Anisotropic Hydrogel Microelectrodes for Intraspinal Neural Recordings in vivo DOI Creative Commons
Siyuan Rao, Sizhe Huang,

Ruobai Xiao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 14, 2024

Abstract Creating durable, motion-compliant neural interfaces is crucial for accessing dynamic tissues under in vivo conditions and linking activity with behaviors. Utilizing the self-alignment of nano-fillers a polymeric matrix repetitive tension, here, we introduce conductive carbon nanotubes high aspect ratios into semi-crystalline polyvinyl alcohol hydrogels create electrically anisotropic percolation pathways through cyclic stretching. The resulting hydrogel fibers (diameter 187 ± 13 µm) exhibit fatigue resistance (20,000 cycles at 20% strain) stretchability 64.5 7.9%, low electrochemical impedance (900 149 kΩ @ 1kHz). We observe re-constructed nanofillers’ axial alignment corresponding decrease along direction fabricate fiber-shaped bioelectronic devices implant them wild-type transgenic Thy1-ChR2-EYFP mice to record electromyographic signals from muscles anesthetized freely moving conditions. These effectively enable simultaneous recording electrical ventral spinal cord neurons tibialis anterior during optogenetic stimulation. Importantly, maintain functionality repeatable results over eight months after implantation, demonstrating their durability potential long-term monitoring neurophysiological studies.

Language: Английский

Multifunctional flexible sensor with both contact pressure sensing and internal ultrasonic detection for robotic grasping DOI

Zhange Zhang,

Zhongtan Zhang, Deqing Mei

et al.

Sensors and Actuators A Physical, Journal Year: 2025, Volume and Issue: 383, P. 116202 - 116202

Published: Jan. 6, 2025

Language: Английский

Citations

2
Wearable and Implantable Soft Robots DOI
Shukun Yin,

Dickson R. Yao,

Yu Song

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(20), P. 11585 - 11636

Published: Oct. 11, 2024

Soft robotics presents innovative solutions across different scales. The flexibility and mechanical characteristics of soft robots make them particularly appealing for wearable implantable applications. scale level invasiveness required depend on the extent human interaction. This review provides a comprehensive overview robots, including applications in rehabilitation, assistance, organ simulation, surgical tools, therapy. We discuss challenges such as complexity fabrication processes, integration responsive materials, need robust control strategies, while focusing advances actuation sensing mechanisms, techniques. Finally, we future outlook, highlighting key proposing potential solutions.

Language: Английский

Citations

14
Diving into Sweat: Advances, Challenges, and Future Directions in Wearable Sweat Sensing DOI Creative Commons

Andre Childs,

Beatriz Mayol, José A. Lasalde‐Ramírez

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(36), P. 24605 - 24616

Published: Aug. 26, 2024

Sweat analysis has advanced from diagnosing cystic fibrosis and testing for illicit drugs to noninvasive monitoring of health biomarkers. This article introduces the rapid development wearable flexible sweat sensors, highlighting key milestones various sensing strategies real-time analytes. We discuss challenges such as developing high-performance nanomaterial-based biosensors, ensuring continuous production sampling, achieving high sweat/blood correlation, biocompatibility. The potential machine learning enhance these sensors personalized healthcare is presented, enabling tracking prediction physiological changes disease onset. Leveraging advancements in electronics, nanomaterials, biosensing, data analytics, biosensors promise revolutionize management, prevention, prediction, promoting healthier lifestyles transforming medical practices globally.

Language: Английский

Citations

12
Wearable bioelectronics based on emerging nanomaterials for telehealth applications DOI Creative Commons

Yichong Ren,

Feng Zhang, Zheng Yan

et al.

Device, Journal Year: 2025, Volume and Issue: 3(1), P. 100676 - 100676

Published: Jan. 1, 2025

The bigger pictureNanomaterial-driven, soft wearable electronics hold great promise for continuous monitoring of bio-signals, efficient collection physiological data, and on-demand drug delivery. Wearable electronic devices transducing responses into electrical signals have been used in various telemedicine telediagnosis applications, such as real-time vital signs, blood pressure, body temperature, human motion. Combined with radio frequency (RF) technologies, these can transmit health data be powered wirelessly. In this review, we discuss the recent progress one- two-dimensional nanomaterials their intriguing electrical, biochemical, thermal, mechanical properties that make them suitable applications. Human sensing networks built may enable long-term, multi-physiological monitoring, thus facilitating comprehensive across metrics.SummaryNanomaterial-driven, bioelectronics are transforming by offering skin comfort, biocompatibility, capability remote signals. devices, enabled advanced zero-dimensional (0D), one-dimensional (1D), (2D) nanomaterials, achieved new levels stability reliability, allowing to perform effectively even under dynamic physical conditions. Despite promise, significant challenges remain fabrication, integration, practical deployment nanoscale materials devices. Critical include ensuring durability nanomaterial-based extended wear developing integration strategies support multifunctional modalities. Telemedicine has revolutionized healthcare enabling monitoring. within is a central factor driving breakthrough, enhance sensor sensitivity, durability, multifunctionality. These sensors leverage operating principles tailored specific intraocular pressure electrophysiological signal recording, biochemical marker tracking.Graphical abstract

