Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Dec. 17, 2022
Abstract
Methods
capable
of
manipulating
bacterial
colonization
are
great
significance
for
modulating
host-microbiota
relationships.
Here,
we
describe
a
strategy
in-situ
chemical
reaction-mediated
covalent
localization
bacteria.
Through
simple
one-step
imidoester
reaction,
primary
amino
groups
on
surface
can
be
converted
to
free
thiols
under
cytocompatible
conditions.
Surface
thiolation
is
applicable
modify
diverse
strains
and
the
number
introduced
per
bacterium
easily
tuned
by
varying
feed
ratios.
These
chemically
reactive
bacteria
able
spontaneously
bond
with
mucous
layer
catalyst-free
thiol-disulfide
exchange
between
mucin-associated
disulfides
newly
show
level-dependent
attachment.
Bacteria
optimized
9.3
×
10
7
cell
achieve
170-fold
higher
attachment
in
mucin-enriched
jejunum,
challenging
location
gut
microbiota
colonize.
As
proof-of-concept
application
transplantation,
bonding-assisted
an
oral
probiotic
jejunum
generates
improved
remission
jejunal
mucositis.
Our
findings
demonstrate
that
transforming
provides
approach
control
localization,
which
highly
desirable
developing
next-generation
living
bioagents.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(19), P. 6617 - 6643
Published: Jan. 1, 2023
This
review
summarizes
the
strategies
for
surface
chemical
modification
of
bacteria
and
advanced
functions
achieved
by
modifying
specific
components
highlights
applications
modified
bioimaging,
diagnosis,
therapy.
European Journal of Pharmaceutical Sciences,
Journal Year:
2023,
Volume and Issue:
188, P. 106515 - 106515
Published: July 2, 2023
Microbial
resistance
has
increased
in
recent
decades
as
a
result
of
the
extensive
and
indiscriminate
use
antibiotics.
The
World
Health
Organization
listed
antimicrobial
one
ten
major
global
public
health
threats
2021.
In
particular,
six
bacterial
pathogens,
including
third-generation
cephalosporin-resistant
Escherichia
coli,
methicillin-resistant
Staphylococcus
aureus,
carbapenem-resistant
Acinetobacter
baumannii,
Klebsiella
pneumoniae,
Streptococcus
Pseudomonas
aeruginosa,
were
found
to
have
highest
resistance-related
death
rates
2019.
To
respond
this
urgent
call,
creation
new
pharmaceutical
technologies
based
on
nanoscience
drug
delivery
systems
appears
be
promising
strategy
against
microbial
light
advancements,
particularly
knowledge
medicinal
biology.
Nanomaterials
are
often
defined
substances
having
sizes
between
1
100
nm.
If
material
is
used
small
scale;
its
properties
significantly
change.
They
come
variety
forms
help
provide
distinguishing
characteristics
for
wide
range
functions.
field
sciences
demonstrated
strong
interest
numerous
nanotechnology
applications.
Therefore,
review,
prospective
nanotechnology-based
therapeutics
management
infections
with
multiple
medication
critically
examined.
Recent
developments
these
innovative
treatment
techniques
described,
an
emphasis
preclinical,
clinical,
combinatorial
approaches.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(37), P. 33358 - 33366
Published: Sept. 7, 2023
Recently,
nanobiotechnology
has
attracted
a
lot
of
attention,
as
it
is
rapidly
emerging
field
that
still
growing
and
developing
efficient
advanced
therapeutic
protocols
under
the
umbrella
nanomedicine.
It
can
revolutionize
solutions
to
biomedical
problems
by
effective
treatment
therapeutics.
However,
focus
research
are
required
make
these
therapeutics
more
safer
use.
In
this
study,
iron
oxide
nanoparticles
were
synthesized
from
Madhuca
indica
extract
using
green
synthesis
protocols.
The
further
characterized
based
on
their
absorption
spectrum,
size,
structural
morphology,
other
related
parameters.
Biological
assays
also
performed
evaluate
biological
applications
for
nanoparticles.
silico
analysis
was
assess
druglike
properties
results
proved
an
optimized
with
size
56
nm
confirmed
SEM.
