Gastroenterology, Journal Year: 2019, Volume and Issue: 156(8), P. 2174 - 2189

Published: March 14, 2019

The intestinal microbiota is a dynamic community of bacteria, fungi, and viruses that mediates mucosal homeostasis physiology. Imbalances in the microbiome aberrant immune responses to gut bacteria can disrupt are associated with inflammatory bowel diseases (IBDs) humans colitis mice. We review genetic variants IBD their effects on microbiome, response, disease pathogenesis. which includes microbial antigens, adjuvants, metabolic products, affects development function mucosa, influencing gut. Therefore, strategies manipulate might be used treatment IBD. microbe-based therapies for potential engineer patients' microbiota. discuss how studies patients mouse models have advanced our understanding interactions between factors challenges Inflammatory include Crohn (CD) ulcerative (UC), chronic develop through complex among genetic, immune, environmental, factors.1Abraham C. Medzhitov R. 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