Abdominal Radiology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 8, 2025
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(6), P. 3375 - 3375
Published: March 21, 2022
Colorectal cancer (CRC) is the second most common cause of death in world. Both modifiable and nonmodifiable risk factors play a significant role pathogenesis this tumor. The diagnosis usually made late due to limitations screening tests; therefore, scientists are looking for new diagnostic tools such as gene or miRNA expression different proteins' concentrations, e.g., vascular endothelial growth factor (VEGF) family members. VEGF (VEGF-A, VEGF-B, VEGF-C, VEGF-D PlGF) plays key processes blood vessel formation embryonic development well pathological angiogenesis lymphangiogenesis, which allow tumor grow exponentially. Blockage VEGF-related pathways seems be valid therapeutic target. It was suggested recent studies, that besides already used drugs, bevacizumab, there other agents with potential usefulness anticancer activity miRNAs, TMEA, granzyme K, baicalein arginine. Moreover, proteins were assessed induce anti-apoptotic BCL-2 BAX. Therefore, investigations concerning members, not only but also therapy CRC, order fully elucidate their carcinogenesis, extremely important.
Language: Английский
Citations
76
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: July 19, 2024
Abstract Colorectal cancer, the third most prevalent cancer globally, contributes significantly to mortality rates, with over 1.9 million reported cases and nearly 935,000 fatalities annually. Surgical resection is a primary approach for localized colorectal tumors, adjunct therapies like chemotherapy, radiotherapy, targeted/immunotherapy considered depending on tumor stage. However, despite preferences targeted immunotherapy post-surgery, chemotherapy remains commonly chosen due its lower cost high cancer-killing efficiency. Yet, faces issues such as resistance severe side effects. Nanotechnology has emerged in therapy by alleviating drawbacks of current treatment approaches. In past few decades, inorganic nanoparticles have shown promise combating offering advantages conventional chemotherapy. Compared organic nanoparticles, exhibit properties photosensitivity, conductivity, magnetic allure, thermal proficiency, allowing them function both drug carriers therapeutic agents. Derived primarily from carbon, silica, metals, metal oxides, they offer superior drug-loading capacity, heightened quantum yield, participation advanced photothermal photodynamic therapies. This review provides brief overview pathophysiology pivotal role therapy, delivery. Additionally, it discusses numerous based recent literature. Graphical abstract
Language: Английский
Citations
24
Intelligent Pharmacy, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Citations
18
Molecules, Journal Year: 2022, Volume and Issue: 27(17), P. 5369 - 5369
Published: Aug. 23, 2022
Today, cancer treatment is an important issue in the medical world due to challenges and side effects of ongoing procedures. Current methods can be replaced with targeted nano-drug delivery systems overcome such effects. In present work, intelligent nano-system consisting Chitosan (Ch)/Gamma alumina (γAl)/Fe3O4 5-Fluorouracil (5-FU) was synthesized designed for first time order influence Michigan Cancer Foundation-7 (MCF-7) cell line breast cancer. Physico-chemical characterization nanocarriers carried out using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), vibrating sample magnetometry (VSM), dynamic light scattering (DLS), scanning electron microscopy (SEM). SEM analysis revealed smooth homogeneous spherical nanoparticles. The high stability nanoparticles their narrow size distribution confirmed by DLS. results loading study demonstrated that these nano-systems cause controlled, stable, pH-sensitive release cancerous environments inactive targeting mechanism. Finally, MTT flow cytometry tests indicated this increased rate apoptosis induction on masses could effective alternative current treatments.
Language: Английский
Citations
60
Applied Sciences, Journal Year: 2022, Volume and Issue: 12(19), P. 9479 - 9479
Published: Sept. 21, 2022
The increase in cancer cases is undoubtedly affecting the development of new therapeutic approaches. Polymeric nanoparticles are great interest. Due to their relatively small size, possibility incorporating into them medicinal substances and ease with which physicochemical properties may be manipulated, they being used as anticancer drug delivery systems. aim this review focus on use nanoscale polymeric particles treatment colorectal cancer, breast ovarian glioblastoma multiforme, consider potential gene therapy. According several reports, polymer carriers promising solid tumors. With application, it possible precisely deliver tumor structure, overcome blood–brain barrier case brain tumors, reduce side effects agents normal cells achieve a effect lower dose. Additionally, number reports indicate that can also combination other methods treatment, mainly radiotherapy.