Language: Английский

Citations

1
All-Fiber Volatile Organics-Perceptive Actuators DOI
Shuang Wang, Hao Liu, Yufan Zhang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Soft robots with real-time volatile organic compound (VOC) perceptivity are promising for dynamic hazard detection. However, reconciling VOC-responsive actuation an autonomous perception remains challenging. Inspired by Victoria amazonica, which blooms and closes synchronous color change under environmental stimulations, we developed a solvatophore-induced solvatochromic-piezoelectric material synthesizing solvatochromic molecule-modified palygorskite-enhanced polyvinylidene difluoride realized all-fiber actuator piezoelectric properties cooperative visual electrical of organics. Under VOCs, the exhibits bidirectional bending, obvious stable change, characteristic output, allowing identification type concentration VOC. The demonstrates large bending curvature 4.63 cm-1, ultrafast response speed up to 4.36 cm-1 s-1, excellent stability 1500 cycles without fatigue, VOC-induced output reflecting conditions. sensing, manipulation, were demonstrated as applications. VOC-triggered soft robot motion capable autonomously perceiving responding This work presents widely applicable interactive visual-electronic VOC detection strategy safety, health, protection, could also inspire exploitation high-performance responsive fiber materials.

Language: Английский

Citations

1
Highly Conductive and Stretchable Hydrogel Nanocomposite Using Whiskered Gold Nanosheets for Soft Bioelectronics DOI Open Access
Chaehong Lim,

S.-J. Lee,

Hyejeong Kang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 11, 2024

Abstract The low electrical conductivity of conductive hydrogels limits their applications as soft conductors in bioelectronics. This originates from the high water content hydrogels, which impedes facile carrier transport between fillers. study presents a highly and stretchable hydrogel nanocomposite comprising whiskered gold nanosheets. A dry network nanosheets is fabricated then incorporated into wet matrices. preserve tight interconnection despite content, providing high‐quality percolation even under stretched states. Regardless type matrix, gold‐hydrogel nanocomposites exhibit ≈520 S cm −1 stretchability ≈300% without requiring dehydration process. reaches maximum ≈3304 when density controlled. gold‐adhesive nanocomposite, can achieve conformal adhesion to moving organ surfaces, for bioelectronics demonstrations. adhesive electrode outperforms elastomer‐based electrodes vivo epicardial electrogram recording, pacing, sciatic nerve stimulation.

Language: Английский

Citations

6
Multifunctional polyurethane materials in regenerative medicine and tissue engineering DOI Creative Commons
Gao‐peng Dang,

Jun‐ting Gu,

Jing‐han Song

et al.

Cell Reports Physical Science, Journal Year: 2024, Volume and Issue: 5(7), P. 102053 - 102053

Published: June 17, 2024

Facing the problems encountered in contemporary hard and soft tissue repair, need for better solutions has never been so pressing. Traditional repair methods often fall short, leading to disappointing therapeutic outcomes complications. To address associated with engineering, polyurethane stands out because of its remarkable adaptability healing potential. This review embarks on a journey through essential properties diverse classifications polyurethane, unveiling modification strategies that amplify efficacy. Beyond process mending gaps, capability as sophisticated drug delivery system is explored offer glimpse into versatile applications. Most notably, cutting-edge advancements clinical trials bridging voids both are discussed. The present explores future bio-interface providing wave inventive poised redefine landscape regenerative medicine.

Language: Английский

Citations

5
Soft Thermoplastic Polyurethane/Silver Nanowire Membranes with Low Hysteresis for Large Strain Sensing and Joule Heating DOI

Chunfa Ye,

Tianyu Cang,

Jixiang Zhu

et al.

ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Language: Английский

Citations

4
Anisotropic hydrogel microelectrodes for intraspinal neural recordings in vivo DOI Creative Commons
Sizhe Huang,

Ruobai Xiao,

Shaoting Lin

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 28, 2025

Creating durable, motion-compliant neural interfaces is crucial for accessing dynamic tissues under in vivo conditions and linking activity with behaviors. Utilizing the self-alignment of nano-fillers a polymeric matrix repetitive tension, here, we introduce conductive carbon nanotubes high aspect ratios into semi-crystalline polyvinyl alcohol hydrogels, create electrically anisotropic percolation pathways through cyclic stretching. The resulting hydrogel fibers (diameter 187 ± 13 µm) exhibit fatigue resistance (up to 20,000 cycles at 20% strain) stretchability 64.5 7.9% low electrochemical impedance (33.20 9.27 kΩ @ 1 kHz cm length). We observe reconstructed nanofillers' axial alignment corresponding decrease along direction fabricate fiber-shaped hydrogels bioelectronic devices implant them wild-type transgenic Thy1::ChR2-EYFP mice record electromyographic signals from muscles anesthetized freely moving conditions. These effectively enable simultaneous recording electrical ventral spinal cord neurons tibialis anterior during optogenetic stimulation. Importantly, maintain functionality intraspinal electrophysiology recordings over eight months after implantation, demonstrating their durability potential long-term monitoring neurophysiological studies. essential Here, authors nanotube-enhanced creating anisotropic, fatigue-resistant electrophysiological mice.

Language: Английский

Citations

0
A linearly programmable strategy for polymer elastomer mechanics DOI
Xue Dong, Xing Su, Jin Xu

et al.

Materials Horizons, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The mechanical properties of polymer elastomer materials, such as strength and ductility, play important roles in a wide range applications, including the carrying major equipment construction infrastructure.

Language: Английский

Citations

0