Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Dec. 17, 2022
Abstract
Methods
capable
of
manipulating
bacterial
colonization
are
great
significance
for
modulating
host-microbiota
relationships.
Here,
we
describe
a
strategy
in-situ
chemical
reaction-mediated
covalent
localization
bacteria.
Through
simple
one-step
imidoester
reaction,
primary
amino
groups
on
surface
can
be
converted
to
free
thiols
under
cytocompatible
conditions.
Surface
thiolation
is
applicable
modify
diverse
strains
and
the
number
introduced
per
bacterium
easily
tuned
by
varying
feed
ratios.
These
chemically
reactive
bacteria
able
spontaneously
bond
with
mucous
layer
catalyst-free
thiol-disulfide
exchange
between
mucin-associated
disulfides
newly
show
level-dependent
attachment.
Bacteria
optimized
9.3
×
10
7
cell
achieve
170-fold
higher
attachment
in
mucin-enriched
jejunum,
challenging
location
gut
microbiota
colonize.
As
proof-of-concept
application
transplantation,
bonding-assisted
an
oral
probiotic
jejunum
generates
improved
remission
jejunal
mucositis.
Our
findings
demonstrate
that
transforming
provides
approach
control
localization,
which
highly
desirable
developing
next-generation
living
bioagents.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(11), P. 18505 - 18519
Published: Nov. 5, 2021
Large
doses
and
long
duration
are
often
required
for
herbal
medicines
to
kill
bacteria
effectively.
Herein,
a
photoacoustic
interfacial
engineering
strategy
was
utilized
endow
curcumin
(Cur,
kind
of
medicine)
with
rapid
highly
effective
bacteria-killing
efficacy,
in
which
Cur
combined
CuS
form
hybrid
material
CuS/Cur
tight
contact
through
situ
nucleation
growth
on
the
petaloid
surface.
Due
different
work
functions
Cur,
electrons
were
redistributed,
i.e.,
large
number
gathered
side
CuS.
In
contrast,
holes
after
contact.
An
internal
electric
field
formed
drive
excited
transfer
from
thus
enhancing
separation
electron–hole
pairs.
Besides
exerting
drug
nature
itself,
also
had
photo–sono
responsive
ability,
endowed
photothermal,
photodynamic,
sonodynamic
effects.
Therefore,
this
Cur-based
killed
99.56%
Staphylococcus
aureus
99.48%
Escherichia
coli
under
808
nm
near-infrared
light
irradiation
ultrasound
successively
15
min,
ascribed
synergy
ROS,
hyperthermia,
released
Cu2+
together
properties
Cur.
This
provides
enhance
therapeutic
effects
against
pathogenic
bacterial
infections
by
exciting
intrinsic
as
materials
strategy.
Nanomaterials,
Journal Year:
2022,
Volume and Issue:
12(11), P. 1855 - 1855
Published: May 29, 2022
Infectious
diseases
are
among
the
major
health
issues
of
21st
century.
The
substantial
use
antibiotics
over
years
has
contributed
to
dissemination
multidrug
resistant
bacteria.
According
a
recent
report
by
World
Health
Organization,
antibacterial
(ATB)
drug
resistance
been
one
biggest
challenges,
as
well
development
effective
long-term
ATBs.
Since
pathogens
quickly
adapt
and
evolve
through
several
strategies,
regular
ATBs
usually
may
result
in
temporary
or
noneffective
treatments.
Therefore,
demand
for
new
therapies
methods,
such
nano-drug
delivery
systems
(NDDS),
aroused
huge
interest
due
its
potentialities
improve
bioavailability
targeting
efficiency,
including
liposomes,
nanoemulsions,
solid
lipid
nanoparticles,
polymeric
metal
others.
Given
relevance
this
subject,
review
aims
summarize
progress
research
therapeutic
drugs
supported
nanobiotechnological
tools.
Nanomaterials,
Journal Year:
2021,
Volume and Issue:
11(5), P. 1251 - 1251
Published: May 10, 2021
Antimicrobial
resistance
is
one
of
the
biggest
threats
to
global
health
as
current
antibiotics
are
becoming
useless
against
resistant
infectious
pathogens.
Consequently,
new
antimicrobial
strategies
urgently
required.
Drug
delivery
systems
represent
a
potential
solution
improve
antibiotic
properties
and
reverse
mechanisms.
Among
different
drug
systems,
solid
lipid
nanoparticles
highly
interesting
option
they
offer
many
advantages
for
nontoxic
targeted
delivery.
Several
publications
have
demonstrated
capacity
SLNs
significantly
characteristics
increasing
treatment
efficiency.
In
this
review
article,
antibiotic-loaded
nanoparticle-related
works
analyzed
summarize
all
information
associated
with
applying
these
formulations
tackle
problem.
The
main
mechanisms
relevant
nanoparticle
presented
later
discuss
overcome
Moreover,
also
possibilities
other
agents
that
cannot
be
administrated
free
drugs.
disadvantages
discussed
in
review.
Finally,
given
progress
studies
carried
out
date,
future
directions
discussed.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Dec. 17, 2022
Abstract
Methods
capable
of
manipulating
bacterial
colonization
are
great
significance
for
modulating
host-microbiota
relationships.
Here,
we
describe
a
strategy
in-situ
chemical
reaction-mediated
covalent
localization
bacteria.
Through
simple
one-step
imidoester
reaction,
primary
amino
groups
on
surface
can
be
converted
to
free
thiols
under
cytocompatible
conditions.
Surface
thiolation
is
applicable
modify
diverse
strains
and
the
number
introduced
per
bacterium
easily
tuned
by
varying
feed
ratios.
These
chemically
reactive
bacteria
able
spontaneously
bond
with
mucous
layer
catalyst-free
thiol-disulfide
exchange
between
mucin-associated
disulfides
newly
show
level-dependent
attachment.
Bacteria
optimized
9.3
×
10
7
cell
achieve
170-fold
higher
attachment
in
mucin-enriched
jejunum,
challenging
location
gut
microbiota
colonize.
As
proof-of-concept
application
transplantation,
bonding-assisted
an
oral
probiotic
jejunum
generates
improved
remission
jejunal
mucositis.
Our
findings
demonstrate
that
transforming
provides
approach
control
localization,
which
highly
desirable
developing
next-generation
living
bioagents.
