Plastoquinone synthesis inhibition by tetrabromo biphenyldiol as a widespread algicidal mechanism of marine bacteria DOI Creative Commons
Zenghu Zhang, Dehai Li, Ruize Xie

et al.

The ISME Journal, Journal Year: 2023, Volume and Issue: 17(11), P. 1979 - 1992

Published: Sept. 8, 2023

Abstract Algae and bacteria have complex intimate interactions in the ocean. Besides mutualism, evolved a variety of molecular-based anti-algal strategies. However, limited by unknown mechanism synthesis action these molecules, strategies their global prevalence remain unknown. Here we identify novel strategy through which marine representative Gammaproteobacteria produced 3,3’,5,5’-tetrabromo-2,2’-biphenyldiol (4-BP), that kills or inhibits diverse phytoplankton inhibiting plastoquinone its effect cascades to many other key metabolic processes algae. Through comparative genomic analysis between 4-BP-producing bacterium algicidally inactive mutant, combined with gene function verification, identified cluster responsible for 4-BP synthesis, contains genes encoding chorismate lyase, flavin-dependent halogenase cytochrome P450. We demonstrated near situ simulated algal blooming seawater, even low concentrations can cause changes overall community structure decline dinoflagellates diatoms. Further analyses sequences from Tara Oceans expeditions 2750 whole genome confirmed ubiquitous presence synthetic bacterial members ocean, suggesting it is tool potentially widely used oceans mediate bacteria-algae antagonistic relationships.

Language: Английский

Statistically learning the functional landscape of microbial communities DOI

Abigail Skwara,

Karna Gowda, Mahmoud Yousef

et al.

Nature Ecology & Evolution, Journal Year: 2023, Volume and Issue: 7(11), P. 1823 - 1833

Published: Oct. 2, 2023

Language: Английский

Citations

44
Algal blooms in the ocean: hot spots for chemically mediated microbial interactions DOI
Constanze Kuhlisch, Adva Shemi, Noa Barak-Gavish

et al.

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 22(3), P. 138 - 154

Published: Oct. 13, 2023

Language: Английский

Citations

44
An atlas of metabolites driving chemotaxis in prokaryotes DOI Creative Commons
Maéva Brunet, Shady A. Amin, Iurii Bodachivskyi

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 1, 2025

Language: Английский

Citations

2
Chemodiversity of Dissolved Organic Matter Is Governed by Microbial Biogeography in Inland Waters DOI
Wanzhu Li, Na Liu, Jianfeng Li

et al.

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(20), P. 7753 - 7763

Published: May 10, 2023

Dissolved organic matter (DOM) is crucial for the carbon biogeochemical cycle and has a close link with microbiome in aquatic ecosystems; however, causal relationship between DOM microbial diversity inland waters not very clear so far. Therefore, national survey of China's was conducted, chemical composition community were determined by Fourier transform ion cyclotron resonance mass spectrometry high-throughput sequencing to clarify abovementioned question. Here, we found that chemodiversity governed assembly waters, vice versa. Under control biogeography, showed geographical distribution difference. Water mainly constrained bacterial archaeal composition, whereas sediment controlled eukaryotic fungal composition. In addition, also affected interaction different groups sediments. The study first proposes regulatory mechanism on pattern chemodiversity, thus further deepening understanding cycle.

Language: Английский

Citations

34
The role of microbiomes in gastrointestinal cancers: new insights DOI Creative Commons
Aref Yarahmadi, Hamed Afkhami

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 13

Published: Feb. 1, 2024

Gastrointestinal (GI) cancers constitute more than 33% of new cancer cases worldwide and pose a considerable burden on public health. There exists growing body evidence that has systematically recorded an upward trajectory in GI malignancies within the last 5 to 10 years, thus presenting formidable menace health human population. The perturbations microbiota may have noteworthy influence advancement cancers; however, precise mechanisms behind this association are still not comprehensively understood. Some bacteria been observed support development, while others seem provide safeguard against it. Recent studies indicated alterations composition abundance microbiomes could be associated with progression various cancers, such as colorectal, gastric, hepatic, esophageal cancers. Within comprehensive analysis, we examine significance microbiomes, particularly those located intestines, Furthermore, explore impact treatment modalities for cancer, including chemotherapy, immunotherapy, radiotherapy. Additionally, delve into intricate through which intestinal microbes efficacy treatments.

Language: Английский

Citations

12
Microbial strategies driving low concentration substrate degradation for sustainable remediation solutions DOI Creative Commons
Qidong Yin, Kai He, Gavin Collins

et al.

npj Clean Water, Journal Year: 2024, Volume and Issue: 7(1)

Published: June 25, 2024

Abstract Microbial metabolism upholds a fundamental role in the sustainability of water ecosystems. However, how microorganisms surviving low-concentration substrate environments, including existence emerging compounds interest, remains unclear. In this review, microbial strategies for concentrating, utilizing, and metabolizing low concentration substrates were summarized. Microorganisms develop substrate-concentrating at both cell aggregate levels substrate-limited settings. Following, uptake transport are facilitated by adjusting physiological characteristics shifting affinities. Finally, metabolic pathways, such as mixed-substrate utilization, syntrophic metabolism, dynamic response to nutrient variation, population density-based mechanisms allow efficiently utilize adapt challenging oligotrophic environments. All these will underpin devising new approaches tackle environmental challenges drive ecosystems, particularly managing contaminants (i.e., micropollutants).

