Self-organized cell migration across scales – from single cell movement to tissue formation DOI Creative Commons
Jessica Stock, Andrea Pauli

Development, Journal Year: 2021, Volume and Issue: 148(7)

Published: April 1, 2021

ABSTRACT Self-organization is a key feature of many biological and developmental processes, including cell migration. Although migration has traditionally been viewed as response to extrinsic signals, advances within the past two decades have highlighted importance intrinsic self-organizing properties direct on multiple scales. In this Review, we will explore mechanisms that lay foundation for both single collective Based in vitro vivo examples, discuss theoretical concepts underlie persistent cells absence directional guidance cues, formation an autonomous drives coordinated Finally, highlight general implications principles guiding medical research.

Language: Английский

Tribochemistry, Mechanical Alloying, Mechanochemistry: What is in a Name? DOI Creative Commons
Adam A. L. Michalchuk∞, E.V. Boldyreva, Ana M. Belenguer

et al.

Frontiers in Chemistry, Journal Year: 2021, Volume and Issue: 9

Published: May 26, 2021

Over the decades, application of mechanical force to influence chemical reactions has been called by various names: mechanochemistry, tribochemistry, alloying, name but a few. The evolution these terms largely mirrored understanding field. But what is meant terms, why have they evolved, and does it really matter how process called? Which parameters should be defined describe unambiguously experimental conditions such that others can reproduce results, or allow meaningful comparison between processes explored under different conditions? Can information on encoded in clear, concise, self-explanatory way? We address questions this Opinion contribution, which we hope will spark timely constructive discussion across international mechanochemical community.

Language: Английский

Citations

161
Nonreciprocal Pattern Formation of Conserved Fields DOI Creative Commons
Fridtjof Brauns, M. Cristina Marchetti

Physical Review X, Journal Year: 2024, Volume and Issue: 14(2)

Published: April 19, 2024

In recent years, nonreciprocally coupled systems have received growing attention. Previous work has shown that the interplay of nonreciprocal coupling and Goldstone modes can drive emergence temporal order such as traveling waves. We show these phenomena are generically found in a broad class pattern-forming systems, including mass-conserving reaction-diffusion viscoelastic active gels. All share characteristic dispersion relation acquires nonzero imaginary part at edge band unstable exhibit regime propagating structures (traveling wave bands or droplets). models for be mapped to common “normal form” seen spatially extended generalization FitzHugh-Nagumo model, providing unifying dynamical-systems perspective. minimal Cahn-Hilliard equations surprisingly rich set behaviors, interrupted coarsening waves without selection preferred wavelength transversal undulations fronts two dimensions. their speed precisely predicted from interfaces far away homogeneous steady state. Our work, thus, generalizes previously studied phase transitions shows relevant collective excitations governing dynamical patterns conserved fields. Published by American Physical Society 2024

Language: Английский

Citations

18
Infrared nanosensors of piconewton to micronewton forces DOI
Natalie Fardian‐Melamed, Artiom Skripka,

Benedikt Ursprung

et al.

Nature, Journal Year: 2025, Volume and Issue: 637(8044), P. 70 - 75

Published: Jan. 1, 2025

Language: Английский

Citations

8
ERK activation waves coordinate mechanical cell competition leading to collective elimination via extrusion of bacterially infected cells DOI Creative Commons
Lara Hundsdorfer, Marie Muenkel, Raúl Aparicio-Yuste

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(1), P. 115193 - 115193

Published: Jan. 1, 2025

Epithelial cells respond to infection with the intracellular bacterial pathogen Listeria monocytogenes by altering their mechanics promote collective infected cell extrusion (CICE) and limit spread across monolayers. However, underlying biochemical pathways remain elusive. Here, using in vitro (epithelial monolayers) vivo (zebrafish larvae) models of L. or Shigella flexneri, we explored role extracellular-signal-regulated kinase (ERK) activity waves coordinating mechanical battle between surrounder uninfected that leads CICE. We discovered when ERK are suppressed, fail exhibit alterations shape kinematics associated CICE behave more like quiescent In particular, surrounding foci unable polarize, reinforce monolayer stresses, Our findings reveal crosstalk is key elimination large domains cells.

Language: Английский

Citations

2
Mechanochemical Principles of Spatial and Temporal Patterns in Cells and Tissues DOI Open Access
Anaïs Bailles, Emily W. Gehrels, Thomas Lecuit

et al.

Annual Review of Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 38(1), P. 321 - 347

Published: May 14, 2022

Patterns are ubiquitous in living systems and underlie the dynamic organization of cells, tissues, embryos. Mathematical frameworks have been devised to account for self-organization biological patterns, most famously Turing framework. can be defined space, example, form stripes; time, such as during oscillations; or both, traveling waves. The formation these patterns different origins: purely chemical, mechanical, a combination two. Beyond variety molecular implementations we emphasize unitary principles associated with them, across scales space within general mechanochemical We illustrate where mechanisms pattern arise from cellular tissue scales, an emphasis on morphogenesis. Our goal is convey picture that draws attention rather than solely specific mechanisms.

