ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(17), P. 10979 - 11024
Published: April 18, 2024
Nanomaterials
have
attractive
physicochemical
properties.
A
variety
of
nanomaterials
such
as
inorganic,
lipid,
polymers,
and
protein
nanoparticles
been
widely
developed
for
nanomedicine
via
chemical
conjugation
or
physical
encapsulation
bioactive
molecules.
Superior
to
traditional
drugs,
nanomedicines
offer
high
biocompatibility,
good
water
solubility,
long
blood
circulation
times,
tumor-targeting
Capitalizing
on
this,
several
nanoformulations
already
clinically
approved
many
others
are
currently
being
studied
in
clinical
trials.
Despite
their
undoubtful
success,
the
molecular
mechanism
action
vast
majority
remains
poorly
understood.
To
tackle
this
limitation,
herein,
review
critically
discusses
strategy
applying
multiomics
analysis
study
nanomedicines,
named
nanomedomics,
including
advantages,
applications,
future
directions.
comprehensive
understanding
could
provide
valuable
insight
therefore
foster
development
translation
nanomedicines.
Asian Journal of Pharmaceutical Sciences,
Journal Year:
2023,
Volume and Issue:
18(6), P. 100854 - 100854
Published: Oct. 21, 2023
The
emergence
of
the
clustered
regularly
interspaced
short
palindromic
repeats
(CRISPR)/CRISPR-associated
protein
9
(Cas9)
genome-editing
system
has
brought
about
a
significant
revolution
in
realm
managing
human
diseases,
establishing
animal
models,
and
so
on.
To
fully
harness
potential
this
potent
gene-editing
tool,
ensuring
efficient
secure
delivery
to
target
site
is
paramount.
Consequently,
developing
effective
methods
for
CRISPR/Cas9
become
critical
area
research.
In
review,
we
present
comprehensive
outline
strategies
discuss
their
biomedical
applications
system.
We
also
provide
an
in-depth
analysis
physical,
viral
vector,
non-viral
vector
strategies,
including
plasmid-,
mRNA-
protein-based
approach.
addition,
illustrate
This
review
highlights
key
factors
affecting
process
current
challenges
facing
system,
while
delineating
future
directions
prospects
that
could
inspire
innovative
strategies.
aims
new
insights
ideas
advancing
CRISPR/Cas9-based
facilitate
breakthroughs
research
therapeutic
applications.
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Aug. 2, 2023
Abstract
Chemotherapy
remains
as
the
first-choice
treatment
option
for
triple-negative
breast
cancer
(TNBC).
However,
limited
tumor
penetration
and
low
cellular
internalization
efficiency
of
current
nanocarrier-based
systems
impede
access
anticancer
drugs
to
TNBC
with
dense
stroma
thereby
greatly
restricts
clinical
therapeutic
efficacy,
especially
bone
metastasis.
In
this
work,
biomimetic
head/hollow
tail
nanorobots
were
designed
through
a
site-selective
superassembly
strategy.
We
show
that
enable
efficient
remodeling
stromal
microenvironments
(TSM)
deep
penetration.
Furthermore,
self-movement
ability
spiky
head
markedly
promote
interfacial
uptake
transvascular
extravasation,
intratumoral
These
nanorobots,
which
integrate
penetration,
active
internalization,
near-infrared
(NIR)
light-responsive
release,
photothermal
therapy
capacities
into
single
nanodevice
efficiently
suppress
growth
in
metastasis
female
mouse
model
also
demonstrate
potent
antitumor
efficacy
three
different
subcutaneous
models.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Feb. 6, 2024
Abstract
Immunotherapy
with
immune
checkpoint
blockade
(ICB)
for
glioblastoma
(GBM)
is
promising
but
its
clinical
efficacy
seriously
challenged
by
the
blood-tumor
barrier
(BTB)
and
immunosuppressive
tumor
microenvironment.
Here,
anti-programmed
death-ligand
1
antibodies
(aPD-L1)
are
loaded
into
a
redox-responsive
micelle
ICB
further
amplified
paclitaxel
(PTX)-induced
immunogenic
cell
death
(ICD)
via
co-encapsulation
approach
reinvigoration
of
local
anti-GBM
responses.
Consequently,
micelles
cross
BTB
retained
in
reductive
microenvironment
without
altering
bioactivity
aPD-L1.
The
enhanced
aPD-L1
PTX
combination
suppression
primary
recurrent
GBM,
accumulation
cytotoxic
T
lymphocytes,
induction
long-lasting
immunological
memory
orthotopic
GBM-bearing
mice.
facilitating
efficient
antibody
delivery
combining
chemotherapeutic
agent-induced
ICD
demonstrate
that
chemo-immunotherapy
might
reprogram
immunity
to
empower
immunotherapy
against
GBM.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(17), P. 10979 - 11024
Published: April 18, 2024
Nanomaterials
have
attractive
physicochemical
properties.
A
variety
of
nanomaterials
such
as
inorganic,
lipid,
polymers,
and
protein
nanoparticles
been
widely
developed
for
nanomedicine
via
chemical
conjugation
or
physical
encapsulation
bioactive
molecules.
Superior
to
traditional
drugs,
nanomedicines
offer
high
biocompatibility,
good
water
solubility,
long
blood
circulation
times,
tumor-targeting
Capitalizing
on
this,
several
nanoformulations
already
clinically
approved
many
others
are
currently
being
studied
in
clinical
trials.
Despite
their
undoubtful
success,
the
molecular
mechanism
action
vast
majority
remains
poorly
understood.
To
tackle
this
limitation,
herein,
review
critically
discusses
strategy
applying
multiomics
analysis
study
nanomedicines,
named
nanomedomics,
including
advantages,
applications,
future
directions.
comprehensive
understanding
could
provide
valuable
insight
therefore
foster
development
translation
nanomedicines.
