Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

Molecular Cell, Journal Year: 2019, Volume and Issue: 74(4), P. 640 - 650

Published: May 1, 2019

Language: Английский

---

Functions of N6-methyladenosine and its role in cancer

Molecular Cancer, Journal Year: 2019, Volume and Issue: 18(1)

Published: Dec. 1, 2019

N6-methyladenosine (m6A) is methylation that occurs in the N6-position of adenosine, which most prevalent internal modification on eukaryotic mRNA. Accumulating evidence suggests m6A modulates gene expression, thereby regulating cellular processes ranging from cell self-renewal, differentiation, invasion and apoptosis. M6A installed by methyltransferases, removed demethylases recognized reader proteins, regulate RNA metabolism including translation, splicing, export, degradation microRNA processing. Alteration levels participates cancer pathogenesis development via expression tumor-related genes like BRD4, MYC, SOCS2 EGFR. In this review, we elaborate recent advances research enzymes. We also highlight underlying mechanism progression. Finally, review corresponding potential targets therapy.

Language: Английский

---

RNA modifications modulate gene expression during development

Science, Journal Year: 2018, Volume and Issue: 361(6409), P. 1346 - 1349

Published: Sept. 28, 2018

RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programs. They affect diverse eukaryotic biological processes, and the correct deposition many these is required for normal development. Messenger (mRNA) regulate various aspects mRNA metabolism. For example,

Language: Английский

---

m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer

Cancer Cell, Journal Year: 2020, Volume and Issue: 37(3), P. 270 - 288

Published: March 1, 2020

Language: Английский

---

Role of RNA modifications in cancer

Nature reviews. Cancer, Journal Year: 2020, Volume and Issue: 20(6), P. 303 - 322

Published: April 16, 2020

Language: Английский

---

The role of m6A RNA methylation in human cancer

Molecular Cancer, Journal Year: 2019, Volume and Issue: 18(1)

Published: May 29, 2019

N6-methyladenosine (m6A) is identified as the most common, abundant and conserved internal transcriptional modification, especially within eukaryotic messenger RNAs (mRNAs). M6A modification installed by m6A methyltransferases (METTL3/14, WTAP, RBM15/15B KIAA1429, termed "writers"), reverted demethylases (FTO ALKBH5, "erasers") recognized binding proteins (YTHDF1/2/3, IGF2BP1 HNRNPA2B1, "readers"). Acumulating evidence shows that, RNA methylation has an outsize effect on production/metabolism participates in pathogenesis of multiple diseases including cancers. Until now, molecular mechanisms underlying various tumors have not been comprehensively clarified. In this review, we mainly summarize recent advances biological function modifications human cancer discuss potential therapeutic strategies.

Language: Английский

---

RNA in cancer

Nature reviews. Cancer, Journal Year: 2020, Volume and Issue: 21(1), P. 22 - 36

Published: Oct. 20, 2020

Language: Английский

---

Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells

Nature, Journal Year: 2019, Volume and Issue: 566(7743), P. 270 - 274

Published: Feb. 1, 2019

Language: Английский

---

The potential role of RNA N6-methyladenosine in Cancer progression

Molecular Cancer, Journal Year: 2020, Volume and Issue: 19(1)

Published: May 12, 2020

Abstract N6-methyladenosine (m6A) is considered the most common, abundant, and conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA). m6A installed by methyltransferases (METTL3/14, WTAP, RBM15/15B, VIRMA ZC3H13, termed “writers”), removed demethylases (FTO, ALKBH5, ALKBH3, “erasers”), recognized m6A-binding proteins (YTHDC1/2, YTHDF1/2/3, IGF2BP1/2/3, HNRNP, eIF3, “readers”). Accumulating evidence suggests that methylation greatly impacts metabolism involved pathogenesis of many kinds diseases, including cancers. In this review, we focus on physiological functions modification its related regulators, as well potential biological roles these elements human tumors.

Language: Английский

---

The role of m6A RNA methylation in cancer

Biomedicine & Pharmacotherapy, Journal Year: 2019, Volume and Issue: 112, P. 108613 - 108613

Published: Feb. 19, 2019

N6-methyladenosine (m6A), the most abundant internal modification of RNA in eukaryotic cells, has gained increasing attention recent years. The m6A affects multiple aspects metabolism, ranging from processing, nuclear export, translation to decay. Emerging evidence suggests that methylation plays a critical role cancer through various mechanisms. Moreover, provided more possibilities for early diagnosis and treatment cancers. In this review, we focus on m6A-associated mechanisms functions several major malignancies summarize dual as well its prospects cancer.

Language: Английский

---