Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: April 27, 2025
Although
toxicity
of
alcohol
toward
the
intestines
and
immunity
is
mentioned,
there
might
be
different
effect
in
a
low
high
dose
rodent
model
development
using
simple
SHIRPA
binary
score
night
useful.
Hence,
(6.30
1.26
g/kg/day)
were
administered
for
16
weeks
before
determination
several
parameters.
As
such,
peak
blood
concentration
(BAC)
approximately
at
0.05
0.15%,
respectively,
1
h
post-administration,
which
correlated
with
1.8
±
0.8
7.2
0.6,
respectively.
After
wk
administration,
significant
liver
injury
high-dose
was
indicated
by
enzymes,
weight,
histology
score,
apoptosis,
hepatic
accumulation
triglyceride
(TG)
oxidative
stress
(malondialdehyde;
MDA)
reduced
anti-oxidant
(glutathione).
Meanwhile,
low-dose
demonstrated
only
elevated
apoptosis
increased
TG
MDA
tissue.
Leaky
gut
from
both
also
FITC-dextran,
endotoxemia,
serum
beta
glucan,
occludin.
However,
bacterial
abundance
(microbiome
analysis)
feces
small
bowel
alcohol,
but
not
dose,
control
(increased
Alitipes
spp.
Lachnospiraceae).
In
conclusion,
low-
induced
leaky
gut,
while
caused
dysbiosis
damaged
mitochondria
enhanced
glycolysis
enterocytes
macrophages.
more
sensitive
than
to
determine
alcohol-induced
intestinal
injury.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(20), P. 11242 - 11347
Published: Oct. 9, 2024
Biopsy,
including
tissue
and
liquid
biopsy,
offers
comprehensive
real-time
physiological
pathological
information
for
disease
detection,
diagnosis,
monitoring.
Fluorescent
probes
are
frequently
selected
to
obtain
adequate
on
processes
in
a
rapid
minimally
invasive
manner
based
their
advantages
biopsy.
However,
conventional
fluorescent
have
been
found
show
aggregation-caused
quenching
(ACQ)
properties,
impeding
greater
progresses
this
area.
Since
the
discovery
of
aggregation-induced
emission
luminogen
(AIEgen)
promoted
advancements
molecular
bionanomaterials
owing
unique
high
quantum
yield
(QY)
signal-to-noise
ratio
(SNR),
Circulation,
Journal Year:
2024,
Volume and Issue:
149(22), P. 1752 - 1769
Published: Feb. 13, 2024
BACKGROUND:
Vascular
calcification,
which
is
characterized
by
calcium
deposition
in
arterial
walls
and
the
osteochondrogenic
differentiation
of
vascular
smooth
muscle
cells,
an
actively
regulated
process
that
involves
complex
mechanisms.
calcification
associated
with
increased
cardiovascular
adverse
events.
The
role
4-hydroxynonenal
(4-HNE),
most
abundant
stable
product
lipid
peroxidation,
has
been
poorly
investigated.
METHODS:
Serum
was
collected
from
patients
chronic
kidney
disease
controls,
levels
4-HNE
8-iso-prostaglandin
F2α
were
measured.
Sections
coronary
atherosclerotic
plaques
donors
immunostained
to
analyze
4-HNE.
A
total
658
artery
who
received
computed
tomography
angiography
recruited
relationship
between
rs671
mutation
aldehyde
dehydrogenase
2
(
ALDH2
).
knockout
-/
-
)
mice,
cell–specific
transgenic
their
controls
used
establish
models.
Primary
mouse
aortic
cells
human
exposed
medium
containing
β-glycerophosphate
CaCl
investigate
cell
underlying
molecular
RESULTS:
Elevated
observed
serum
model
mice
detected
calcified
sections
immunostaining.
or
accelerated
development
whereas
overexpression
activation
prevented
cells.
In
disease,
gene
developed
more
severe
calcification.
promoted
both
vitro.
level
Runx2
(runt-related
transcription
factor-2),
effect
on
promoting
ablated
when
knocked
down.
Mutation
at
lysine
176
reduced
its
carbonylation
eliminated
4-HNE–induced
upregulation
Runx2.
CONCLUSIONS:
Our
results
suggest
increases
stabilization
directly
carbonylating
K176
site
promotes
might
be
a
potential
target
for
treatment
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 26, 2024
Abstract
Electrospinning
is
a
significant
manufacturing
strategy
to
create
micro/nanofiber
platforms
that
can
be
considered
biomedical
scaffold
for
tissue
engineering
repair
and
regeneration.
