X‐ray controlled release strategy in cancer therapy

BMEMat, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Abstract Construction of drug carriers or prodrugs is a common approach to improve the pharmacokinetics molecular drugs and enhance tumor curative effect. Nanocarriers that can be activated by microenvironment including enzymes, pH, redox status, external stimuli such as ultraviolet, ultrasound, magnetism, are booming. As commonly used clinical theranostic with excellent spatiotemporal controllability deep tissue penetration, X‐ray has attracted much attention an stimulus in recent years. The rapid development nanomaterials radiosensitizers radioluminescents further accelerates construction X‐ray‐responsive nanocarriers. In this review, currently developed release systems cancer therapy summarized focus on controlled design.

Language: Английский

---

Enhancing Proton Therapy Efficacy Through Nanoparticle-Mediated Radiosensitization

Cells, Journal Year: 2024, Volume and Issue: 13(22), P. 1841 - 1841

Published: Nov. 7, 2024

Proton therapy, characterized by its unique Bragg peak, offers the potential to optimize destruction of cancer cells while sparing healthy tissues, positioning it as one most advanced treatment modalities currently available. However, in comparison heavy ions, protons exhibit a relatively lower relative biological effectiveness (RBE), which limits efficacy proton therapy. The incorporation nanoparticles for radiosensitization presents novel approach enhance RBE protons. This review provides comprehensive discussion recent advancements augmenting effects therapy through use nanoparticles. It examines various types that have been focus extensive research, elucidates their mechanisms radiation sensitization, and evaluates factors influencing efficiency this sensitization process. Furthermore, discusses latest synergistic therapeutic strategies integrate nanoparticle-mediated outlines prospective directions future application conjunction with

Language: Английский

---

Long-Term and Real-Time Post-External Radiotherapy Assessment Based on an In Situ Activatable Radiolabeled Platform

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Long-term monitoring in postoperative assessment is essential for clinicians to assess the effectiveness of therapies and establish subsequent clinical pharmacotherapeutic plans. However, precise real-time often overlooked, relying instead on various histopathological cytological assays or experience physicians. Therefore, it urgent develop a general strategy long-term, real-time, accurate assessment. Herein, we present facile method utilizing radiolabeled probes postradiotherapy The probe consists tumor-specific targeting group, an external radiotherapy-activated peptide sequence (DEVD), 177Lu-1,4,7,10-tetraazacyclododecane-N,N′,N″,N‴-tetraacetic acid (DOTA)-decorated tetraphenyl ethylene. This design not only avoids photobleaching limitations associated with traditional organic ligands long-term but also achieves situ aggregation at lesion site, allowing prolonged tumor retention over 96 h. work serves as glance assessment, broadening possibilities design, application, translation radionuclide-labeled probes.

Language: Английский

---

Biotin Receptor-Targeting Pt^IV Oxygen Carrying Prodrug Amphiphile for Alleviating Tumor Hypoxia Induced Immune Chemotherapy Suppression

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Platinum (Pt)-based chemotherapeutic agents, known for their potent cytotoxicity, are extensively used in clinical oncology. However, therapeutic efficacy is severely limited by a variety of factors, particularly the hypoxic tumor microenvironment (TME), which not only impedes effective drug delivery but also triggers immune suppression, further diminishing antitumor effects Pt drugs. In response to these challenges, we have developed biotin receptor (BR)-targeting oxaliplatin (OXA)-based PtIV prodrug, named Lipo-OPtIV-BT, could encapsulate hemoglobin (Hb) as an oxygen carrier, forming PtIV-loaded lipid nanoparticles (Hb@BTOPtIV). The design Hb@BTOPtIV aims address dual issues poor and suppression effectively increasing local tension TME. Notably, our findings demonstrate that cytotoxic BR-targeting prodrug increased levels synergistically reverse microenvironment, leading improved efficacy. We observed significantly biodistribution drug, enabling it preferentially accumulate regions. Importantly, enhanced oxygenation within TME plays critical role reshaping landscape tumor, promoting more favorable environment chemotherapy. This reversal evidenced infiltration T cells reduced regulatory (Tregs) tumor. These highlight promising potential using amphiphiles improve accumulation at sites counteract immunosuppression induced hypoxia.

