Versatile Polycaprolactone-Based Drug Delivery System with Enhanced Cytocompatibility and Antibacterial Activity DOI Creative Commons

Celine Guder,

Anja Hofmann,

Therese Schüler

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(5), P. 182 - 182

Published: May 15, 2025

Common antibiotic therapies to treat bacterial infections are associated with systemic side effects and the development of resistance, directly connected duration dosage. Local drug delivery systems (DDSs) offer an alternative by localising antibiotics thereby limiting their while reducing dosage necessary. A biodegradable polyester polycaprolactone (PCL)-based DDS was thus produced, containing various clinically relevant drugs. It shown that incorporation four distinct classes (amoxicillin, doxycycline, metronidazole rifampicin), very high mass fractions ranging up 20 wt%, feasible within PCL matrix. This showed capacity for effective sustained release. The release kinetics over 14 days were proven, showing a significant decrease in cytotoxicity smooth muscle cells as well antibacterial effect on (1) aerobic, (2) anaerobic, (3) Gram-positive (4) Gram-negative pathogens vitro. demonstrated markedly diminished cytotoxic impact owing comparison pure antibiotics, simultaneously maintaining efficacy. In conclusion, DDSs more tolerable form administration due hydrophobic matrix causing slower diffusion-controlled release, proven mechanism via Peppa–Sahlin model.

Language: Английский

Antibiotic adjuvants: synergistic tool to combat multi-drug resistant pathogens DOI Creative Commons
Vikram Kumar,

Nusrath Yasmeen,

Aishwarya Pandey

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: Dec. 20, 2023

The rise of multi-drug resistant (MDR) pathogens poses a significant challenge to the field infectious disease treatment. To overcome this problem, novel strategies are being explored enhance effectiveness antibiotics. Antibiotic adjuvants have emerged as promising approach combat MDR by acting synergistically with This review focuses on role antibiotic synergistic tool in fight against pathogens. Adjuvants refer compounds or agents that activity antibiotics, either potentiating their effects targeting mechanisms resistance. utilization offers several advantages. Firstly, they can restore existing antibiotics strains. inhibit confer resistance, making susceptible action Secondly, improving penetration into bacterial cells, increasing stability, inhibiting efflux pumps expel from cells. Various types been investigated, including pump inhibitors, resistance-modifying agents, and disrupt biofilms. These act resulting increased antibacterial overcoming resistance mechanisms. In conclusion, potential revolutionize treatment By enhancing efficacy offer strategy growing threat Further research development crucial harness full bring them closer clinical application.

Language: Английский

Citations

46
Recent Advances in the Development of Antibiotics-Coated Gold Nanoparticles to Combat Antimicrobial Resistance DOI Creative Commons
Partha Pratim Sarma, Akhilesh Rai, Pranjal K. Baruah

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(2), P. 124 - 124

Published: Jan. 26, 2024

Antimicrobial resistance (AMR) has become an alarming threat to the successful treatment of rapidly growing bacterial infections due abuse and misuse antibiotics. Traditional antibiotics bear many limitations, including restricted bioavailability, inadequate penetration emergence antimicrobial-resistant microorganisms. Recent advances in nanotechnology for introduction nanoparticles with fascinating physicochemical characteristics have been predicted as innovative means defence against diseases. The use provides several benefits, improved tissue targeting, better solubility, stability, enhanced epithelial permeability causes minimal side effects. However, except gold (AuNPs), biological safety majority metal remains a serious problem. AuNPs appear be promising drug delivery medicinal applications because their toxicity, biocompatibility, functional flexibility, chemical stability versatile activities, such antiviral, antifungal, anti-inflammatory antimicrobial properties. Hence, we are focusing on possessing activity this article. This review will cover recent strategies preparation nanoparticles, special emphasis placed antibiotics-coated properties how they fight disease-causing bacteria eradicate biofilms, along activities

Language: Английский

Citations

19
Cefazolin encapsulated UIO-66-NH2 nanoparticles enhance the antibacterial activity and biofilm inhibition against drug-resistant S. aureus: In vitro and in vivo studies DOI

Amirhossein Dastneshan,

Shabnam Rahiminezhad,

Maryam Naderi Mezajin

et al.

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 455, P. 140544 - 140544

Published: Nov. 24, 2022

Language: Английский

Citations

65
Biodegradable Polymers and Polymer Composites with Antibacterial Properties DOI Open Access

A. Smola,

Kamila Lewicka, Alicja Macyk

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7473 - 7473

Published: April 18, 2023

Antibiotic resistance is one of the greatest threats to global health and food security today. It becomes increasingly difficult treat infectious disorders because antibiotics, even newest ones, are becoming less effective. One ways taken in Global Plan Action announced at World Health Assembly May 2015 ensure prevention treatment diseases. In order do so, attempts made develop new antimicrobial therapeutics, including biomaterials with antibacterial activity, such as polycationic polymers, polypeptides, polymeric systems, provide non-antibiotic therapeutic agents, selected biologically active nanoparticles chemical compounds. Another key issue preventing from contamination by developing packaging materials, particularly based on degradable polymers biocomposites. This review, a cross-sectional way, describes most significant research activities conducted recent years field development materials polymer composites properties. We focus natural i.e., polysaccharides which present mechanism for combating many highly pathogenic microorganisms. also attempt use this knowledge obtain synthetic similar activity.

