Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(7), P. 1209 - 1224
Published: June 19, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: Oct. 9, 2023
Abstract Individual variability in drug response (IVDR) can be a major cause of adverse reactions (ADRs) and prolonged therapy, resulting substantial health economic burden. Despite extensive research pharmacogenomics regarding the impact individual genetic background on pharmacokinetics (PK) pharmacodynamics (PD), diversity explains only limited proportion IVDR. The role gut microbiota, also known as second genome, its metabolites modulating therapeutic outcomes human diseases have been highlighted by recent studies. Consequently, burgeoning field pharmacomicrobiomics aims to explore correlation between microbiota variation IVDR or ADRs. This review presents an up-to-date overview intricate interactions classical agents for systemic diseases, including cancer, cardiovascular (CVDs), endocrine others. We summarise how directly indirectly, modify absorption, distribution, metabolism, excretion (ADME) drugs. Conversely, drugs modulate composition function leading changes microbial metabolism immune response. discuss practical challenges, strategies, opportunities this field, emphasizing critical need develop innovative approach multi-omics, integrate various data types, genomic data, well translate lab into clinical practice. To sum up, represents promising avenue address improve patient outcomes, further is imperative unlock full potential precision medicine.
Language: Английский
Citations
83
Nature Reviews Cardiology, Journal Year: 2024, Volume and Issue: 21(9), P. 617 - 631
Published: April 10, 2024
Language: Английский
Citations
75
Circulation, Journal Year: 2023, Volume and Issue: 148(6), P. 459 - 472
Published: July 12, 2023
BACKGROUND: Gut microbiota have been implicated in atherosclerotic disease, but their relation with subclinical coronary atherosclerosis is unclear. This study aimed to identify associations between the gut microbiome and computed tomography–based measures of explore relevant clinical correlates. METHODS: We conducted a cross-sectional 8973 participants (50 65 years age) without overt disease from population-based SCAPIS (Swedish Cardiopulmonary Bioimage Study). Coronary was measured using artery calcium score tomography angiography. species abundance functional potential were assessed shotgun metagenomics sequencing fecal samples, evaluated multivariable regression models adjusted for cardiovascular risk factors. Associated association inflammatory markers, metabolites, corresponding saliva. RESULTS: The mean age sample 57.4 years, 53.7% female. calcification detected 40.3%, 5.4% had at least 1 stenosis >50% occlusion. Sixty-four associated independent factors, strongest observed Streptococcus anginosus oralis subsp ( P <1×10 –5 ). Associations largely similar across angiography–based measurements. Out 64 species, 19 including streptococci other commonly found oral cavity, high-sensitivity C-reactive protein plasma concentrations, 16 neutrophil counts. microbial that are cavity negatively indole propionate positively secondary bile acids imidazole propionate. Five 3 streptococci, correlated same saliva worse dental health Malmö Offspring Dental Study. Microbial dissimilatory nitrate reduction, anaerobic fatty acid β-oxidation, amino degradation score. CONCLUSIONS: provides evidence an composition characterized by increased spp systemic inflammation markers. Further longitudinal experimental studies warranted implications bacterial component atherogenesis.
Language: Английский
Citations
57
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 26, 2024
The gut microbiome is a heterogeneous population of microbes comprising viruses, bacteria, fungi, and protozoa. Such essential for sustaining host equilibrium, its impact on human health can be altered by variety factors such as external variables, social behavior, age, nutrition, genetics. Gut microbes’ imbalances are related to chronic diseases including cancer, obesity, digestive disorders. Globally, recent findings show that intestinal have significant role in the formation cardiovascular disease (CVD), which still primary cause fatalities. Atherosclerosis, hypertension, diabetes, inflammation, some inherited variables all risk variables. However, studies found correlations between metabolism, flora, dietary intake. Variations diversity changes their activity thought influence CVD etiology. Furthermore, microbiota acts an endocrine organ, producing bioactive metabolites TMA (trimethylamine)/TMAO (trimethylamine N-oxide), SCFA (short-chain fatty acids), bile acids, substantial wellness multiple mechanisms. purpose this overview compile current evidence highlighting intricate links microbiota, metabolites, development CVD. It focuses how dysbiosis promotes heart failure, atherosclerosis. This review explores normal physiology potential techniques targeting bacteria treatment using various microbial metabolites. also examines significance treatment, supplements, prebiotics, probiotics, antibiotic therapies, fecal transplantation, innovative approach management As result, metabolic pathways become increasingly attractive targets intervention.
