The emerging role of the gut microbiota and its application in inflammatory bowel disease

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117302 - 117302

Published: Aug. 19, 2024

Inflammatory bowel disease (IBD), including Crohn's and ulcerative colitis, is a complex disorder with an unknown cause. However, the dysbiosis of gut microbiome has been found to play role in IBD etiology, exacerbated immune responses defective intestinal barrier integrity. The can also be potential biomarker for several diseases, IBD. Currently, conventional treatments targeting pro-inflammatory cytokines pathways IBD-associated do not yield effective results. Other therapies that directly target dysbiotic outcomes are emerging. We review health its as diagnostic, prognostic, therapeutic This explores emerging advancements microbiome-associated alterations IBD, such nanoparticle or encapsulation delivery, fecal microbiota transplantation, nutritional therapies, microbiome/probiotic engineering, phage therapy, mesenchymal stem cells (MSCs), proteins, herbal formulas.

Language: Английский

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Exploring the Complexities of Long COVID

Viruses, Journal Year: 2024, Volume and Issue: 16(7), P. 1060 - 1060

Published: June 30, 2024

Since the emergence of SARS-CoV-2 virus in 2019, nearly 700 million COVID-19 cases and 7 deaths have been reported globally. Despite most individuals recovering within four weeks, Center for Disease Control (CDC) estimates that 7.5% to 41% develop post-acute infection syndrome (PAIS), known as 'Long COVID'. This review provides current statistics on Long COVID's prevalence, explores hypotheses concerning epidemiological factors, such age, gender, comorbidities, initial severity, vaccine interactions, delves into potential mechanisms, including immune responses, viral persistence, gut dysbiosis. Moreover, we conclude women, advanced non-vaccination, low socioeconomic status all appear be risk factors. The reasons these differences are still not fully understood likely involve a complex relationship between social, genetic, hormonal, other Furthermore, with seem more endure economic hardship due persistent symptoms. In summary, our findings further illustrate multifaceted nature COVID underscore importance understanding factors mechanisms needed effective therapeutic strategies interventions.

Language: Английский

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Immunomodulatory hydrogel orchestrates pro-regenerative response of macrophages and angiogenesis for chronic wound healing

Biomaterials, Journal Year: 2024, Volume and Issue: 314, P. 122848 - 122848

Published: Sept. 24, 2024

Language: Английский

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Cadmium-induced augmentation of fungal translocation promotes systemic infection in mice via gut barrier disruption and immune dysfunction

Life Sciences, Journal Year: 2025, Volume and Issue: 362, P. 123368 - 123368

Published: Jan. 4, 2025

Language: Английский

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Interleukin-10 exhibit dose-dependent effects on macrophage phenotypes and cardiac remodeling after myocardial infarction

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 15, 2025

Interleukin-10 (IL-10) is a potent immunomodulatory cytokine widely explored as therapeutic agent for diseases, including myocardial infarction (MI). High-dose IL-10 treatment may not achieve expected outcomes, raising the question of whether has dose-dependency, or even uncharted side-effects from overdosing. We hypothesized that dose-dependent effects on macrophage (Mφ) phenotypic transition and cardiac remodeling after MI. Using RAW264.7 monocyte models, we examined administering differential doses exogenous (0-1,000 ng/mL) perturbs classic M1 (pro-inflammatory) M2 (anti-inflammatory) phenotypes polarized Mφ alters prospective polarization. then investigated impact single intramyocardial administration function, structure, inflammation post-MI, using mouse MI model. Compared with 0-ng/mL control, 250-ng/mL had strongest overall in decreasing increasing while ≥500-ng/mL dampened polarization augmented native secretion more effectively than low vitro. Echocardiography revealed 250-ng group consistently higher contractile function lower left ventricular (LV) dilatation saline control over 6 weeks ≥1,000-ng groups exhibited transient LV ejection fraction at 5 days post-MI vivo. Moreover, different differentially modulated gene expression, phagocytic cell infiltration infarct, fibrosis, revascularization some, but all, exerting beneficial effects. Our study suggested an effective dose range phenotypes, trigger cardioprotective unwanted manner.

