Handbook of Religion and Health

Oxford University Press eBooks, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 23, 2023

Abstract The 2001 (first) edition of this Handbook was a comprehensive review history, research, and discussions on religion health through the year 2000. Appendix listed 1,200 separate quantitative studies each rated in quality 0–10 scale, followed by about 2,000 references an extensive index for rapid topic identification. 2012 (second) systematically updated research from 2000 to 2010, with number then reaching thousands. This 2023 (third) is most scientifically rigorous date, covering best published 2021 emphasis prospective randomized controlled trials. Beginning Foreword Dr. Howard K. Koh, former US Assistant Secretary Health Department Human Services, nearly 600,000-word volume examines almost every aspect health, reviewing past more recent relationship between outcomes. Furthermore, all its 34 chapters conclude clinical community applications, making text relevant both healthcare professionals (physicians, nurses, social workers, rehabilitation therapists, counselors, psychologists, sociologists, etc.) clergy (community clergy, chaplains, pastoral etc.). book’s focuses studies, describing study single line, allowing researchers quickly locate existing research. It should not be surprising that two decades has been cited health.

Language: Английский

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Meta-hallmarks of aging and cancer

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(1), P. 12 - 35

Published: Jan. 1, 2023

Language: Английский

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Helicobacter pylori , Homologous-Recombination Genes, and Gastric Cancer

New England Journal of Medicine, Journal Year: 2023, Volume and Issue: 388(13), P. 1181 - 1190

Published: March 29, 2023

Helicobacter pylori infection is a well-known risk factor for gastric cancer. However, the contribution of germline pathogenic variants in cancer-predisposing genes and their effect, when combined with H. infection, on cancer has not been widely evaluated.We evaluated association between 27 sample 10,426 patients 38,153 controls from BioBank Japan. We also assessed effect status calculated cumulative 1433 5997 Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC).Germline nine (APC, ATM, BRCA1, BRCA2, CDH1, MLH1, MSH2, MSH6, PALB2) were associated found an interaction homologous-recombination respect to HERPACC (relative excess due interaction, 16.01; 95% confidence interval [CI], 2.22 29.81; P = 0.02). At 85 years age, persons variant had higher than noncarriers infected (45.5% [95% CI, 20.7 62.6] vs. 14.4% 12.2 16.6]).H. modified genes. (Funded by Japan Agency Medical Development others.).

Language: Английский

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Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial

Nature Medicine, Journal Year: 2021, Volume and Issue: 27(11), P. 1910 - 1920

Published: Nov. 1, 2021

Abstract Mesothelioma is a rare and fatal cancer with limited therapeutic options until the recent approval of combination immune checkpoint blockade. Here we report results phase 2 PrE0505 trial ( NCT02899195 ) anti-PD-L1 antibody durvalumab plus platinum-pemetrexed chemotherapy for 55 patients previously untreated, unresectable pleural mesothelioma. The primary endpoint was overall survival compared to historical control cisplatin pemetrexed chemotherapy; secondary exploratory endpoints included safety, progression-free biomarkers response. met pre-specified endpoint, reaching median 20.4 months versus 12.1 control. Treatment-emergent adverse events were consistent known side effects chemotherapy, all due immunotherapy grade or lower. Integrated genomic cell repertoire analyses revealed that higher immunogenic mutation burden coupled more diverse T linked favorable clinical outcome. Structural genome-wide showed degree instability in responding tumors epithelioid histology. Patients germline alterations predisposing genes, especially those involved DNA repair, likely achieve long-term survival. Our findings indicate concurrent platinum-based has promising activity responses are driven by complex background malignant

Language: Английский

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Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy

Proceedings of the National Academy of Sciences, Journal Year: 2020, Volume and Issue: 117(41), P. 25543 - 25552

Published: Sept. 30, 2020

Significance Millions of people have been exposed to asbestos and are at increased risk developing mesothelioma, an aggressive malignancy resistant current therapies. Here, we elucidate critical steps in carcinogenesis: induces the release high mobility group box 1 that triggers autophagy. Autophagy activation constitutes a key biological process allows some mesothelial cells survive cytotoxicity consequently increases fraction DNA-damaged human susceptible malignant transformation. We found inhibition autophagy using either chloroquine or antidepressant drug desmethylclomipramine asbestos-induced cell death reduced asbestos-mediated Our data suggest these Food Drug Administration-approved drugs might be repurposed protect high-risk asbestos-exposed individuals from mesothelioma.