In
recent
years
researchers
have
continuously
broadened
the
equipment
design
materials
development
of
electrospinning
nanofiber
(ENPs),
which
evolved
from
single‐needle
multi‐needle
creating
3D
ENPs,
diversify
their
application
including
drugs/cell/growth
factors
release,
anti‐bacterial
anti‐inflammatory,
hemostasis,
wound
healing,
Herein,
multifunctional
ENPs
with
bioactive
polymer
fabricated
via
in
terms
novel
material
design,
construction
various
structures,
requirements
different
regeneration
are
reviewed.
Furthermore,
this
review
delves
into
advancements
facilitated
by
highlighting
effectiveness
versatility
across
types
such
as
bone,
cartilage,
tendons,
cardiac
tissue,
nerves.
The
discussion
comprehensively
addresses
ongoing
challenges
selection,
biodegradation
mechanisms,
bioactivation
strategies,
techniques
specific
applications.
Moreover,
outlines
potential
future
research
avenues
aimed
at
enhancing
ENPs‐based
approaches
engineering.
This
in‐depth
analysis
aims
provide
nuanced
insights
technical
recommendations
propel
field
forward
Nature Genetics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 4, 2025
Abstract
Heart
failure
(HF)
is
a
major
contributor
to
global
morbidity
and
mortality.
While
distinct
clinical
subtypes,
defined
by
etiology
left
ventricular
ejection
fraction,
are
well
recognized,
their
genetic
determinants
remain
inadequately
understood.
In
this
study,
we
report
genome-wide
association
study
of
HF
its
subtypes
in
sample
1.9
million
individuals.
A
total
153,174
individuals
had
HF,
whom
44,012
nonischemic
(ni-HF).
subset
patients
with
ni-HF
were
stratified
based
on
systolic
function,
where
data
available,
identifying
5,406
reduced
fraction
3,841
preserved
fraction.
We
identify
66
loci
associated
37
which
have
not
previously
been
reported.
Using
functionally
informed
gene
prioritization
methods,
predict
effector
genes
for
each
identified
locus,
map
these
etiologic
disease
clusters
through
phenome-wide
analysis,
network
analysis
colocalization.
Through
heritability
enrichment
highlight
the
role
extracardiac
tissues
etiology.
then
examine
differential
associations
upstream
risk
factors
using
Mendelian
randomization.
These
findings
extend
our
understanding
mechanisms
underlying
may
inform
future
approaches
prevention
treatment.
Pharmacology & Therapeutics,
Journal Year:
2024,
Volume and Issue:
259, P. 108666 - 108666
Published: May 17, 2024
Acute
myocardial
infarction
(AMI)
remains
a
leading
cause
of
death
worldwide.
Increased
formation
reactive
oxygen
species
(ROS)
during
the
early
reperfusion
phase
is
thought
to
trigger
lipid
peroxidation
and
disrupt
redox
homeostasis,
injury.
Whilst
mitochondrial
enzyme
aldehyde
dehydrogenase
2
(ALDH2)
chiefly
recognised
for
its
central
role
in
ethanol
metabolism,
substantial
experimental
evidence
suggests
an
additional
cardioprotective
ALDH2
independent
alcohol
intake,
which
mitigates
injury
by
detoxifying
breakdown
products
including
aldehydes,
malondialdehyde
(MDA)
4-hydroxynonenal
(4-HNE).
Epidemiological
that
mutant
variant
with
reduced
activity
highly
prevalent
East
Asian
population
increases
AMI
risk.
Additional
studies
have
uncovered
strong
association
between
coronary
heart
disease
this
variant.
It
appears
polymorphism
(in
particular,
ALDH2*2/2
carriers)
has
potential
wide-ranging
effects
on
thiol
reactivity,
tone
therefore
numerous
redox-related
signaling
processes,
resilience
cope
lifestyle-related
environmental
stressors,
ability
whole
body
achieve
balance.
In
review,
we
summarize
journey
from
reductase
linked
via
pre-clinical
aimed
at
stimulating
reduce
clinical
protective
heart.
Redox Biology,
Journal Year:
2024,
Volume and Issue:
76, P. 103318 - 103318
Published: Aug. 17, 2024
The
aldehyde
dehydrogenase
2
(ALDH2)
rs671
polymorphism
commonly
exists
in
the
East
Asian
populations
and
is
associated
with
high
risks
of
cardiovascular
disease
(CVD).
However,
cellular
molecular
mechanisms
that
underlie
ALDH2
mutant-linked
CVD
remain
elusive.
Here,
we
show
macrophages
derived
from
human
carriers
knockout
mice
exhibited
an
enhanced
pro-inflammatory
macrophage
phenotype
impaired
anti-inflammatory
phenotype.
Transplanting
bone
marrow
