Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: July 29, 2023
Abstract
Interleukin-2
(IL-2)
and
its
receptor
(IL-2R)
are
essential
in
orchestrating
immune
responses.
Their
function
expression
the
tumor
microenvironment
make
them
attractive
targets
for
immunotherapy,
leading
to
development
of
IL-2/IL-2R-targeted
therapeutic
strategies.
However,
dynamic
interplay
between
IL-2/IL-2R
various
cells
their
dual
roles
promoting
activation
tolerance
presents
a
complex
landscape
clinical
exploitation.
This
review
discusses
pivotal
IL-2
IL-2R
tumorigenesis,
shedding
light
on
potential
as
diagnostic
prognostic
markers
manipulation
cancer.
It
underlines
necessity
balance
anti-tumor
activity
with
regulatory
T-cell
expansion
evaluates
strategies
such
dose
optimization
selective
targeting
enhanced
effectiveness.
The
article
explores
recent
advancements
field,
including
developing
genetically
engineered
variants,
combining
therapies
other
cancer
treatments,
benefits
multidimensional
approach
integrating
molecular
profiling,
immunological
analyses,
data.
concludes
that
deeper
understanding
interactions
within
is
crucial
realizing
full
IL-2-based
therapies,
heralding
promise
improved
outcomes
patients.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: June 8, 2023
Interleukin-10
(IL-10)
is
a
pleiotropic
cytokine
that
has
fundamental
role
in
modulating
inflammation
and
maintaining
cell
homeostasis.
It
primarily
acts
as
an
anti-inflammatory
cytokine,
protecting
the
body
from
uncontrolled
immune
response,
mostly
through
Jak1/Tyk2
STAT3
signaling
pathway.
On
other
hand,
IL-10
can
also
have
immunostimulating
functions
under
certain
conditions.
Given
pivotal
of
modulation,
this
could
relevant
implications
pathologies
characterized
by
hyperinflammatory
state,
such
cancer,
or
infectious
diseases
case
COVID-19
Post-COVID-19
syndrome.
Recent
evidence
proposed
predictor
severity
mortality
for
patients
with
acute
post-acute
SARS-CoV-2
infection.
In
context,
act
endogenous
danger
signal,
released
tissues
undergoing
damage
attempt
to
protect
organism
harmful
hyperinflammation.
Pharmacological
strategies
aimed
potentiate
restore
immunomodulatory
action
may
represent
novel
promising
avenues
counteract
storm
arising
hyperinflammation
effectively
mitigate
severe
complications.
Natural
bioactive
compounds,
derived
terrestrial
marine
photosynthetic
organisms
able
increase
expression,
useful
prevention
strategy
curb
elevation
will
be
discussed
here.
However,
multifaceted
nature
taken
into
account
attempts
modulate
its
levels.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: April 6, 2022
Oncolytic
viruses
(OVs)
are
emerging
as
potentially
useful
platforms
in
treatment
methods
for
patients
with
tumors.
They
preferentially
target
and
kill
tumor
cells,
leaving
healthy
cells
unharmed.
In
addition
to
direct
oncolysis,
the
essential
attractive
aspect
of
oncolytic
virotherapy
is
based
on
intrinsic
induction
both
innate
adaptive
immune
responses.
To
further
augment
this
efficacious
response,
OVs
have
been
genetically
engineered
express
regulators
that
enhance
or
restore
antitumor
immunity.
Recently,
combinations
other
immunotherapies,
such
checkpoint
inhibitors
(ICIs),
chimeric
antigen
receptors
(CARs),
antigen-specific
T-cell
(TCRs)
autologous
tumor-infiltrating
lymphocytes
(TILs),
led
promising
progress
cancer
treatment.
This
review
summarizes
mechanisms
OVs,
describes
optimization
strategies
using
armed
effects
immunity
highlights
rational
immunotherapies
recent
preclinical
clinical
studies.
Science Immunology,
Journal Year:
2022,
Volume and Issue:
7(70)
Published: April 1, 2022
Dendritic
cells
(DCs)
are
professional
antigen-presenting
cells,
orchestrating
innate
and
adaptive
immunity
during
infections,
autoimmune
diseases,
malignancies.
