Glutathione-Depleting Nanomedicines for Synergistic Cancer Therapy

ACS Nano, Journal Year: 2021, Volume and Issue: 15(5), P. 8039 - 8068

Published: May 11, 2021

Cancer cells frequently exhibit resistance to various molecular and nanoscale drugs, which inevitably affects the drugs' therapeutic outcomes. Overexpression of glutathione (GSH) has been observed in many cancer cells, solid evidence corroborated resulting tumor a variety anticancer therapies, suggesting that this biochemical characteristic can be developed as potential target for treatments. The single treatment GSH-depleting agents potentiate responses different cell death stimuli; therefore, an adjunctive strategy, GSH depletion is usually combined with mainstream therapies enhancing Propelled by rapid development nanotechnology, readily constructed into nanomedicines, have shown steep rise over past decade. Here, we review common nanomedicines widely applied synergistic treatments recent years. Some current challenges future perspectives depletion-based are also presented. With understanding structure–property relationship action mechanisms these biomaterials, hope nanotechnology will further realize more effective disease even achieve successful clinical translations.

Language: Английский

---

Stimuli‐Responsive Nanoparticles for Controlled Drug Delivery in Synergistic Cancer Immunotherapy

Advanced Science, Journal Year: 2021, Volume and Issue: 9(5)

Published: Dec. 19, 2021

Cancer immunotherapy has achieved promising clinical progress over the recent years for its potential to treat metastatic tumors and inhibit their recurrences effectively. However, low patient response rates dose-limiting toxicity remain as major dilemmas immunotherapy. Stimuli-responsive nanoparticles (srNPs) combined with offer possibility amplify anti-tumor immune responses, where weak acidity, high concentration of glutathione, overexpressions enzymes, reactive oxygen species, external stimuli in act triggers controlled drug release. This review highlights design srNPs based on tumor microenvironment and/or combine different drugs, especially immunoregulatory agents, which eventually realize synergistic malignant primary or acquire a long-term memory prevent recurrence. The authors hope that this can provide theoretical guidance construction transformation smart delivery cancer

Language: Английский

---

Photo‐Reduction with NIR Light of Nucleus‐Targeting Pt^IVNanoparticles for Combined Tumor‐Targeted Chemotherapy and Photodynamic Immunotherapy

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(20)

Published: Feb. 25, 2022

Abstract The development of Pt IV prodrugs which are selectively reduced within cancerous cells into their II therapeutically active species has received increasing attention the last decade. Despite recent research progress, majority investigated compounds excited using ultraviolet or blue light. As light penetration depth is low at these wavelengths, treatment deep‐seated large tumors limited. To overcome this limitation, herein, example ‐functionalized nanoparticles that could be NIR region 808 nm reported. polymer backbone can self‐assemble was functionalized with complexes for chemotherapy, photosensitizers photodynamic immunotherapy, and nucleus/cancer‐targeting peptides. Upon irradiation, center to axially coordinated ligands released, presenting a multimodal treatment. While accumulating in tumorous tissue, demonstrated ability eradicate triple‐negative breast cancer tumor inside mouse model.

Language: Английский

---

Biodegradable Polymer with Effective Near‐Infrared‐II Absorption as a Photothermal Agent for Deep Tumor Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(4)

Published: Oct. 25, 2021

Photothermal therapy holds great promise for cancer treatment due to its effective tumor ablation and minimal invasiveness. Herein a new class of biodegradable photothermal agents with adsorption in both near-infrared-I (NIR-I) NIR-II windows is reported deep therapy. As demonstrated deep-seated ovarian model, using 1064 nm irradiation effectively inhibits progression prolongs survival spans. This work provides design toward more tumors.

Language: Английский

---

Overcoming Cancer Multi-drug Resistance (MDR): Reasons, mechanisms, nanotherapeutic solutions, and challenges

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114643 - 114643

Published: April 7, 2023

Multi-drug resistance (MDR) in cancer cells, either intrinsic or acquired through various mechanisms, significantly hinders the therapeutic efficacy of drugs. Typically, reduced performance drugs is predominantly due to inherent over expression ATP-binding cassette (ABC) transporter proteins on cell membrane, resulting deprived uptake drugs, augmenting drug detoxification, and DNA repair. In addition physiological abnormalities extensive blood flow, MDR phenotypes exhibit improved apoptotic threshold efflux efficiency. These severe consequences have substantially directed researchers fabrication advanced strategies, such as co-delivery along with generations inhibitors, augmented dosage regimens frequency administration, well combinatorial treatment options, among others. this review, we emphasize different reasons mechanisms responsible for cancer, including but not limited known mediated by permeability glycoprotein (P-gp) other pumps, uptake, altered repair, targets, Further, an emphasis specific cancers that share pathogenesis executing effluxed common provided. Then, aspects related nanomaterials-based supramolecular programmable designs (organic- inorganic-based materials), physical approaches (light- ultrasound-based therapies), are discussed, highlighting unsolved issues future advancements. Finally, summarize review interesting perspectives trends, exploring further opportunities overcome MDR.

