The global landscape and research trend of phase separation in cancer: a bibliometric analysis and visualization DOI Creative Commons
Mengzhu Li,

Yi-Zhan Zhang,

Jiajun Zhao

et al.

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: June 2, 2023

Cancer as a deathly disease with high prevalence has impelled researchers to investigate its causative mechanisms in the search for effective therapeutics. Recently, concept of phase separation been introduced biological science and extended cancer research, which helps reveal various pathogenic processes that have not identified before. As process soluble biomolecules condensed into solid-like membraneless structures, is associated multiple oncogenic processes. However, there are no bibliometric characteristics these results. To provide future trends identify new frontiers this field, analysis was conducted study.The Web Science Core Collection (WoSCC) used literature on from 1/1/2009 31/12/2022. After screening literature, statistical visualization were carried out by VOSviewer software (version 1.6.18) Citespace (Version 6.1.R6).A total 264 publications, covering 413 organizations 32 countries, published 137 journals, an increasing trend publication citation numbers per year. The USA China two countries largest number University Chinese Academy Sciences most active institution based articles cooperations. Molecular Cell frequent publisher citations H-index. productive authors Fox AH, De Oliveira GAP, Tompa P. Overlay, whilst few had strong collaboration each other. combined concurrent burst keywords revealed research hotspots related tumor microenvironments, immunotherapy, prognosis, p53, cell death.Phase separation-related remained hot streak period exhibited promising outlook. Although inter-agency existed, cooperation among groups rare, author dominated field at current stage. Investigating interfaced effects between microenvironments carcinoma behaviors, constructing relevant prognoses therapeutics such immune infiltration-based prognosis immunotherapy might be next study cancer.

Language: Английский

Transcription regulation by biomolecular condensates DOI
Gaofeng Pei, Heankel Lyons, Pilong Li

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Language: Английский

Citations

11
Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration DOI
Xuezhao Liu, Dazhuan Xin,

Xiaowen Zhong

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(10), P. 2465 - 2484.e22

Published: May 1, 2024

Language: Английский

Citations

10
Emerging regulatory mechanisms and functions of biomolecular condensates: implications for therapeutic targets DOI Creative Commons
Soyoung Jeon, Yong‐Duck Chung, Jae‐Sung Lim

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 6, 2025

Cells orchestrate their processes through complex interactions, precisely organizing biomolecules in space and time. Recent discoveries have highlighted the crucial role of biomolecular condensates-membrane-less assemblies formed condensation proteins, nucleic acids, other molecules-in driving efficient dynamic cellular processes. These condensates are integral to various physiological functions, such as gene expression intracellular signal transduction, enabling rapid finely tuned responses. Their ability regulate signaling pathways is particularly significant, it requires a careful balance between flexibility precision. Disruption this can lead pathological conditions, including neurodegenerative diseases, cancer, viral infections. Consequently, emerged promising therapeutic targets, with potential offer novel approaches disease treatment. In review, we present recent insights into regulatory mechanisms by which influence pathways, roles health disease, strategies for modulating condensate dynamics approach. Understanding these emerging principles may provide valuable directions developing effective treatments targeting aberrant behavior diseases.

Language: Английский

Citations

1
The recent advances and implications in cancer therapy for the hippo pathway DOI
Siew Wee Chan, Choon Nam Ong, Wanjin Hong

et al.

Current Opinion in Cell Biology, Journal Year: 2025, Volume and Issue: 93, P. 102476 - 102476

Published: Feb. 4, 2025

Language: Английский

Citations

1
New Insights into YAP/TAZ-TEAD-Mediated Gene Regulation and Biological Processes in Cancer DOI Open Access
Yang Zhao,

Marisela Sheldon,

Yutong Sun

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(23), P. 5497 - 5497

Published: Nov. 21, 2023

The Hippo pathway is conserved across species. Key mammalian kinases, including MST1/2 and LATS1/2, inhibit cellular growth by inactivating the TEAD coactivators, YAP, TAZ. Extensive research has illuminated roles of signaling in cancer, development, regeneration. Notably, dysregulation components not only contributes to tumor metastasis, but also renders tumors resistant therapies. This review delves into recent on YAP/TAZ-TEAD-mediated gene regulation biological processes cancer. We focus several key areas: newly identified molecular patterns YAP/TAZ activation, emerging mechanisms that contribute metastasis cancer therapy resistance, unexpected suppression, advances therapeutic strategies targeting this pathway. Moreover, we provide an updated view YAP/TAZ's functions, discuss ongoing controversies, offer perspectives specific debated topics rapidly evolving field.