Since
the
discovery
of
DCs
almost
50
years
ago,
our
understanding
their
biology
in
humans
has
increased
substantially.
Here,
we
review
both
antitumor
tolerogenic
DC
responses
cancer
discuss
lineage-specific
contributions
by
functionally
specialized
subsets,
including
conventional
(cDC)
subsets
cDC1
cDC2,
newly
described
DC3,
plasmacytoid
(pDCs),
focusing
on
human
setting.
In
addition,
lineage-unrestricted
"mature
enriched
immunoregulatory
molecules"
(mregDC)
state
recently
across
different
tumors.
Nature,
Journal Year:
2023,
Volume and Issue:
625(7994), P. 377 - 384
Published: Dec. 6, 2023
Abstract
Cytokines
mediate
cell–cell
communication
in
the
immune
system
and
represent
important
therapeutic
targets
1–3
.
A
myriad
of
studies
have
highlighted
their
central
role
function
4–13
,
yet
we
lack
a
global
view
cellular
responses
each
cell
type
to
cytokine.
To
address
this
gap,
created
Immune
Dictionary,
compendium
single-cell
transcriptomic
profiles
more
than
17
types
response
86
cytokines
(>1,400
cytokine–cell
combinations)
mouse
lymph
nodes
vivo.
cytokine-centric
dictionary
revealed
that
most
induce
highly
cell-type-specific
responses.
For
example,
inflammatory
cytokine
interleukin-1β
induces
distinct
gene
programmes
almost
every
type.
cell-type-centric
identified
66
cytokine-driven
polarization
states
across
types,
including
previously
uncharacterized
such
as
an
interleukin-18-induced
polyfunctional
natural
killer
state.
Based
on
dictionary,
developed
companion
software,
Response
Enrichment
Analysis,
for
assessing
activities
from
expression
data,
applied
it
reveal
networks
tumours
following
checkpoint
blockade
therapy.
Our
generates
new
hypotheses
functions,
illuminates
pleiotropic
effects
cytokines,
expands
our
knowledge
activation
type,
provides
framework
deduce
roles
specific
any
response.
Tropical Medicine and Infectious Disease,
Journal Year:
2024,
Volume and Issue:
9(1), P. 13 - 13
Published: Jan. 4, 2024
Interleukins
(ILs)
are
signaling
molecules
that
crucial
in
regulating
immune
responses
during
infectious
diseases.
Pro-inflammatory
ILs
contribute
to
the
activation
and
recruitment
of
cells,
whereas
anti-inflammatory
help
suppress
excessive
inflammation
promote
tissue
repair.
Here,
we
provide
a
comprehensive
overview
role
pro-inflammatory
diseases,
with
focus
on
mechanisms
underlying
their
effects,
diagnostic
therapeutic
potential,
emerging
trends
IL-based
therapies.
Advanced Drug Delivery Reviews,
Journal Year:
2022,
Volume and Issue:
182, P. 114112 - 114112
Published: Jan. 24, 2022
Cytokines
are
a
class
of
potent
immunoregulatory
proteins
that
secreted
in
response
to
various
stimuli
and
act
locally
regulate
many
aspects
human
physiology
disease.
play
important
roles
cancer
initiation,
progression,
elimination,
thus,
there
is
long
clinical
history
associated
with
the
use
recombinant
cytokines
treat
cancer.
However,
as
therapeutics
has
been
limited
by
cytokine
pleiotropy,
complex
biology,
poor
drug-like
properties,
severe
dose-limiting
toxicities.
Nevertheless,
crucial
mediators
innate
adaptive
antitumor
immunity
have
potential
enhance
immunotherapeutic
approaches
Development
immune
checkpoint
inhibitors
combination
immunotherapies
reinvigorated
interest
therapeutics,
variety
engineering
emerging
improve
safety
effectiveness
immunotherapy.
In
this
review
we
highlight
recent
advances
biology
for
