Circulation Research,
Journal Year:
2024,
Volume and Issue:
134(12), P. 1703 - 1717
Published: June 6, 2024
Fibroblasts
are
essential
for
building
and
maintaining
the
structural
integrity
of
all
organs.
Moreover,
fibroblasts
can
acquire
an
inflammatory
phenotype
to
accommodate
immune
cells
in
specific
niches
provide
migration,
differentiation,
growth
factors.
In
heart,
balancing
fibroblast
activity
is
critical
cardiac
homeostasis
optimal
organ
function
during
inflammation.
sustain
by
generating
local
niche
environments
that
support
housekeeping
functions
actively
engaging
intercellular
cross
talk.
During
perturbations,
rapidly
switch
state
communicate
with
infiltrating
orchestrate
cell
migration
activity.
Here,
we
summarize
current
knowledge
on
molecular
landscape
fibroblasts,
focusing
their
dual
role
promoting
tissue
modulating
cell–cardiomyocyte
interaction.
addition,
discuss
potential
future
avenues
manipulating
myocardial
Nano Letters,
Journal Year:
2023,
Volume and Issue:
23(16), P. 7350 - 7357
Published: Aug. 14, 2023
The
mechanical
properties
of
soft
tissues
can
often
be
strongly
correlated
with
the
progression
various
diseases,
such
as
myocardial
infarction
(MI).
However,
dynamic
cardiac
during
MI
remain
poorly
understood.
Herein,
we
investigate
rheological
responses
at
different
stages
(i.e.,
early-stage,
mid-stage,
and
late-stage)
atomic
force
microscopy-based
microrheology.
Surprisingly,
discover
that
all
exhibit
a
universal
two-stage
power-law
behavior
time
scales.
experimentally
found
exponents
capture
an
inconspicuous
initial
change,
making
them
particularly
suitable
markers
for
early-stage
diagnosis.
We
further
develop
self-similar
hierarchical
model
to
characterize
progressive
changes
from
subcellular
tissue
theoretically
calculated
indexes
are
markedly
vary
among
MI.
These
new
applicable
tracking
subtle
progression.
Frontiers in Physiology,
Journal Year:
2023,
Volume and Issue:
14
Published: March 9, 2023
Cardiac
fibrosis
is
defined
as
excessive
deposition
of
extracellular
matrix
(ECM)
in
pathological
conditions.
fibroblasts
(CFs)
activated
by
injury
or
inflammation
differentiate
into
myofibroblasts
(MFs)
with
secretory
and
contractile
functions.
In
the
fibrotic
heart,
MFs
produce
ECM
which
composed
mainly
collagen
initially
involved
maintaining
tissue
integrity.
However,
persistent
disrupts
coordination
excitatory
coupling,
leading
to
systolic
diastolic
dysfunction,
ultimately
heart
failure.
Numerous
studies
have
demonstrated
that
both
voltage-
non-voltage-gated
ion
channels
alter
intracellular
levels
cellular
activity,
contributing
myofibroblast
proliferation,
contraction,
function.
an
effective
treatment
strategy
for
myocardial
has
not
been
established.
Therefore,
this
review
describes
progress
made
research
related
transient
receptor
potential
(TRP)
channels,
Piezo1,
Ca
2+
release-activated
(CRAC)
voltage-gated
(VGCCs),
sodium
potassium
aim
providing
new
ideas
treating
fibrosis.
Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Jan. 31, 2024
Abstract
Background
Esophageal
strictures
significantly
impair
patient
quality
of
life
and
present
a
therapeutic
challenge,
particularly
due
to
the
high
recurrence
post-ESD/EMR.
Current
treatments
manage
symptoms
rather
than
addressing
disease's
etiology.
This
review
concentrates
on
mechanisms
esophageal
stricture
formation
recurrence,
seeking
highlight
areas
for
potential
intervention.
Methods
A
literature
search
was
conducted
through
PUBMED
using
terms:
stricture,
mucosal
resection,
submucosal
dissection.
Relevant
articles
were
identified
manual
with
reference
lists
reviewed
additional
articles.
Results
Preclinical
studies
data
from
animal
suggest
that
may
lead
include
overdifferentiation
fibroblasts,
inflammatory
response
is
not
healed
in
time,
impaired
epithelial
barrier
function,
multimethod
factors
leading
it.
Dysfunction
be
initiating
mechanism
stricture.
Achieving
perfect
in-epithelialization
by
tissue-engineered
fabrication
cell
patches
has
been
shown
effective
treatment
prevention
strictures.
Conclusion
The
development
involves
three
stages:
structural
damage
(EEB),
chronic
inflammation,
severe
fibrosis,
which
dysfunction
or
EEB
Re-epithelialization
essential
information
will
help
clinicians
scientists
develop
techniques
treat
future.
Circulation Research,
Journal Year:
2024,
Volume and Issue:
134(12), P. 1703 - 1717
Published: June 6, 2024
Fibroblasts
are
essential
for
building
and
maintaining
the
structural
integrity
of
all
organs.
Moreover,
fibroblasts
can
acquire
an
inflammatory
phenotype
to
accommodate
immune
cells
in
specific
niches
provide
migration,
differentiation,
growth
factors.
In
heart,
balancing
fibroblast
activity
is
critical
cardiac
homeostasis
optimal
organ
function
during
inflammation.
sustain
by
generating
local
niche
environments
that
support
housekeeping
functions
actively
engaging
intercellular
cross
talk.
During
perturbations,
rapidly
switch
state
communicate
with
infiltrating
orchestrate
cell
migration
activity.
Here,
we
summarize
current
knowledge
on
molecular
landscape
fibroblasts,
focusing
their
dual
role
promoting
tissue
modulating
cell–cardiomyocyte
interaction.
addition,
discuss
potential
future
avenues
manipulating
myocardial
