Brain circuits for pain and its treatment

Science Translational Medicine, Journal Year: 2021, Volume and Issue: 13(619)

Published: Nov. 10, 2021

Understanding the organization of brain’s pain circuits is critical for developing effective treatments patients suffering from chronic pain.

Language: Английский

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The Potential of Functional Near-Infrared Spectroscopy-Based Neurofeedback—A Systematic Review and Recommendations for Best Practice

Frontiers in Neuroscience, Journal Year: 2020, Volume and Issue: 14

Published: July 21, 2020

Background: The effects of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI)-neurofeedback on brain activation behaviors have been studied extensively in the past. More recently, researchers begun to investigate near-infrared spectroscopy-based neurofeedback (fNIRS-neurofeedback). FNIRS is a neuroimaging technique based hemodynamics, which easy use, portable, inexpensive, has reduced sensitivity movement artifacts. Method: We provide first systematic review database fNIRS-neurofeedback studies, synthesizing findings from 22 peer-reviewed studies (including total N = 441 participants; 337 healthy, 104 patients). (1) give comprehensive overview how training protocols were implemented, (2) online signal-processing methods used, (3) evaluate quality using pre-set methodological reporting criteria also present statistical sensitivity/power analyses, (4) effectiveness modulating activation, (5) its changing behavior healthy pathological populations. Results discussion: (1-2) Published are heterogeneous (e.g., targets, investigated populations, applied protocols, methods). Large randomized controlled trials still lacking. In view novelty field, published moderate. identified room for improvement important information power detect realistic effects. Several show that people can regulate hemodynamic signals cortical regions with these indicate feasibility motor control prefrontal functioning participants ameliorating symptoms clinical populations (stroke, ADHD, autism, social anxiety). However, valid conclusions about specificity or potential utility premature. Conclusion: Due advantages practicability relatively low cost, might suitable powerful alternative EEG fMRI great translation neurofeedback. Together more rigorous research practices, further improvements may lead solid understanding fNIRS-neurofeedback. Future will benefit exploiting fNIRS, offers unique opportunities research.

Language: Английский

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Neurofeedback training in major depressive disorder: A systematic review of clinical efficacy, study quality and reporting practices

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 125, P. 33 - 56

Published: Feb. 15, 2021

Language: Английский

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Neurofeedback through the lens of reinforcement learning

Trends in Neurosciences, Journal Year: 2022, Volume and Issue: 45(8), P. 579 - 593

Published: May 10, 2022

Language: Английский

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Review of EEG-based neurofeedback as a therapeutic intervention to treat depression

Psychiatry Research Neuroimaging, Journal Year: 2023, Volume and Issue: 329, P. 111591 - 111591

Published: Jan. 13, 2023

Depression, or major depressive disorder, is a common mental disorder that affects individuals' behavior, mood, and physical health, its prevalence has increased during the lockdowns implemented to curb COVID-19 pandemic. There an urgent need update treatment recommendations for disorders such crises. Conventional interventions treat depression include long-term pharmacotherapy cognitive behavioral therapy. Electroencephalogram-neurofeedback (EEG-NF) training been suggested as non-invasive option with minimal side effects. In this systematic review, we summarize recent literature on EEG-NF treating depression. The 12 studies included in our final sample reported despite several issues related practices, patients showed significant cognitive, clinical, neural improvements following training. Given low cost risk of effects due nature, suggest worth exploring augmented tool who already receive standard medications but remain symptomatic, may be effective intervention can utilized supplementary We conclude by providing some suggestions experimental designs standards improve current practices

Language: Английский

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Neurofeedback and the Aging Brain: A Systematic Review of Training Protocols for Dementia and Mild Cognitive Impairment

Frontiers in Aging Neuroscience, Journal Year: 2021, Volume and Issue: 13

Published: June 9, 2021

Dementia describes a set of symptoms that occur in neurodegenerative disorders and is characterized by gradual loss cognitive behavioral functions. Recently, non-invasive neurofeedback training has been explored as potential complementary treatment for patients suffering from dementia or mild impairment. Here we systematically reviewed studies protocols based on electroencephalography functional magnetic resonance imaging these groups patients. From total 1,912 screened studies, 10 were included our final sample ( N = 208 independent participants experimental 81 the control completing primary endpoint). We compared clinical efficacy across evaluated their designs reporting quality. In most showed improved scores different tests. However, data randomized controlled trials remains scarce, evidence standardized metrics still inconclusive. light recent meta-research developments field beyond, quality practices individual are reviewed. conclude with recommendations best future investigate effects

Language: Английский

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The Current Evidence Levels for Biofeedback and Neurofeedback Interventions in Treating Depression: A Narrative Review

