo experiments neuropathic pain rat models demonstrate the stability effectiveness these simultaneous recording, demonstrating potential alleviation behavioral control.

Language: Английский

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Smart Contact Lens with Dual‐Sensing Platform for Monitoring Intraocular Pressure and Matrix Metalloproteinase‐9

Advanced Science, Journal Year: 2022, Volume and Issue: 9(12)

Published: Feb. 23, 2022

Contact lenses have become a popular health-monitoring wearable device due to their direct contact with the eyes. By integrating biosensors into lenses, real-time and noninvasive diagnoses of various diseases can be realized. However, current lens sensors often require complex electronics, which may obstruct user's vision or even damage cornea. Moreover, most reported only detect one analyte. Therefore, an optical-based dual-functional smart sensor has been introduced monitor intraocular pressure (IOP) matrix metalloproteinase-9 (MMP-9), both are key biomarkers in many eye-related such as glaucoma. Specifically, elevated IOP is continuously monitored by applying antiopal structure through color changes, without any electronics. Together peptide modified gold nanobowls (AuNBs) surface-enhanced Raman scattering (SERS) substrate, quantitative analysis MMP-9 at low nanomolar range achieved real tear samples. The dual-sensing functions thus demonstrated, providing convenient, noninvasive, potentially multifunctional sensing platform for monitoring health diagnostic human tears.

Language: Английский

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Wireless Non‐Invasive Monitoring of Cholesterol Using a Smart Contact Lens

Advanced Science, Journal Year: 2022, Volume and Issue: 9(28)

Published: Aug. 17, 2022

Abstract Herein, a wireless and soft smart contact lens that enables real‐time quantitative recording of cholesterol in tear fluids for the monitoring patients with hyperlipidemia using smartphone is reported. This incorporates an electrochemical biosensor continuous detection concentrations, stretchable antenna, integrated circuits communication, which makes only device required to operate this remotely without obstructing wearer's vision. The rabbit model utilized confirm correlation between levels fluid blood feasibility diagnostic application cholesterol‐related diseases. Further vivo tests human subjects demonstrated its good biocompatibility, wearability, reliability as non‐invasive healthcare device.

Language: Английский

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Translational gaps and opportunities for medical wearables in digital health

Science Translational Medicine, Journal Year: 2022, Volume and Issue: 14(666)

Published: Oct. 12, 2022

A confluence of advances in biosensor technologies, enhancements health care delivery mechanisms, and improvements machine learning, together with an increased awareness remote patient monitoring, has accelerated the impact digital across nearly every medical discipline. Medical grade wearables—noninvasive, on-body sensors operating clinical accuracy—will play increasingly central role medicine by providing continuous, cost-effective measurement interpretation physiological data relevant to status disease trajectory, both inside outside established settings. Here, we review current technologies highlight critical gaps translation adoption.

Language: Английский

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Mechanically Active Materials and Devices for Bio‐Interfaced Pressure Sensors—A Review

Advanced Materials, Journal Year: 2022, Volume and Issue: 36(43)

Published: Aug. 11, 2022

Abstract Pressures generated by external forces or internal body processes represent parameters of critical importance in diagnosing physiological health and anticipating injuries. Examples span intracranial hypertension from traumatic brain injuries, high blood pressure poor diet, pressure‐induced skin ulcers immobility, edema congestive heart failure. measured on the soft surfaces vital organs within cavities can provide essential insights into patient status progression. Challenges lie development high‐performance sensors that softly interface with biological tissues to enable safe monitoring for extended periods time. This review focuses recent advances mechanically active materials structural designs classes have proven uses these contexts. The discussions include applications such as implantable wearable systems, various unique capabilities wireless continuous monitoring, minimally invasive deployment, natural degradation biofluids, and/or multiplexed spatiotemporal mapping. A concluding section summarizes challenges future opportunities this growing field biomedical research.

Language: Английский

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