Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 259, P. 155346 - 155346
Published: May 11, 2024
Language: Английский
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(51)
Published: Aug. 26, 2024
Abstract Pathogenic infectious diseases have persistently posed significant threats to public health. Phototheranostics, which combines the functions of diagnostic imaging and therapy, presents an extremely promising solution block spread pathogens as well outbreak epidemics owing its merits a wide‐spectrum activity, high controllability, non‐invasiveness, difficult acquire resistance. Among multifarious phototheranostic agents, second near‐infrared (NIR‐II, 1000–1700 nm) aggregation‐induced emission luminogens (AIEgens) are notable by virtue their deep penetration depth, excellent biocompatibility, balanced radiative nonradiative decay aggregation‐enhanced theranostic performance, making them ideal option for combating pathogens. This minireview provides systematical summary latest advancements in NIR‐II AIEgens with emphasis on molecular design nanoplatform formulation fulfill high‐efficiency treating bacterial viral pathogens, classified disease models. Then, current challenges, potential opportunities, future research directions presented facilitate further progress this emerging field.
Language: Английский
Citations
6
Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(4), P. 042003 - 042003
Published: May 13, 2024
Abstract Infectious diseases severely threaten human health, and traditional treatment techniques face multiple limitations. As an important component of immune cells, macrophages display unique biological properties, such as biocompatibility, immunocompatibility, targeting specificity, immunoregulatory activity, play a critical role in protecting the body against infections. The macrophage membrane-coated nanoparticles not only maintain functions inner but also inherit characteristics macrophages, making them excellent tools for improving drug delivery therapeutic implications infectious (IDs). In this review, we describe their advantages challenges ID therapy. We first summarize pathological features IDs, providing insight into how to fight them. Next, focus on classification, characteristics, preparation nanoparticles. Finally, comprehensively progress combating including delivery, inhibition killing pathogens, modulation. At end look forward aspect is presented.
Language: Английский
Citations
5
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(38)
Published: July 30, 2024
Small-interfering RNAs (siRNAs) offer promising prospects for treating pyroptosis-related autoimmune diseases. However, poor stability and off-target effects during in vivo transportation hinder their practical clinical applications. Precision delivery adaptive release of siRNAs into inflamed tissues immune cells could unleash full therapeutic potential. This study establishes a pyroptotic-spatiotemporally selective siRNA system (PMRC@siGSDME) that selectively targets inflammatory tissues, responds to pyroptosis, exhibits remarkable efficacy against various Novel hybrid nanovesicles (NVs) are designed as combination pyroptotic macrophage membranes (PMs) R8-cardiolipin-containing (RC-NVs). Evidence provides PM-derived proteins involved cell-cell interactions membrane trafficking may contribute the specificity NVs tissue. In addition, cardiolipin anchored increases its affinity activated gasdermin E (GSDME) achieves pyroptosis-adaptive siGSDME spatiotemporally suppression responses. More importantly, PMRC@siGSDME displays significant anti-inflammatory multiple mouse disease models, including arthritis bowel (IBD). Collectively, an innovative strategy precisely tailored has been developed, paving way new treatments diseases with minimal side wide applicability.
Language: Английский
Citations
5
Materials Today Bio, Journal Year: 2024, Volume and Issue: 28, P. 101232 - 101232
Published: Sept. 10, 2024
Language: Английский
Citations
5
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 259, P. 155346 - 155346
Published: May 11, 2024
Language: Английский
Citations
4