Language: Английский

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N,N-dimethylacetamide blocks inflammation-induced preterm birth and remediates maternal systemic immune responses

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Abstract The common excipient, N,N-dimethylacetamide (DMA), prevents imminent endotoxin-induced preterm birth in mice. present study hypothesized that DMA forestalls to term (defined as day 18.5 or later) by attenuating bacterial endotoxin lipopolysaccharide (LPS)–induced maternal systemic inflammatory responses and cervix remodeling. Accordingly, LPS (i.p.) on 15 postbreeding stimulated delivery within 24 h while mice treated with 2 preceding 9 following administration remained pregnant, comparable saline controls, deliver viable pups at term. Irrespective of DMA+LPS treatment, plasma pro- anti-inflammatory cytokines 15.5 (12 post-LPS) increased 10-fold compared baseline concentrations controls. On 16 pregnancy, G-CSF TNFα were reduced the prepartum LPS+DMA group those postpartum given LPS. By 18 all returned - equivalent low levels throughout controls gave In addition, progesterone declined 12 LPS-treated 16. Although a similar transient decrease occurred mice, Contemporaneously, progression remodeling leading was acutely forestalled without impeding These findings support hypothesis not only inflammation-driven birth, but rescues pregnancy for occur results raise possibility signals can forecast risk selective suppression inflammation mitigate adverse outcomes. Summary from inflammation-induced through progesterone-independent mechanism involves multiple proinflammatory circulation. Supported NIH Grant 1R16GM145586 Ines Mandl Research Foundation

Language: Английский

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Bacterial Systems as a Precision Delivery Platform of Therapeutic Peptides for Cancer Therapy

Polymer science & technology., Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

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Cortical thickness alterations and systemic inflammation define long-COVID patients with cognitive impairment

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 116, P. 175 - 184

Published: Nov. 28, 2023

As the heterogeneity of symptoms is increasingly recognized among long-COVID patients, it appears highly relevant to study potential pathophysiological differences along different subtypes. Preliminary evidence suggests distinct alterations in brain structure and systemic inflammatory patterns specific groups patients. To this end, we analyzed cortical thickness peripheral immune signature between clinical subgroups based on 3 T-MRI scans markers n = 120 participants comprising healthy never-infected controls (n 30), COVID-19 survivors 29), patients with 26) without 35) cognitive impairment according screening Montreal Cognitive Assessment. Whole-brain comparison 4 was conducted by surface-based morphometry. We identified areas showing a progressive increase across groups, starting from individuals who had never been infected COVID-19, followed survivors, deficits (MoCA ≥ 26), finally, exhibiting significant < 26). These findings highlight continuum associated more pronounced changes observed experiencing (p 0.05, FWE-corrected). Affected regions covered prefrontal temporal gyri, insula, posterior cingulate, parahippocampal gyrus, parietal areas. Additionally, discovered immunophenotype, elevated levels IL-10, IFNγ, sTREM2 especially group suffering impairment. demonstrate lingering immunological impaired survivors. This implies complex underlying pathomechanism emphasizes necessity investigate whole spectrum post-COVID biology determine targeted treatment strategies targeting sub-groups.

Language: Английский

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The complex role of IL-10 in malignant ascites: a review

Cancer Immunology Immunotherapy, Journal Year: 2024, Volume and Issue: 73(2)

Published: Jan. 27, 2024

Abstract The emergence of malignant ascites (MA) indicates poor prognoses in patients with ovarian, gastrointestinal, breast, and pancreatic cancer. Interleukin-10 (IL-10) is a pleiotropic cytokine immunoregulatory effects tumor microenvironment. level IL-10 MA varied across cancer types patients, influencing progression outcomes. Originating from various immune cells, contributes to complex signaling pathways MA. Systemic administration, although the evidence its efficacy on limited, still emerges as promising therapeutic strategy because it can increase CD8+ T cells cytotoxicity invigorate exhausted infiltration lymphocytes (TILs) directly. blockade also demonstrates great potential when combined other immunotherapies treatment. We reviewed levels, origins, functions overviewed current targeting therapies, aiming provide insights for

Language: Английский

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Macrophages and Gut Barrier Function: Guardians of Gastrointestinal Health in Post-Inflammatory and Post-Infection Responses

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9422 - 9422

Published: Aug. 30, 2024

The gut barrier is essential for protection against pathogens and maintaining homeostasis. Macrophages are key players in the immune system, indispensable intestinal health, contribute to defense repair mechanisms. Understanding multifaceted roles of macrophages can provide critical insights into restoring gastrointestinal (GI) health. This review explores role function their contribution post-inflammatory post-infectious responses gut. significantly integrity through epithelial repair, modulation, interactions with microbiota. They demonstrate active plasticity by switching phenotypes resolve inflammation, facilitate tissue regulate microbial populations following an infection or inflammation. In addition, tissue-resident (M2) infiltration (M1) convert each other problems such as IBS IBD via major signaling pathways mediated NF-κB, JAK/STAT, PI3K/AKT, MAPK, Toll-like receptors, specific microRNAs miR-155, miR-29, miR-146a, miR-199, which may be good targets new therapeutic approaches. Future research should focus on elucidating detailed molecular mechanisms developing personalized approaches fully harness potential maintain restore permeability

Language: Английский

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