Language: Английский
Citations
42
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 14, 2024
Recent studies have indicated that gut microbiota-mediated oxidative stress is significantly associated with intestinal diseases such as colorectal cancer, ulcerative colitis, and Crohn’s disease. The level of reactive oxygen species (ROS) has been reported to increase when the microbiota dysregulated, especially several bacterial metabolites are present. Although healthy plays a vital role in defending against excessive stress, disease influenced by ROS, this process controlled immunological responses, DNA damage, inflammation. In review, we discuss relationship between from an perspective. addition, also provide summary most recent therapeutic approaches for preventing or treating modifying microbiota.
Language: Английский
Citations
36
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: May 6, 2024
Abstract Probiotic and engineered microbe-based therapeutics are an emerging class of pharmaceutical agents. They represent a promising strategy for treating various chronic inflammatory conditions by interacting with the host immune system and/or delivering therapeutic molecules. Here, we targeted probiotic yeast platform wherein Saccharomyces boulardii is designed to bind abundant extracellular matrix proteins found within lesions gastrointestinal tract through tunable antibody surface display. This approach enabled additional 24–48 h gut residence time compared controls 100-fold increased concentrations colon in preclinical models ulcerative colitis female mice. As result, pharmacodynamic parameters including length, colonic cytokine expression profiles, histological inflammation scores were robustly improved restored back healthy levels. Overall, these studies highlight potential microbial as oral dosage form treatment bowel diseases.
Language: Английский
Citations
25
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Sept. 23, 2024
Language: Английский
Citations
20
European Journal of Preventive Cardiology, Journal Year: 2023, Volume and Issue: 30(12), P. 1274 - 1282
Published: May 17, 2023
Abstract Aims Studies have linked gut microbiome and heart failure (HF). However, their causal relationships potential mediating factors not been well defined. To investigate the between HF effect of blood lipids by using genetics. Methods results We performed a bidirectional mediation Mendelian randomization (MR) study summary statistics from genome-wide association studies microbial taxa (Dutch Microbiome Project, n = 7738), (UK Biobank, 115 078), meta-analysis (115 150 cases 1550 331 controls). applied inverse–variance weighted estimation method as primary method, with several other estimators complementary methods. The multivariable MR approach based on Bayesian model averaging (MR-BMA) was used to prioritize most likely lipids. Six are suggestively associated causally. significant taxon species Bacteroides dorei [odds ratio 1.059, 95% confidence interval (CI) 1.022–1.097, P-value 0.0017]. MR-BMA analysis showed that apolipoprotein B (ApoB) lipid for (the marginal inclusion probability 0.717, 0.005). ApoB mediated effects B. (proportion 10.1%, CI 0.2–21.6%, 0.031). Conclusion suggested relationship specific might mediate this determinant HF.
Language: Английский
Citations
38
Foods, Journal Year: 2023, Volume and Issue: 12(10), P. 2010 - 2010
Published: May 16, 2023
Pleurotus ostreatus (Jacq. ex Fr.) P. Kumm mushroom contains bioactive compounds with both antimicrobial and prebiotic properties, which are distributed in the mycelium, fruiting body, spent substrate. The is rich nondigestible carbohydrates like chitin glucan, act as prebiotics support growth activity of beneficial gut bacteria, thereby maintaining a healthy balance microbiota reducing risk antibiotic resistance. mushrooms, including polysaccharides (glucans, chitin) secondary metabolites (phenolic compounds, terpenoids, lectins), exhibit antibacterial, antiviral, antifungal activities. When mushrooms consumed, these can help preventing spread harmful bacteria gut, infections development Nonetheless, further research necessary to determine efficacy against different pathogens fully comprehend its properties. Overall, consuming diet mushroom-based foods have positive impact on human digestion health. A microbiome reduce need for antibiotics.
Language: Английский
Citations
37
Nutrients, Journal Year: 2023, Volume and Issue: 15(8), P. 1850 - 1850
Published: April 12, 2023
Despite advances in preventive measures and treatment options, cardiovascular disease (CVD) remains the number one cause of death globally. Recent research has challenged traditional risk factor profile highlights potential contribution non-traditional factors CVD, such as gut microbiota its metabolites. Disturbances have been repeatedly associated with including atherosclerosis hypertension. Mechanistic studies support a causal role microbiota-derived metabolites development, short-chain fatty acids, trimethylamine-N-oxide, bile latter being elaborately discussed this review. Bile acids represent class cholesterol derivatives that is essential for intestinal absorption lipids fat-soluble vitamins, plays an important turnover and, more recently discovered, acts group signaling molecules exerts hormonal functions throughout body. Studies shown mediating roles control lipid metabolism, immunity, heart function. Consequently, picture emerged acting integrators modulators cardiometabolic pathways, highlighting their therapeutic targets CVD. In review, we provide overview alterations acid metabolism found CVD patients, describe molecular mechanisms through which may modulate risk, discuss bile-acid-based strategies relation to
Language: Английский
Citations
31