Nachrichten aus der Chemie,
Journal Year:
2024,
Volume and Issue:
72(10), P. 52 - 59
Published: Sept. 30, 2024
Abstract
Responsive
Polymere
ändern
ihre
Materialeigenschaften
und
reagieren
über
programmierte
molekulare
Prozesse
auf
Umwelteinflüsse.
Solche
Materialdesigns
standen
dieses
Jahr
im
Fokus
vieler
Anwendungen:
Sie
verbessern
die
Rezyklierbarkeit,
führen
zu
selbstreguliertem
Abbau
Selbstheilung,
transportieren
Wirkstoffe
setzen
sie
frei
oder
ahmen
biologische
Systeme
mit
komplexen
Signalverarbeitungsabläufen
adaptiven
Strukturen
nach.
Für
eine
nachhaltige
Kunststoffwirtschaft
bleiben
zudem
leitfähige
biobasierte
Monomere
wichtig.
JACS Au,
Journal Year:
2024,
Volume and Issue:
4(1), P. 20 - 39
Published: Jan. 3, 2024
Glycans
in
the
form
of
oligosaccharides,
polysaccharides,
and
glycoconjugates
are
ubiquitous
nature,
their
structures
range
from
linear
assemblies
to
highly
branched
decorated
constructs.
Solution
state
NMR
spectroscopy
facilitates
elucidation
preferred
conformations
shapes
saccharides,
motions,
dynamic
aspects
related
processes
over
time
as
well
study
transient
interactions
with
proteins.
Identification
intermolecular
networks
at
atomic
level
detail
recognition
events
by
carbohydrate-binding
proteins
known
lectins,
unraveling
antibodies,
revealing
substrate
scope
action
glycosyl
transferases
employed
for
synthesis
oligo-
polysaccharides
may
efficiently
be
analyzed
spectroscopy.
By
utilizing
active
nuclei
present
glycans
derivatives
thereof,
including
isotopically
enriched
compounds,
detailed
information
can
obtained
experiments.
Subsequent
analysis
aided
quantum
chemical
calculations
parameters,
machine
learning-based
methodologies
artificial
intelligence.
Interpretation
results
experiments
complemented
extensive
molecular
dynamics
simulations
obtain
three-dimensional
models,
thereby
clarifying
involving
glycans.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(9), P. 6369 - 6376
Published: Feb. 20, 2024
Systematic
structural
studies
of
model
oligopeptides
revealed
important
aspects
protein
folding
and
offered
design
principles
to
access
non-natural
materials.
In
the
same
way,
rules
that
regulate
glycan
could
be
established
by
studying
synthetic
oligosaccharide
models.
However,
their
analysis
is
often
limited
due
analytical
complexity.
By
utilizing
a
capable
spontaneously
into
hairpin
conformation
as
system,
we
investigated
factors
contribute
its
conformational
stability
in
aqueous
solution.
The
modular
featured
trisaccharide
turn
unit
two
β-1,4-oligoglucoside
stacking
strands
allowed
for
systematic
chemical
modifications
sequence,
including
introduction
NMR
labels
staples.
Nuclear
magnetic
resonance
assisted
molecular
dynamics
simulations
stereoelectronic
effects
multiple
glycan–glycan
interactions
are
major
determinants
stabilization.
Chemical
primary
sequence
(e.g.,
strand
elongation)
can
employed
fine-tune
rigidity
motifs
distant
from
modification
sites.
These
results
inspire
other
architectures,
with
implications
glycobiology
material
sciences.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(14), P. 9801 - 9810
Published: March 29, 2024
The
sequence-controlled
assembly
of
nucleic
acids
and
amino
into
well-defined
superstructures
constitutes
one
the
most
revolutionary
technologies
in
modern
science.
elaboration
such
from
carbohydrates,
however,
remains
elusive
largely
unexplored
on
account
their
intrinsic
constitutional
configurational
complexity,
not
to
mention
inherent
conformational
flexibility.
Here,
we
report
bottom-up
two
classes
hierarchical
that
are
formed
a
highly
flexible
cyclo-oligosaccharide─namely,
cyclofructan-6
(CF-6).
formation
coordinative
bonds
between
oxygen
atoms
CF-6
alkali
metal
cations
(i)
locks
myriad
conformations
few
rigid
conformations,
(ii)
bridges
adjacent
ligands,
(iii)
gives
rise
multiple-level
three
extended
frameworks.
present
these
frameworks
have
been
shown
modulate
nanomechanical
properties.
This
research
highlights
unique
opportunities
constructing
convoluted
carbohydrates
should
encourage
future
endeavors
this
underinvestigated
field
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: April 20, 2024
Abstract
The
synthesis
of
sequence-regulated
oligosulfates
has
not
yet
been
established
due
to
the
difficulties
in
precise
reactivity
control.
In
this
work,
we
report
an
example
a
multi-directional
divergent
iterative
method
furnish
based
on
chain
homologation
approach,
which
fluorosulfate
unit
is
regenerated.
oligosulfate
sequences
are
determined
by
high
resolution
mass
spectrometry
hydrolyzed
fragments,
and
polysulfate
periodic
copolymers
synthesized
using
oligomeric
bisfluorosulfates
bi-directional
fashion.
synthetic
utility
ligation
demonstrated
preparing
crosslinked
network
polymers
as
adhesive
materials.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(42)
Published: July 27, 2024
Abstract
In
this
research
article,
we
report
on
the
strengthening
of
a
non‐classical
hydrogen
bond
(C−H⋅⋅⋅O)
by
introducing
electron
withdrawing
groups
at
carbon
atom.
The
approach
is
demonstrated
example
derivatives
physiological
E‐selectin
ligand
sialyl
Lewis
x
(
1
,
sLe
).
Its
affinity
mainly
due
to
beneficial
entropy
term,
which
predominantly
caused
pre‐organization
in
its
binding
conformation.
We
have
shown,
that
among
elements
responsible
for
pre‐organization,
stabilization
between
H−C5
l
‐fucose
and
ring
oxygen
O5
neighboring
d
‐galactose
moiety
essential
yields
7.4
kJ
mol
−1
.
This
effect
could
be
further
strengthened
replacing
6,6,6‐trifluoro‐
leading
an
improved
H‐bond
14.9
i.e.,
bioactive
For
series
glycomimetics
),
outcome
confirmed
high
field
NMR‐shifts
Fuc
X‐ray
diffraction
analysis
co‐crystallized
with
as
well
isothermal
titration
calorimetry.
Furthermore,
electron‐withdrawing
character
CF
3
‐group
beneficially
influences
pharmacokinetic
properties
mimetics.
Thus,
acid‐stability,
prerequisite
gastrointestinal
stability,
substantially
improved.
FEBS Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 18, 2025
α2
→
8
polysialic
acid
(polySia),
the
capsular
polysaccharide
on
Neisseria
meningitidis
serogroup
B
and
Escherichia
coli
K1,
elicits
poor
immunogenic
properties.
A
solution
structure
might
clarify
cause.
From
X‐ray
neutron
small‐angle
scattering,
we
find
that
supramolecular
of
polySia
exhibits
parallel‐chain
binding.
Also,
striking
structural
changes
occur
upon
addition
calcium
to
these
solutions
but
still
with
parallel
motif.
The
major
histocompatibility
complex
requires
entities
in
molecular
weight
range
600–3000
Da,
structures
determined
here
argue
endosomes
oligomers
correct
size
be
immunologically
effective
are
instead
bound
up
as
chains.
This
is
expected
reduce
possible
concentrations
so
capability
acid.