Language: Английский

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Molecular Pathogenesis of Colorectal Cancer with an Emphasis on Recent Advances in Biomarkers, as Well as Nanotechnology-Based Diagnostic and Therapeutic Approaches

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(1), P. 169 - 169

Published: Jan. 4, 2022

Colorectal cancer (CRC) is a serious disease that affects millions of people throughout the world, despite considerable advances in therapy. The formation colorectal adenomas and invasive adenocarcinomas consequence succession genetic epigenetic changes normal colonic epithelium. Genetic processes associated with onset, development, metastasis sporadic CRC have been studied depth, resulting identifying biomarkers might be used to predict behaviour prognosis beyond staging influence therapeutic options. A novel biomarker, or group biomarkers, must discovered order build an accurate clinically useful test may as alternative conventional methods for early detection identify prospective new intervention targets. To minimise mortality burden cancer, screening higher accuracy nano-based diagnostic precision are needed. Cytotoxic medication has negative side effects restricted by resistance. One most promising treatment techniques use carrier system delivery mechanism. deliver cytotoxic medicines, targeted nanoparticles take advantage differently expressed molecules on surface cells. different compounds ligands interact cells, enabling efficient antitumor medicines. Formulations based aid diagnosis help overcome limitations traditional treatments, including low water solubility, nonspecific biodistribution, bioavailability. This article addresses about molecular pathogenesis highlights biomarkers. It also provides conceptual knowledge nanotechnology-based approaches malignant cancer.

Language: Английский

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Medical and Surgical Care of Patients With Mesothelioma and Their Relatives Carrying Germline BAP1 Mutations

Journal of Thoracic Oncology, Journal Year: 2022, Volume and Issue: 17(7), P. 873 - 889

Published: April 21, 2022

The most common malignancies that develop in carriers of BAP1 germline mutations include diffuse malignant mesothelioma, uveal and cutaneous melanoma, renal cell carcinoma, less frequently, breast cancer, several types skin carcinomas, other tumor types. Mesotheliomas these patients are significantly aggressive, require a multidisciplinary approach involves genetic counseling, medical genetics, pathology, surgical, medical, radiation oncology expertise. Some have asymptomatic mesothelioma can be followed by close clinical observation without apparent adverse outcomes: they may survive many years therapy. Others grow aggressively but very often respond to Detecting has, therefore, substantial social, economic impact. Close monitoring their relatives is expected result prolonged life expectancy, improved quality life, being cost-effective. co-authors this paper those who published the vast majority cases occurring carrying inactivating studied families affected cancer syndrome for years. This reports our experience. It intended source information all physicians care mutations. We discuss presentation, diagnostic treatment challenges, recommendations how best family members, including potential psychosocial

Language: Английский

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Epigenetic targeted therapy of stabilized BAP1 in ASXL1 gain-of-function mutated leukemia

Nature Cancer, Journal Year: 2021, Volume and Issue: 2(5), P. 515 - 526

Published: May 25, 2021

Language: Английский

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A new source of representative secondary PET nanoplastics. Obtention, characterization, and hazard evaluation

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 439, P. 129593 - 129593

Published: July 14, 2022

Micro and nanoplastics (MNPLs) are emergent environmental pollutants requiring urgent information on their potential risks to human health. One of the problems associated with evaluation undesirable effects is lack representative samples, matching those resulting from degradation plastic wastes. To such end, we propose an easy method obtain polyethylene terephthalate water bottles (PET-NPLs) but, in principle, applicable any other goods sources. An extensive characterization indicates that proposed process produces uniform samples PET-NPLs around 100 nm, as determined by using AF4 multi-angle dynamic light scattering methodologies. important point be highlighted avoid metal contamination methods blades/burrs for milling, trituration, or sanding, use diamond burrs produce metal-free samples. visualize toxicological profile produced have evaluated ability internalized cells, cytotoxicity, induce oxidative stress, DNA damage. In this preliminary approach, detected cellular uptake, but without induction significant biological effects. Thus, no relevant increases toxicity, reactive oxygen species (ROS) induction, damage -as comet assay- been observed. The study, will generate data discussion about health MNPLs exposures.

Language: Английский

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Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions

Molecular Cell, Journal Year: 2022, Volume and Issue: 83(2), P. 167 - 185.e9

Published: Dec. 27, 2022

Language: Английский

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