Language: Английский

Citations

37
Esterification modification of graphene oxide for Metronidazole release: Optimization and modelling using response surface methodology and artificial neural Networks DOI
Niloufar Torabi Fard, Homayon Ahmad Panahi, Elham Moniri

et al.

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 399, P. 124393 - 124393

Published: March 6, 2024

Language: Английский

Citations

13
Resveratrol/Selenium Nanocomposite with Antioxidative and Antibacterial Properties DOI Creative Commons
Nina Tomić, Magdalena Stevanović, Nenad Filipović

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(4), P. 368 - 368

Published: Feb. 16, 2024

In this work, we synthesized a new composite material comprised of previously formulated resveratrol nanobelt-like particles (ResNPs) and selenium nanoparticles (SeNPs), namely ResSeNPs. Characterization was provided by FESEM optical microscopy, as well UV-Vis FTIR spectroscopy, the last showing hydrogen bonds between ResNPs SeNPs. DPPH, TBA, FRAP assays showed excellent antioxidative abilities with SeNPs contributing mainly to lipid peroxidation inhibition reducing/scavenging activity, respectively. The antibacterial effect against common medicinal implant colonizers pointed notably higher activity

Language: Английский

Citations

10
Inhibition of Polymicrobial Biofilms of Candida albicans–Staphylococcus aureus/Streptococcus mutans by Fucoidan–Gold Nanoparticles DOI Creative Commons
Nazia Tabassum, Fazlurrahman Khan,

Min-Gyun Kang

et al.

Marine Drugs, Journal Year: 2023, Volume and Issue: 21(2), P. 123 - 123

Published: Feb. 13, 2023

The polymicrobial proliferation and development of complex biofilm morphologies by bacterial fungal pathogens in the host are some key factors contributing to failure antimicrobial treatments. interaction Candida albicans species has been extensively studied both vitro vivo model systems. Alternative strategies for disrupting formation constantly needed. Among several alternative strategies, use nanoparticles synthesized using a natural product treatment microbial infection considered promising approach. current study aimed synthesize gold (AuNPs) product, fucoidan, test their efficacy against mono duo combinations (Candida albicans) (Staphylococcus aureus/Streptococcus mutans) biofilms. Several methods were used characterize Fu–AuNPs, including UV-vis absorption spectroscopy, FTIR, FE-TEM, EDS, DLS, zeta potential, XRD. concentration-dependent inhibition early-stage biofilms eradication mature single C. albicans, S. aureus, mutans have observed. Early dual-species combination aureus/S. also suppressed at an increasing concentration Fu–AuNPs. Furthermore, Fu–AuNPs significantly eradicated established mixed species. method proposed this study, which involves marine-bioinspired nanoparticles, is biocompatible agent preventing growth pathogens.

Language: Английский

Citations

22
Advancements in Nanoparticle-Based Strategies for Enhanced Antibacterial Interventions DOI
Madineh Moradialvand, Nastaran Asri,

Mahtab Jahdkaran

et al.

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 82(4), P. 3071 - 3090

Published: July 18, 2024

Language: Английский

Citations

8
Synthesis and characterization of silver nanoparticles developed using a novel lipopeptide(s) biosurfactant and evaluating its antimicrobial and cytotoxic efficacy. DOI
Vivek Chauhan, Vivek Kumar Dhiman,

Gaytri Mahajan

et al.

Process Biochemistry, Journal Year: 2022, Volume and Issue: 124, P. 51 - 62

Published: Nov. 8, 2022

Language: Английский

Citations

25
Antibiotic-Loaded Nano-Sized Delivery Systems: An Insight into Gentamicin and Vancomycin DOI Creative Commons
Silvia Pisani,

Shafia Tufail,

Mariella Rosalia

et al.

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(7), P. 194 - 194

Published: July 15, 2024

The fight against infectious disease has remained an ever-evolving challenge in the landscape of healthcare. ability pathogens to develop resistance conventional drug treatments decreased effectiveness therapeutic interventions, and antibiotic is recognized as one main challenges our time. goal this systematic review paper provide insight into research papers published on innovative nanosized delivery systems (DDSs) based gentamycin vancomycin discuss opportunity their repurposing through nano DDS formulations. These two antibiotics are selected because (i) gentamicin first-line used treat suspected or confirmed infections caused by Gram-negative bacterial (ii) serious Gram-positive infections. Moreover, both have severe adverse effects, purposes formulation DDSs overcome them. includes introduction focusing diseases traditional treatments, a brief description chemical pharmacological properties vancomycin, case studies from literature carriers drugs, discussion results found literature.

Language: Английский

Citations

6