Language: Английский

---

Perspective to clinical translation of radiotherapy-activated prodrugs: challenges and advances

Medicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100076 - 100076

Published: March 1, 2025

Language: Английский

---

Tunable Hydro/Dicarboxylation of Ethylene with CO₂ via a Barrierless Radiolytic Free-Radicals Pathway

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

The hydro/dicarboxylation of ethylene (C2H4) feedstock with CO2 to produce high-value carboxylic acids is an industrially relevant yet challenging reaction due their extremely low reactivities. Herein, we present effective strategy synthesize propionic acid and succinic from a mixture C2H4 catalyzed by high-energy water radiolysis. process involves the generation radical anions via barrierless attachment hydrated electrons CO2, facilitating ambient, continuous carboxylation efficiency 81.4%. Utilizing easily available electron beam irradiation, achieved combined production rate 0.34 mmol L–1 min–1 for acids, which unattainable existing methods. Notably, product selectivity between hydro- dicarboxylation was dose-rate/beam intensity-dependent: high-dose-rate irradiation favored formation proportional yield up 65.4%, while milder conditions resulted in 85.1% acid. We suggested that simplicity approach promote circular carbon sustainable chemical industry.

Language: Английский

---

Alkyl Chloride-Functionalized Polymers Mediate Oxidation of Thioethers Initiated by Ionizing Radiation

ACS Applied Polymer Materials, Journal Year: 2025, Volume and Issue: 7(6), P. 3835 - 3841

Published: March 19, 2025

Irradiation of aqueous solutions containing alkyl chlorides generates peroxyl radicals by reactions chlorides, electrons, and dissolved oxygen. The radical can oxidize thioethers to sulfoxides, a transformation that has relevance for targeted or triggered drug delivery. However, small-molecule induce liver damage, which limits their potential application in anticancer therapy. Here, we show bound hydrophilic random copolymer chain behave similar chlorides. Our work shows using polymeric be an alternative provided the chloride functionalities are easily accessible electrons.

Language: Английский

---

Coupling nitric oxide photo-uncaging with radiotherapy

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216630 - 216630

Published: March 30, 2025

Language: Английский

---

Porphyrin-Engineered ¹²⁵I-Nanoseeds as a Prototype for Immunogenic Brachytherapy

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Internal radiotherapy holds a greater potential than external for precisely destroying tumors and minimizing side effects. 125I seeds are routinely used as radioactive sources in clinical brachytherapy patients with various types of cancers. However, losing ground to flashier cancer therapies, mainly due their limited therapeutic efficacy, uneven dose distribution, negligible antitumor immune response. Here, we present porphyrin-engineered 125I-nanoseeds prototype immunogenic brachytherapy. were rationally designed core-shell structure, which Au@Ag cores enhance the energy deposition photons produce more ·OH, while porphyrin shells transfer Auger electrons generate 1O2. Benefiting from improving utilization efficiency, can efficiently ·OH 1O2 tumors, enhancing efficacy inducing cell death both murine tumor models human tissues. When combined checkpoint blockade immunotherapy, elicit systemic response tumor-bearing mice, inhibiting distant metastatic tumors. This work demonstrates that synergize dynamic therapy, resulting enhanced compared those seeds, is expected improve applied prospect

Language: Английский

---

Targeted Radionuclide Therapy Activates Prodrugs for Treating Metastasis

ACS Central Science, Journal Year: 2024, Volume and Issue: 10(12), P. 2321 - 2330

Published: Dec. 5, 2024

Over 90% of cancer patients succumb to metastasis, yet conventional frontline therapy struggles halt the progression metastatic tumors. Targeted radionuclide therapy, which delivers radiation precisely tumor sites, shows promise for treating metastasis. The rational design a prodrug activation platform using radionuclides would be an ideal approach synergize chemotherapy with targeted it has not been established. Here, we present therapy-induced cleavage chemistry that enables controlled release oxaliplatin and its axis ligands from oxaliplatin(IV) complexes in living systems. Of note, this strategy demonstrates feasibility over clinically relevant β-emitting exhibits dose dependence. These advantages were taken into account, Lutetium-177-activatable platinum(IV) based system was designed could achieve localized at site high efficiency, thereby suppressing subcutaneous 4T1 In summary, our highlights potential as reaction switches, bridging gap between radiotherapy-induced internal radiation. It may provide new perspective future combination therapy.

Language: Английский

---