Language: Английский

---

Theranostic Fluorescent Probes

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(5), P. 2699 - 2804

Published: Feb. 29, 2024

The ability to gain spatiotemporal information, and in some cases achieve control, the context of drug delivery makes theranostic fluorescent probes an attractive intensely investigated research topic. This interest is reflected steep rise publications on topic that have appeared over past decade. Theranostic probes, their various incarnations, generally comprise a fluorophore linked masked drug, which released as result certain stimuli, with both intrinsic extrinsic stimuli being reported. release then signaled by emergence signal. Importantly, use appropriate fluorophores has enabled not only this emerging fluorescence marker for but also provided modalities useful photodynamic, photothermal, sonodynamic therapeutic applications. In review we highlight recent work particular focus are activated tumor microenvironments. We summarize efforts develop other applications, such neurodegenerative diseases antibacterials. celebrates diversity designs reported date, from discrete small-molecule systems nanomaterials. Our aim provide insights into potential clinical impact still-emerging direction.

Language: Английский

---

Stimuli-Responsive Polymer-Based Nanosystems for Cancer Theranostics

ACS Nano, Journal Year: 2023, Volume and Issue: 17(23), P. 23223 - 23261

Published: Dec. 2, 2023

Stimuli-responsive polymers can respond to internal stimuli, such as reactive oxygen species (ROS), glutathione (GSH), and pH, biological enzymes, external lasers ultrasound, etc., by changing their hydrophobicity/hydrophilicity, degradability, ionizability, thus have been widely used in biomedical applications. Due the characteristics of tumor microenvironment (TME), stimuli-responsive that cater specifically TME extensively prepare smart nanovehicles for targeted delivery therapeutic diagnostic agents tissues. Compared conventional drug nanosystems, TME-responsive nanosystems many advantages, high sensitivity, broad applicability among different tumors, functional versatility, improved biosafety. In recent years, a great deal research has devoted engineering efficient polymeric significant improvement made both cancer diagnosis therapy. this review, we summarize some advances involving use polymer nanocarriers delivery, imaging, therapy, theranostics. Various chemical stimuli will be described context nanosystems. Accordingly, groups responsible responsiveness strategies incorporate these into discussed detail. With on topic expending at fast pace, innovative concepts, sequential cascade release, NIR-II multifunctional formulations, emerged popular enhanced performance, which also included here with up-to-date illustrations. We hope review offer valuable insights selection optimization help accelerate future applications treatment.

Language: Английский

---

A Systematic Strategy of Combinational Blow for Overcoming Cascade Drug Resistance via NIR‐Light‐Triggered Hyperthermia

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(20)

Published: April 8, 2021

Abstract A systematic combination strategy is proposed for overcoming cisplatin resistance using near‐infrared (NIR)‐light‐triggered hyperthermia. new photothermal polymer DAP‐F complexed with a reduction‐sensitive amphiphilic P1 to form F‐NPs effect. Subsequently, build the final nanosystem F–Pt‐NPs, are combined Pt‐NPs, which obtained by encapsulating Pt(IV) prodrug . Mild hyperthermia (43 °C), generated from F–Pt‐NPs induced an 808 nm NIR laser, have various effects such as: i) enhancing cellular membrane permeability promote uptake of drugs; ii) activating accelerating glutathione consumption; iii) increasing Pt‐DNA adducts formation and possibly portion irreparable interstrand crosslinks, thereby inhibiting repair DNA. In vitro, it found that even on cisplatin‐resistant A549DDP cells, IC 50 °C) only 7.0 × 10 −6 m Pt mL −1 vivo, patient‐derived xenograft model multidrug resistant lung cancer, efficacy treatment group shows tumor inhibition rate 94%. Taken together, here, important perspective resolving cascade drug assistance mild triggered light presented, can be great significance clinic translation.

Language: Английский

---

Triple-synergistic MOF-nanozyme for efficient antibacterial treatment

Bioactive Materials, Journal Year: 2022, Volume and Issue: 17, P. 289 - 299

Published: Feb. 1, 2022

The abuse of antibiotics makes bacterial infection an increasingly serious global health threat. Reactive oxygen species (ROS) are the ideal alternative antibacterial approach for quick and effective sterilization. Although various strategies based on ROS have been developed, many them still limited by insufficient efficiency. Here, we developed acid-enhanced dual-modal strategy zeolitic imidazolate frameworks-8 (ZIF8) -derived nanozyme. ZIF8, which can release Zn

Language: Английский

---

MOF-derived CuS@Cu-MOF nanocomposites for synergistic photothermal-chemodynamic-chemo therapy

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 441, P. 135964 - 135964

Published: March 23, 2022

Language: Английский

---