Deleted Journal, Journal Year: 2025, Volume and Issue: 1(1)
Published: May 19, 2025
Language: Английский
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Nucleic acid therapeutics represent a highly promising treatment approach in modern medicine, treating diseases at the genetic level. However, these face numerous challenges practical applications, particularly regarding their stability, effectiveness, cellular uptake efficiency, and limitations delivering them specifically to target tissues. To overcome obstacles, researchers have developed various innovative delivery systems, including viral vectors, lipid nanoparticles, polymer inorganic protein carriers, exosomes, antibody oligonucleotide conjugates, DNA nanostructure-based systems. These systems enhance therapeutic efficacy of nucleic drugs by improving targeting specificity, half-life vivo. In this review, we systematically discuss different types drugs, analyze major barriers encountered delivery, summarize current research progress emerging We also highlight latest advancements application for diseases, infectious cancer, brain wound healing. This review aims provide comprehensive overview drug systems' status future directions integrating nanotechnology, biomaterials science, gene editing technologies, emphasizing transformative potential precision medicine.
Language: Английский
Citations
2
Neuroscience, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
2
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Biological carriers have emerged as significant tools to deliver radionuclides in nuclear medicine, providing a meaningful perspective for tumor imaging and treatment. Various radionuclide-labeled biological been developed meet the needs of biomedical applications. This review introduces principles radionuclide-mediated therapy selected criteria them, well comprehensive description characteristics functions representative including bacteria, cells, viruses, their derivatives, emphasizing labeled strategies combined with radionuclides. Subsequently, we in-depth introduce application treatment, behaviors vivo metastasis treatment by radionuclide therapy, plus other radiation-induced photodynamic therapy. Finally, challenges prospects are discussed improve shortcomings this innovative platform promote clinical transformation field medical imaging.
Language: Английский
Citations
1
Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123180 - 123180
Published: Feb. 13, 2025
Language: Английский
Citations
1
Nano Today, Journal Year: 2025, Volume and Issue: 63, P. 102748 - 102748
Published: April 8, 2025
Language: Английский
Citations
1
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 10, 2025
Background Cryptococcal meningitis (CM) is a significant global health issue, particularly affecting individuals with HIV. Amphotericin B (AmB) serves as the cornerstone treatment for CM; however, its clinical application restricted due to limited penetration of blood–brain barrier and associated nephrotoxicity. Objective This study investigates use exosomes derived from induced pluripotent stem cells (iPSC-Exos) carriers AmB in treating CM, aiming enhance therapeutic efficacy safety reduce toxicity. Methods Exosomes were extracted iPSC culture supernatants using ultrafiltration ultracentrifugation. Their morphology size analyzed transmission electron microscopy (TEM) nanoparticle flow cytometry (nFCM). Purity was confirmed by Western blotting markers CD9, CD63, TSG101. loaded into iPSC-Exos co-incubation method. The cytotoxicity iPSC-Exo/AmB complex evaluated on HEK 293 T RAW264.7 CCK-8 assay, while apoptosis assessed live/dead cell staining cytometry. hemolytic effects tested rabbit red blood cells. In C57BL/6 J mouse model cryptococcal infection, groups (AmB, iPSC-Exo/AmB, iPSC-Exo) administered corresponding drugs, brain samples collected analysis. minimum inhibitory concentration (MIC) conventional against Cryptococcus determined. Results exhibited reduced vitro decreased AmB-induced renal hepatic toxicity vivo . Its MIC over eight times lower than AmB, significantly reducing fungal burden lowering serum inflammatory factors. Conclusion promising strategy that enhances toxicity, offering new hope CM other refractory infections central nervous system.
Language: Английский
Citations
0
Composites Part B Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 112239 - 112239
Published: Feb. 1, 2025
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 25, 2025
Cholesterol (CHOL) is an inherently biodegradable material with multiple chiral centers, being essential component for cell membranes. Considering the close relationship between chirality and ferroelectric feature, this compound chiral-polar structure intrinsic polar material. However, ferroelectricity of CHOL crystals has never been found to date. Herein, a series cocrystals methanol (CHOL-MeOH) ethanol (CHOL-EtOH) have constructed through solvent effect. It that introduction some molecules containing hydroxyls such as can reduce acceptor···donor length thus form 1D electroactive channel further induce in CHOL. Based on density functional theory (DFT) calculation analyses represented by CHOL-EtOH, largely decreased maximum energy barrier polarization reversal ≈50% suggests electric cocrystal much easier be reoriented under external field These materials show good biocompatibility biodegradability vitro vivo evaluation. attributes make these candidates application next-generation smart implantable electronic devices. This work sheds light chemical design ferroelectrics biomaterials.
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161503 - 161503
Published: March 1, 2025
Language: Английский
Citations
0
Journal of Nanoparticle Research, Journal Year: 2025, Volume and Issue: 27(4)
Published: March 20, 2025
Language: Английский
Citations
0