Recent developments in the construction and applications of platinum-based metallacycles and metallacagesviacoordination

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(12), P. 3889 - 3919

Published: Jan. 1, 2020

Coordination-driven suprastructures have attracted much interest due to their unique properties. Among these structures, platinum-based architectures been broadly studied facile preparation. The resultant two- or three-dimensional (2D 3D) systems many advantages over precursors, such as improved emission tuning, sensitivity sensors, and capture release of guests, they applied in biomedical diagnosis well catalysis. Herein, we review the recent results related coordination-driven self-assembly (CDSA), text is organized emphasizes both synthesis new metallacycles metallacages various applications.

Language: Английский

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freud: A software suite for high throughput analysis of particle simulation data

Computer Physics Communications, Journal Year: 2020, Volume and Issue: 254, P. 107275 - 107275

Published: March 17, 2020

Language: Английский

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Protein Assembly by Design

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(22), P. 13701 - 13796

Published: Aug. 18, 2021

Proteins are nature's primary building blocks for the construction of sophisticated molecular machines and dynamic materials, ranging from protein complexes such as photosystem II nitrogenase that drive biogeochemical cycles to cytoskeletal assemblies muscle fibers motion. Such natural systems have inspired extensive efforts in rational design artificial last two decades. As blocks, proteins highly complex, terms both their three-dimensional structures chemical compositions. To enable control over self-assembly complex molecules, scientists devised many creative strategies by combining tools principles experimental computational biophysics, supramolecular chemistry, inorganic materials science, polymer among others. Owing these innovative strategies, what started a purely structure-building exercise decades ago has, short order, led with unprecedented functions protein-based unusual properties. Our goal this review is give an overview exciting interdisciplinary area research, first outlining been controlling self-assembly, then describing diverse assemblies, finally highlighting emergent properties assemblies.

Language: Английский

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Protein Assemblies: Nature-Inspired and Designed Nanostructures

Biomacromolecules, Journal Year: 2019, Volume and Issue: 20(5), P. 1829 - 1848

Published: March 26, 2019

Ordered protein assemblies are attracting interest as next-generation biomaterials with a remarkable range of structural and functional properties, leading to potential applications in biocatalysis, materials templating, drug delivery vaccine development. This Review covers ordered including nanowires/nanofibrils, nanorings, nanotubes, designed two- three-dimensional lattices protein-like cages polyhedral virus-like cage structures. The main focus is on assemblies, which the spatial organization proteins controlled by tailored noncovalent interactions (including metal ion binding interactions, electrostatic ligand–receptor among others) or careful design modified (mutant) de novo constructs. modification natural bacterial S-layers cage-like rod-like viruses impart novel function, e.g. enzymatic activity, also considered. A diversity structures have been created using distinct approaches, this provides summary state-of-the-art development these systems, exceptional advanced bionanomaterials for applications.

Language: Английский

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Programmed spatial organization of biomacromolecules into discrete, coacervate-based protocells

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: Dec. 8, 2020

The cell cytosol is crowded with high concentrations of many different biomacromolecules, which difficult to mimic in bottom-up synthetic research and limits the functionality existing protocellular platforms. There thus a clear need for general, biocompatible, accessible tool more accurately emulate this environment. Herein, we describe development discrete, membrane-bound coacervate-based platform that utilizes well-known binding motif between Ni

Language: Английский

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Photo‐Regulated Supramolecular Polymers: Shining Beyond Disassembly and Reassembly

Advanced Optical Materials, Journal Year: 2019, Volume and Issue: 7(16)

Published: March 3, 2019

Abstract Stimuli‐responsive materials, especially those that can respond to light stimuli, are highly attractive and promising for scientists working in many fields. Recently, the emerging supramolecular polymers materials found be versatile reliable construction of smart soft owing their dynamic nature. Aiming regulate properties by remote external previous efforts have focused on photo‐controlled assembly/disassembly polymers, showing several expectable applications light‐responsive materials. In this progress report, recently summarized which exhibit conceptually new functions beyond reversible disassembly/reassembly, such as light‐regulated morphology transformation, tunable fluorescent emission, switchable self‐healing ability, muscle‐like actuation, programmed shape memory. Remaining questions challenges design construct these optical discussed detail based molecular engineering strategy. Additionally, unsolved given discuss possible opportunities field.