Language: Английский

Citations

58
Spatiotemporal control of ERK pulse frequency coordinates fate decisions during mammary acinar morphogenesis DOI Creative Commons
Pascal Ender, Paolo Armando Gagliardi, Maciej Dobrzyński

et al.

Developmental Cell, Journal Year: 2022, Volume and Issue: 57(18), P. 2153 - 2167.e6

Published: Sept. 1, 2022

Language: Английский

Citations

52
ERK-mediated curvature feedback regulates branching morphogenesis in lung epithelial tissue DOI Creative Commons
Tsuyoshi Hirashima, Michiyuki Matsuda

Current Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Intricate branching patterns emerge in internal organs due to the recurrent occurrence of simple deformations epithelial tissues. During murine lung development, cells distal tips single tube require fibroblast growth factor (FGF) signals emanating from their surrounding mesenchyme form repetitive tip bifurcations. However, it remains unknown how employ FGF signaling convert behaviors achieve recursive processes. Here, we show a mechano-chemical regulatory system underlying morphogenesis, orchestrated by extracellular signal-regulated kinase (ERK) as downstream driver signaling. We found that tissue-scale curvature regulated ERK activity epithelium using two-photon live cell imaging and mechanical perturbations. activation occurs specifically tissues exhibiting positive curvature, regardless whether change was attributable morphogenesis or Moreover, accelerates actin polymerization preferentially at apical side cells, mechanically contributing extension membrane, culminating reduction tissue curvature. These results indicate existence negative feedback loop between transcends spatial scales. Our mathematical model confirms this mechanism is sufficient generate Taken together, propose orchestrates pivotal self-organized patterning

Language: Английский

Citations

15
Learning dynamical models of single and collective cell migration: a review DOI Creative Commons
David B. Brückner,

Chase P. Broedersz

Reports on Progress in Physics, Journal Year: 2024, Volume and Issue: 87(5), P. 056601 - 056601

Published: March 22, 2024

Single and collective cell migration are fundamental processes critical for physiological phenomena ranging from embryonic development immune response to wound healing cancer metastasis. To understand a physical perspective, broad variety of models the underlying mechanisms that govern motility have been developed. A key challenge in such is how connect them experimental observations, which often exhibit complex stochastic behaviours. In this review, we discuss recent advances data-driven theoretical approaches directly with data infer dynamical migration. Leveraging nanofabrication, image analysis, tracking technology, studies now provide unprecedented large datasets on cellular dynamics. parallel, efforts directed towards integrating into single tissue scale aim conceptualising emergent behaviour cells. We first review inference problem has addressed both freely migrating confined Next, why these dynamics typically take form underdamped equations motion, can be inferred data. then applications machine learning heterogeneity behaviour, subcellular degrees freedom, multicellular systems. Across applications, emphasise methods integrated active matter cells, help reveal molecular control behaviour. Together, promising avenue building data, providing conceptual links between different length-scales description.

Language: Английский

Citations

12
The role of fibronectin in mediating cell migration DOI

Jessica H. Longstreth,

Karin Wang

AJP Cell Physiology, Journal Year: 2024, Volume and Issue: 326(4), P. C1212 - C1225

Published: Feb. 19, 2024

Fibronectin (FN) is a major extracellular matrix (ECM) protein involved in wide range of physiological processes, including cell migration. These FN-mediated migration events are essential to processes such as wound repair, cancer metastasis, and vertebrate development. This review synthesizes mainly current literature provide an overview the mechanoregulatory role Background on FN structure mechanotransduction provided. Cell concepts introduced, general mechanism classification types. Then, that directly affect explored. Finally, focus tissue repair presented, these topics represent large amount research.

Language: Английский

Citations

11
Information transmission in a cell monolayer: A numerical study DOI Creative Commons
Paweł Nałęcz‐Jawecki,

Przemysław Szyc,

Frederic Grabowski

et al.

PLoS Computational Biology, Journal Year: 2025, Volume and Issue: 21(2), P. e1012846 - e1012846

Published: Feb. 21, 2025

Motivated by the spatiotemporal waves of MAPK/ERK activity, crucial for long-range communication in regenerating tissues, we investigated stochastic homoclinic fronts propagating through channels formed directly interacting cells. We evaluated efficiency these examining rate information transmission. Our study identified phenomena that reduce this rate: front propagation failure, new spawning, and variability velocity. found a trade-off between frequencies failures spawning determines optimal channel width (which geometrically length). The frequency initiating is determined input (higher with more frequent initiation) fidelity transmission (lower initiation). analysis provides insight into relative timescales intra- intercellular processes necessary successful wave propagation.

Language: Английский

Citations

1