Neural Plasticity, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 31

Published: Feb. 4, 2021

This article is aimed at showing the current level of evidence for usage biofeedback and neurofeedback to treat depression along with a detailed review studies in field discussion rationale utilizing each protocol. La Vaque et al. criteria endorsed by Association Applied Psychophysiology Biofeedback International Society Neuroregulation & Research were accepted as means study evaluation. Heart rate variability (HRV) was found be moderately supportable treatment MDD while outcome measure subjective questionnaire like Beck Depression Inventory (level 3/5, “probably efficacious”). Electroencephalographic (EEG) protocols, namely, alpha-theta, alpha, sensorimotor rhythm upregulation, all qualify 2/5, “possibly efficacious.” Frontal alpha asymmetry protocol also received limited effect Finally, two most influential real-time functional magnetic resonance imaging (rt-fMRI) protocols targeting amygdala frontal cortices both demonstrate some effectiveness, though lack replications Thus, specifically supported existing (all fit The greatest complication preventing certain from reaching higher levels relatively high number uncontrolled an absence accurate arising heterogeneity details, course lengths, measures improvement, control conditions, sample characteristics.

Language: Английский

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Depressive symptoms reduce when dorsolateral prefrontal cortex-precuneus connectivity normalizes after functional connectivity neurofeedback

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Feb. 16, 2022

Abstract Depressive disorders contribute heavily to global disease burden; This is possibly because patients are often treated homogeneously, despite having heterogeneous symptoms with differing underlying neural mechanisms. A novel treatment that can directly influence the circuit relevant an individual patient’s subset of might more precisely and thus effectively aid in alleviation their specific symptoms. We tested this hypothesis a proof-of-concept study using fMRI functional connectivity neurofeedback. targeted between left dorsolateral prefrontal cortex/middle frontal gyrus precuneus/posterior cingulate cortex, connection has been well-established as relating depressive Specifically, shown data-driven manner be less anticorrelated melancholic depression than healthy controls. Furthermore, posterior dominant state—which results loss anticorrelation—is expected specifically relate increase rumination such brooding. In line predictions, we found that, neurofeedback training, participant normalized (restored anticorrelation), related (depressive brooding symptoms), but not unrelated (trait anxiety), were reduced. Because these look promising, paradigm next needs examined greater sample size better Nonetheless, here provide preliminary evidence for correlation normalization network reduction Showing reproducibility, two experiments took place several years apart by different experimenters. Indicative its potential clinical utility, effects remained one-two months later. Clinical trial registration : Both reported registered trials (UMIN000015249, jRCTs052180169).

Language: Английский

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Review on the Use of Brain Computer Interface Rehabilitation Methods for Treating Mental and Neurological Conditions

Journal of Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 23(7)

Published: July 5, 2024

This review provides a comprehensive examination of recent developments in both neurofeedback and brain-computer interface (BCI) within the medical field rehabilitation. By analyzing comparing results obtained with various tools techniques, we aim to offer systematic understanding BCI applications concerning different modalities input data utilized. Our primary objective is address existing gap area meta-reviews, which more outlook on field, allowing for assessment current landscape scope BCI. main methodologies include meta-analysis, search queries employing relevant keywords, network-based approach. We are dedicated delivering an unbiased evaluation studies, elucidating vectors research development this field. encompasses diverse range applications, incorporating use interfaces rehabilitation treatment diagnoses, including those related affective spectrum disorders. encompassing wide variety cases, perspective utilization treatments across contexts. The structured organized presentation information, complemented by accompanying visualizations diagrams, renders valuable resource scientists researchers engaged domains biofeedback interfaces.

Language: Английский

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Amygdala self-neuromodulation capacity as a window for process-related network recruitment

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2024, Volume and Issue: 379(1915)

Published: Oct. 21, 2024

Neurofeedback (NF) has emerged as a promising avenue for demonstrating process-related neuroplasticity, enabling self-regulation of brain function. NF targeting the amygdala drawn attention to therapeutic potential in psychiatry, by potentially harnessing emotion-regulation processes. However, not all individuals respond equally training, possibly owing varying abilities. This underscores importance understanding mechanisms behind successful neuromodulation (i.e. capacity). study aimed investigate establishment and neural correlates capacity using data from repeated sessions electrical fingerprint (Amyg-EFP)-NF post-training functional magnetic resonance imaging (fMRI)-NF sessions. Results 97 participants (healthy controls post-traumatic stress disorder fibromyalgia patients) revealed increased Amyg-EFP over associated with amygdala-fMRI modulation improvements alexithymia. Individual differenaces this were pre-training reactivity initial success. Additionally, downregulation during fMRI-NF co-modulated other regions such posterior insula parahippocampal gyrus. combined better explained EFP-modulation improvement alexithymia than alone, suggesting relevance broader network gained capacity. These findings support network-based approach highlight need consider individual differences function optimize interventions. article is part theme issue ‘Neurofeedback: new territories neurocognitive endogenous neuromodulation’.

Language: Английский

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