Language: Английский
Citations
52
Cancers, Journal Year: 2023, Volume and Issue: 15(2), P. 383 - 383
Published: Jan. 6, 2023
Colorectal cancer is the third most common worldwide. Despite recent advances in treatment of this pathology, which include a personalized approach using radio- and chemotherapies combination with advanced surgical techniques, it imperative to enhance performance these treatments decrease their detrimental side effects on patients’ health. Nanomedicine likely pathway towards solving challenge by enhancing both therapeutic diagnostic capabilities. In particular, plasmonic nanoparticles show remarkable potential due dual functionalities as photothermal therapy agents radiosensitizers radiotherapy. Their functionality, high biocompatibility, easy functionalization, targeting capabilities make them for inducing efficient cell death minimal effects. This review aims identify main challenges diagnosis colorectal cancer. The heterogeneous nature also discussed from single-cell point view. relevant works photo- radiotherapy nanotechnology-based therapies are addressed, ranging vitro studies (2D 3D cultures) vivo clinical trials. Although results promising, preliminary showed that possibility combining must be explored improve efficiency.
Language: Английский
Citations
29
Cancer Letters, Journal Year: 2023, Volume and Issue: 558, P. 216106 - 216106
Published: Feb. 24, 2023
Language: Английский
Citations
28
Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 164, P. 112409 - 112409
Published: April 12, 2024
Language: Английский
Citations
15
Nanotheranostics, Journal Year: 2024, Volume and Issue: 8(3), P. 344 - 379
Published: Jan. 1, 2024
Modern medicine relies on a small number of key biologics, which can be found in nature but require further characterization and purification before they used.Since the herbal remedy is given through dated ineffective method drug administration, its effectiveness diminished.The novel form delivery has potential to increase substances while decreasing their side effects.This main idea behind utilising different ways treatments.Several benefits arise from formulations compounds as compared conventional counterparts.These include enhanced penetrating ability into tissues, constant effective doses, resistance physical chemical degradation.Controlled targeted that components allow for more traditional dosing simultaneously increasing efficacy.Enhancing biodistribution target site accumulation systemically administered medicines goal nanomedicine formulations.The field nanotheranostics made significant advancements development by combining diagnostic therapeutic functions single nanoscale platform.It critically important create theranostic nanoplatform derived plants intrinsically "all-in-one" molecules.In addition examining mechanistic approach nanoparticle synthesis, this review highlights effects phytochemical systems.Furthermore, we have evaluated scope future field, discussed several nanoparticles been developed recently imaging, provided experimental evidence supports usage.
Language: Английский
Citations
12
ChemMedChem, Journal Year: 2024, Volume and Issue: 19(8)
Published: Jan. 24, 2024
This review article spotlights the burgeoning potential of using nanotherapeutic strategies to target long non-coding RNAs (lncRNAs) in cancer cells. updated discourse underlines prominent role lncRNAs instigating cancer, facilitating its progression, and metastasis, validating lncRNAs' for being effective diagnostic biomarkers therapeutic targets. The manuscript offers an in-depth examination different presently employed modulate lncRNA expression function purposes. Among these strategies, Antisense Oligonucleotides (ASOs), RNA interference (RNAi) technologies, innovative clustered regularly interspaced short palindromic repeats (CRISPR)-based gene editing tools garner noteworthy mention. A significant section is dedicated nanocarriers their crucial drug delivery. These nanocarriers' efficiency targeting varied types cancers elaborated upon, importance targeted therapy. culminates by reaffirming promising prospects enhance accuracy diagnosis improve treatment efficacy. Consequently, new paths are opened more research innovation employing approaches against Thus, this comprehensive serves as a valuable resource that underscores vital various nano-strategies them treatment. Future should also focus on unraveling complex regulatory networks involving identifying fundamental functional interactions refine cancer.
Language: Английский
Citations
11