The evolving metabolic landscape of chromatin biology and epigenetics

Nature Reviews Genetics, Journal Year: 2020, Volume and Issue: 21(12), P. 737 - 753

Published: Sept. 9, 2020

Language: Английский

---

Metabolism of Amino Acids in Cancer

Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 8

Published: Jan. 12, 2021

Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The uptake and metabolism amino acids are aberrantly upregulated in many cancers that display addiction to particular acids. Amino facilitate the survival proliferation cancer cells under genotoxic, oxidative, nutritional stress. Thus, targeting acid is becoming potential therapeutic strategy for patients. In this review, we will systematically summarize recent progress malignancy discuss their interconnection with mammalian target rapamycin complex 1 (mTORC1) signaling, epigenetic modification, tumor growth immunity, ferroptosis. Finally, highlight applications.

Language: Английский

---

Understanding mechanisms of antioxidant action in health and disease

Nature Reviews Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 25(1), P. 13 - 33

Published: Sept. 15, 2023

Language: Английский

---

Amino acid metabolism in health and disease

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Sept. 13, 2023

Abstract Amino acids are the building blocks of protein synthesis. They structural elements and energy sources cells necessary for normal cell growth, differentiation function. acid metabolism disorders have been linked with a number pathological conditions, including metabolic diseases, cardiovascular immune cancer. In case tumors, alterations in amino can be used not only as clinical indicators cancer progression but also therapeutic strategies. Since growth development tumors depend on intake foreign acids, more studies targeted tumor-related to selectively kill tumor cells. Furthermore, immune-related confirmed that regulates function effector T regulatory cells, affecting Therefore, studying associated disease identifying targets pathways may helpful treatment. This article mainly focuses research tumor-oriented reviews progress diseases related metabolism, order provide theoretical basis therapy metabolism.

Language: Английский

---

Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy

Molecular Cell, Journal Year: 2020, Volume and Issue: 80(3), P. 384 - 395

Published: Sept. 29, 2020

Language: Английский

---

Amino Acid Depletion Therapies: Starving Cancer Cells to Death

Trends in Endocrinology and Metabolism, Journal Year: 2021, Volume and Issue: 32(6), P. 367 - 381

Published: March 29, 2021

Targeting tumor cell metabolism is an attractive form of therapy, as it may enhance treatment response in therapy resistant cancers well mitigate treatment-related toxicities by reducing the need for genotoxic agents. To meet their increased demand biomass accumulation and energy production to maintain redox homeostasis, cells undergo profound changes metabolism. In addition diversion glucose metabolism, this achieved upregulation amino acid Interfering with availability can be selectively lethal has proven a cancer specific Achilles' heel. Here we review biology behind such dependencies discuss how these vulnerabilities exploited improve therapies.

Language: Английский

---

Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy

Journal of Hematology & Oncology, Journal Year: 2023, Volume and Issue: 16(1)

Published: June 5, 2023

Abstract Amino acids are basic nutrients for immune cells during organ development, tissue homeostasis, and the response. Regarding metabolic reprogramming in tumor microenvironment, dysregulation of amino acid consumption is an important underlying mechanism leading to impaired anti-tumor immunity. Emerging studies have revealed that altered metabolism tightly linked outgrowth, metastasis, therapeutic resistance through governing fate various cells. During these processes, concentration free acids, their membrane bound transporters, key enzymes, sensors such as mTOR GCN2 play critical roles controlling cell differentiation function. As such, anti-cancer responses could be enhanced by supplement specific essential or targeting enzymes sensors, thereby developing novel adjuvant modalities. To further dissect regulation immunity, this review summarizes regulatory mechanisms effects on phenotypes functions tumor-infiltrating propose approaches exploited rewire enhance cancer immunotherapy.

Language: Английский

---

Methionine Restriction and Cancer Biology

Nutrients, Journal Year: 2020, Volume and Issue: 12(3), P. 684 - 684

Published: March 3, 2020

The essential amino acid, methionine, is important for cancer cell growth and metabolism. A growing body of evidence indicates that methionine restriction inhibits may enhance the efficacy chemotherapeutic agents. This review summarizes mechanism action on hallmarks in vitro vivo. highlights role glutathione formation, polyamine synthesis, methyl group donation as mediators effects biology. translational potential use a personalized nutritional approach treatment patients with also discussed.

Language: Английский

---

Breaking the Intracellular Redox Balance with Diselenium Nanoparticles for Maximizing Chemotherapy Efficacy on Patient-Derived Xenograft Models

ACS Nano, Journal Year: 2020, Volume and Issue: 14(12), P. 16984 - 16996

Published: Dec. 7, 2020

Excessive oxidative stress in cancer cells can induce cell death. Anticancer activity and drug resistance of chemotherapy are closely related to the redox state tumor cells. Herein, five lipophilic Pt(IV) prodrugs were synthesized on basis most widely used anticancer cisplatin, whose efficacy intracellular state. Subsequently, a series cisplatin-sensitive drug-resistant lines as well three patient-derived primary ovarian have been selected screen those prodrugs. To verify if disruption balance be combined with these prodrugs, we then polymer diselenium bond main chain for encapsulating effective prodrug form nanoparticles (NP(Se)s). NP(Se)s efficiently break via simultaneously depleting GSH augmenting ROS, thereby achieving synergistic effect cisplatin. In addition, genome-wide analysis RNA-seq was employed provide comprehensive understanding changes transcriptome alterations redox-related pathways treated Thereafter, xenograft models hepatic carcinoma (PDXHCC) multidrug-resistant lung (PDXMDR) established evaluate therapeutic NP(Se)s, significant antitumor achieved both NP(Se)s. Overall, this study provides promising strategy maximizing platinum-based therapy.

Language: Английский

---

The diversity and breadth of cancer cell fatty acid metabolism

Cancer & Metabolism, Journal Year: 2021, Volume and Issue: 9(1)

Published: Jan. 7, 2021

Tumor cellular metabolism exhibits distinguishing features that collectively enhance biomass synthesis while maintaining redox balance and homeostasis. These attributes reflect the complex interactions between cell-intrinsic factors such as genomic-transcriptomic regulation cell-extrinsic influences, including growth factor nutrient availability. Alongside glucose amino acid metabolism, fatty supports tumorigenesis disease progression through a range of processes membrane biosynthesis, energy storage production, generation signaling intermediates. Here, we highlight complexity in cancer, various inputs outputs intracellular free pool, numerous ways these pathways influence behavior.

Language: Английский

---