Language: Английский

Citations

11
Adaptive expression of phage auxiliary metabolic genes in paddy soils and their contribution toward global carbon sequestration DOI Creative Commons
Dong Zhu, Shuyue Liu, Mingming Sun

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(49)

Published: Nov. 27, 2024

Habitats with intermittent flooding, such as paddy soils, are crucial reservoirs in the global carbon pool; however, effect of phage–host interactions on biogeochemical cycling soils remains unclear. Hence, this study applied multiomics and datasets integrated validation experiments to investigate community potential phages impact sequestration soils. The results demonstrated that soil harbor a diverse abundant repertoire auxiliary metabolic genes (AMGs) associated fixation, comprising 23.7% identified AMGs. successful annotation protein structures promoters further suggested an elevated expression these within their bacterial hosts. Moreover, environmental stressors, heavy metal contamination, cause genetic variation up-regulate fixation AMGs, by significant enrichment related metabolites ( P < 0.05). Notably, findings indicate lysogenic infecting carbon-fixing hosts increased 10.7% under stress. In addition, situ isotopic labeling induced mitomycin-C revealed increasing concentrations, 13 CO 2 emissions from treatment added phage decreased approximately 17.9%. contrast, C-labeled microbial biomass content average 35.4% compared control. These suggest prominently influence cycle, particularly change conditions. This research enhances our understanding cooperation driving amid evolving

Language: Английский

Citations

11
Unveiling the deterministic dynamics of microbial meta-metabolism: a multi-omics investigation of anaerobic biodegradation DOI Creative Commons
Xingsheng Yang, Kai Feng, Shang Wang

et al.

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: Sept. 7, 2024

Language: Английский

Citations

9
Relating Dimethyl Sulphide and Methanethiol Fluxes to Surface Biota in the South‐West Pacific Using Shipboard Air‐Sea Interface Tanks DOI Creative Commons
Manon Rocco, Erin Dunne, Romain Salignat

et al.

Journal of Geophysical Research Atmospheres, Journal Year: 2025, Volume and Issue: 130(1)

Published: Jan. 7, 2025

Abstract Dimethyl sulphide (DMS) and methanethiol (MeSH) emissions from South Pacific surface seawater were determined in deck board Air‐Sea Interface Tanks during the Sea2Cloud voyage March 2020. The measured fluxes water to headspace (F) varied with mass type, lowest observed Subtropical Subantarctic waters highest Frontal waters. Measured DMS consistent calculated using a two‐layer model concentrations. MeSH:DMS flux ratio was 11%–18% across three types, confirming that MeSH may represent significant unaccounted contribution atmospheric sulfur budget, potentially important implications for marine aerosol formation growth models. Combining data ASITs ambient identified Spearman rank correlations both dissolved nanophytoplankton cell abundance ( p value < 0.012), suggesting an role this phytoplankton size class determining regional emissions. Applying nanophytoplankton‐based parameterization estimate w provided good agreement recent climatology. Consequently, relationship between , abundances be applicable modeling fluxes.

Language: Английский

Citations

1
Uptake of Prochlorococcus-derived metabolites by Alteromonas macleodii MIT1002 shows high levels of substrate specificity DOI Creative Commons
Kathryn H. Halloran, Rogier Braakman, Allison Coe

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Abstract Seawater contains an abundance of small biomolecules, or metabolites, that are highly labile components dissolved organic matter (DOM). Marine microbes interact by exchanging thus shaping marine microbial ecology, DOM composition, and global carbon cycling. To better constrain one set microbe-metabolite interactions, we cultured the gammaproteobacterium Alteromonas macleodii MIT1002 on a range compounds excreted sympatric cyanobacterium, Prochlorococcus . could assimilate branched chain amino acids leucine, isoleucine, valine, as well 3-methyl-2-oxobutanoic acid (a ketoacid intermediate valine metabolism), but not thymidine, kynurenine, 4-hydroxybenzoic acid, other ketoacids. The assimilation indicates can metabolically process each corresponding ketoacid, suggesting transporter specificity underlies observed substrate for acid. These experiments show even subtle changes in chemical structure result different interactions fates metabolites. Significance Statement Microbial with important controls cycle. Dissolved is often considered bulk, which leaves nature these poorly constrained. Here microbe-molecule be specific, distinguishing between molecules structurally biochemically similar. This implies this pool have large impacts overall system function, measuring molecular-level resolution to characterizing interactions. We further explore mechanism underlying suggest it caused selectivity, meaning ability selectively uptake specific molecules.

Language: Английский

Citations

1