FTIR
predicted
presence
nitro
carbonyl
groups
in
81%
DPPH
inhibition
antioxidant
activity,
96.20%
egg
albumin
protein
anti-inflamatory
activity.
Additionally,
73.26%
α-amylase,
which
than
control
used,
antidiabetic
ADMET
potential
candidates
well.
evaluation
safety
concerns
use
FeONPs
agents.
This
study
be
significant
contribution
scientific
community
gateway
future
scientists
who
willing
work
nanomedicine
nanobiotechnology.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(17), P. 10979 - 11024
Published: April 18, 2024
Nanomaterials
have
attractive
physicochemical
properties.
A
variety
of
nanomaterials
such
as
inorganic,
lipid,
polymers,
and
protein
nanoparticles
been
widely
developed
for
nanomedicine
via
chemical
conjugation
or
physical
encapsulation
bioactive
molecules.
Superior
to
traditional
drugs,
nanomedicines
offer
high
biocompatibility,
good
water
solubility,
long
blood
circulation
times,
tumor-targeting
Capitalizing
on
this,
several
nanoformulations
already
clinically
approved
many
others
are
currently
being
studied
in
clinical
trials.
Despite
their
undoubtful
success,
the
molecular
mechanism
action
vast
majority
remains
poorly
understood.
To
tackle
this
limitation,
herein,
review
critically
discusses
strategy
applying
multiomics
analysis
study
nanomedicines,
named
nanomedomics,
including
advantages,
applications,
future
directions.
comprehensive
understanding
could
provide
valuable
insight
therefore
foster
development
translation
nanomedicines.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Jan. 18, 2024
Abstract
A
safe
and
effective
vaccine
with
long-term
protection
against
SARS-CoV-2
variants
of
concern
(VOCs)
is
a
global
health
priority.
Here,
we
develop
lipid
nanoparticles
(LNPs)
to
provide
delivery
plasmid
DNA
(pDNA)
show
VOCs
in
female
small
animal
models.
Using
library
LNPs
encapsulating
unique
barcoded
(b-DNA),
screen
for
b-DNA
after
intramuscular
administration.
The
top-performing
are
further
tested
their
capacity
pDNA
uptake
antigen-presenting
cells
vitro.
lead
LNP
used
encapsulate
encoding
the
HexaPro
version
spike
(LNP-HPS)
immunogenicity
vivo.
LNP-HPS
elicit
robust
protective
effect
Gamma
(P.1),
correlating
reduced
lethality,
decreased
viral
load
lungs
lung
damage.
induce
potent
humoral
T
cell
responses
P.1,
generate
high
levels
neutralizing
antibodies
P.1
Omicron
(B.1.1.529).
Our
findings
indicate
that
efficacy
elicited
by
comparable
those
achieved
approved
COVID-19
from
Biontech/Pfizer
Together,
these
suggest
hold
great
promise
as
candidate
VOCs.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 17, 2025
Since
their
inception
in
the
early
1960s,
development
and
use
of
nanoscale
materials
have
progressed
tremendously,
roles
diverse
fields
ranging
from
human
health
to
energy
electronics
are
undeniable.
The
application
nanotechnology
inventions
has
revolutionized
many
aspects
everyday
life
including
various
medical
applications
specifically
drug
delivery
systems,
maximizing
therapeutic
efficacy
contained
drugs
by
means
bioavailability
enhancement
or
minimization
adverse
effects.
In
this
review,
we
utilize
CAS
Content
Collection,
a
vast
repository
scientific
information
extracted
journal
patent
publications,
analyze
trends
nanoscience
research
relevant
an
effort
provide
comprehensive
detailed
picture
field.
We
examine
publication
landscape
area
insights
into
current
knowledge
advances
developments.
review
major
classes
nanosized
routes,
targeted
diseases.
outline
most
discussed
concepts
assess
advantages
nanocarriers.
objective
is
broad
overview
evolving
regarding
challenges,
evaluate
growth
opportunities.
merit
stems
extensive,
wide-ranging
coverage
up-to-date
information,
allowing
unmatched
breadth
analysis
in-depth
insights.