Language: Английский

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Supercharged Proteins and Polypeptides

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(20)

Published: Jan. 15, 2020

Abstract Electrostatic interactions play a vital role in nature. Biomacromolecules such as proteins are orchestrated by electrostatics, among other intermolecular forces, to assemble and organize biochemistry. Natural with high net charge exist folded state or unstructured can be an inspiration for scientists artificially supercharge protein entities. Recent findings show that supercharging allows control of their properties temperature resistance catalytic activity. One elegant method transfer the favorable supercharged is fabrication fusions. Genetically engineered, polypeptides (SUPs) just one promising fusion tool. SUPs also complexed artificial entities yield thermotropic lyotropic liquid crystals liquids. These architectures represent novel bulk materials sensitive external stimuli. Interestingly, undergo fluid–fluid phase separation form coacervates. coacervates even directly generated living cells combined dissipative fiber assemblies induce life‐like features. Supercharged developed into exciting classes materials. Their synthesis, structures, summarized. Moreover, potential applications highlighted challenges discussed.

Language: Английский

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Hierarchical Self‐assembly of Discrete Metal–Organic Cages into Supramolecular Nanoparticles for Intracellular Protein Delivery

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(10), P. 5429 - 5435

Published: Nov. 28, 2020

Hierarchical self-assembly (HAS) is a powerful approach to create supramolecular nanostructures for biomedical applications. This potency, however, generally challenged by the difficulty of controlling HAS biomacromolecules and functionality resulted nanostructures. Herein, we report modular discrete metal-organic cages (MOC) into nanoparticles, its potential intracellular protein delivery cell-fate specification. The hierarchical coordination-driven adamantane-functionalized M

Language: Английский

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Colloidal fibers and rings by cooperative assembly

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: Sept. 2, 2019

Abstract Janus colloids with one attractive patch on an otherwise repulsive particle surface serve as model systems to explore structure formation of particles chemically heterogeneous surfaces such proteins. While there are numerous computer studies, few experimental realizations due a lack means produce well-controlled variable balance. Here, we report simple scalable method precisely vary the balance over wide range and selectively functionalize DNA. We observe, via experiment simulation, dynamic diverse superstructures: colloidal micelles, chains, or bilayers, depending Flexible dimer chains form through cooperative polymerization while trimer by two-stage process, first into disordered aggregates followed condensation more ordered stiff chains. Introducing substrate binding depletion catalyzes nonequilibrium rings that do not form.

Language: Английский

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Hierarchical Materials from High Information Content Macromolecular Building Blocks: Construction, Dynamic Interventions, and Prediction

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(24), P. 17397 - 17478

Published: Oct. 19, 2022

Hierarchical materials that exhibit order over multiple length scales are ubiquitous in nature. Because hierarchy gives rise to unique properties and functions, many have sought inspiration from nature when designing fabricating hierarchical matter. More more, however, nature's own high-information content building blocks, proteins, peptides, peptidomimetics, being coopted build because the information determines structure, function, interfacial interactions can be readily encoded these versatile macromolecules. Here, we take stock of recent progress rational design characterization produced blocks with a focus on stimuli-responsive "smart" architectures. We also review advances use computational simulations data-driven predictions shed light how side chain chemistry conformational flexibility macromolecular drive emergence acquisition ionic, solvent, surface effects influence outcomes assembly. Continued above areas will ultimately usher an era where understanding designed interactions, effects, solution conditions harnessed achieve predictive synthesis across scale emergent phenomena self-assembly reconfiguration blocks.

Language: Английский

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