Language: Английский

Citations

18
Biomolecular condensates: hubs of Hippo-YAP/TAZ signaling in cancer DOI

Karrie Mei-Yee Kiang,

Leena Ahad,

Xiaowen Zhong

et al.

Trends in Cell Biology, Journal Year: 2024, Volume and Issue: 34(7), P. 566 - 577

Published: May 27, 2024

Language: Английский

Citations

6
Prion-like domain mediated phase separation of ARID1A promotes oncogenic potential of Ewing’s sarcoma DOI Creative Commons
Yong Ryoul Kim, Jaegeon Joo, Hee Jung Lee

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 3, 2024

Liquid-liquid phase separation (LLPS) facilitates the formation of membraneless organelles within cells, with implications in various biological processes and disease states. AT-rich interactive domain-containing protein 1A (ARID1A) is a chromatin remodeling factor frequently associated cancer mutations, yet its functional mechanism remains largely unknown. Here, we find that ARID1A harbors prion-like domain (PrLD), which liquid condensates through PrLD-mediated LLPS. The nuclear formed by LLPS are significantly elevated Ewing's sarcoma patient specimen. Disruption results diminished proliferative invasive abilities cells. Through genome-wide structure transcription profiling, identify condensate localizes to EWS/FLI1 target enhancers induces long-range architectural changes forming hubs at oncogenic genes. Collectively, our findings demonstrate promotes potential LLPS, offering therapeutic approach for treating sarcoma. mutated cancer. Here authors report plays role liquid-liquid (LLPS). were patients.

Language: Английский

Citations

6
CBX4 deletion promotes tumorigenesis under KrasG12D background by inducing genomic instability DOI Creative Commons
Fangzhen Chen,

Wulei Hou,

Xiangtian Yu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Sept. 12, 2023

Chromobox protein homolog 4 (CBX4) is a component of the Polycomb group (PcG) multiprotein repressive complexes 1 (PRC1), which participated in several processes including growth, senescence, immunity, and tissue repair. CBX4 has been shown to have diverse, even opposite functions different types malignancy previous studies. In this study, we found that deletion promoted lung adenocarcinoma (LUAD) proliferation progression KrasG12D mutated background. vitro, over 50% Cbx4L/L, mouse embryonic fibroblasts (MEFs) underwent apoptosis initial period after Adeno-Cre virus treatment, while small portion survival cells got increased transformation abilities, called selected Cbx4-/-, cells. Karyotype analysis RNA-seq data revealed chromosome instability genome changes compared with Further study showed P15, P16 other apoptosis-related genes were upregulated primary due instability, led large population cell apoptosis. addition, multiple pathways Hippo pathway basal cancer-related signatures altered cells, ultimately leading cancer. We also low expression LUAD was associated poorer prognosis under Kras mutation background from human clinical data. To sum up, causes genomic induce tumorigenesis Our demonstrates plays an emerging role tumorigenesis, great importance guiding treatment adenocarcinoma.

Language: Английский

Citations

13
Phase separation in gene transcription control DOI Creative Commons
Chengyu Li, Zhuo Li,

Zhibing Wu

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2023, Volume and Issue: 55(7), P. 1052 - 1063

Published: May 24, 2023

Phase separation provides a general mechanism for the formation of biomolecular condensates, and it plays vital role in regulating diverse cellular processes, including gene expression. Although transcription factors coactivators has long been understood, how phase is involved this process just beginning to be explored. In review, we highlight recent advance elucidating molecular mechanisms functions transcriptional condensates expression control. We discuss different formed at each stage cycle they are dynamically regulated response extracellular cues that cause rapid changes Furthermore, present new findings regarding dysregulation their implications human diseases.

Language: Английский

Citations

13
Onco-condensates: formation, multi-component organization, and biological functions DOI Creative Commons
Chenxi Xu, Arum Kim,

Joshua M. Corbin

et al.

Trends in cancer, Journal Year: 2023, Volume and Issue: 9(9), P. 738 - 751

Published: June 20, 2023

Language: Английский

Citations

12