Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Oct. 20, 2023
Abstract
Insufficient
drug
loading
and
leakage
of
payload
remain
major
challenges
in
designing
liposome-based
delivery
systems.
These
phenomena
can
limit
duration
effect
cause
toxicity.
Targeting
the
rate-limiting
step
release
from
liposomes,
we
modify
(aromatized)
them
to
have
aromatic
groups
within
their
lipid
bilayers.
Aromatized
liposomes
are
designed
with
synthetic
phospholipids
covalently
conjugated
onto
acyl
chains.
The
optimized
aromatized
liposome
increases
significantly
decreases
burst
a
broad
range
payloads
(small
molecules
macromolecules,
different
degrees
hydrophilicity)
extends
release.
encapsulating
anesthetic
tetrodotoxin
(TTX)
achieve
markedly
prolonged
decreased
toxicity
an
application
where
used
clinically:
local
anesthesia,
even
though
TTX
is
hydrophilic
small
molecule
which
typically
difficult
encapsulate.
Aromatization
bilayers
improve
performance
liposomal
Chemical Science,
Journal Year:
2022,
Volume and Issue:
13(15), P. 4239 - 4269
Published: Jan. 1, 2022
Small-molecule
prodrugs
have
become
the
main
toolbox
to
improve
unfavorable
physicochemical
properties
of
potential
therapeutic
compounds
in
contemporary
anti-cancer
drug
development.
Many
approved
small-molecule
prodrugs,
however,
still
face
key
challenges
their
pharmacokinetic
(PK)
and
pharmacodynamic
(PD)
properties,
thus
severely
restricting
further
clinical
applications.
Self-assembled
emerged
as
they
could
take
advantage
benefits
both
prodrug
design
nanomedicine,
so
maximize
loading,
reduce
premature
leakage,
PK/PD
parameters
targeting
ability.
Notably,
temporally
spatially
controlled
release
drugs
at
cancerous
sites
be
achieved
by
encoding
various
activable
linkers
that
are
sensitive
chemical
or
biological
stimuli
tumor
microenvironment
(TME).
In
this
review,
we
comprehensively
summarized
recent
progress
made
development
single/multiple-stimulus-responsive
self-assembled
for
mono-
combinatorial
therapy.
A
special
focus
was
placed
on
conjugation
strategies
(polymer-drug
conjugates,
drug-drug
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Jan. 3, 2024
Abstract
Successful
oral
insulin
administration
can
considerably
enhance
the
quality
of
life
(QOL)
diabetes
patients
who
must
frequently
take
injections.
Oral
administration,
on
other
hand,
is
seriously
hampered
by
gastrointestinal
enzymes,
wide
pH
range,
mucus
and
mucosal
layers,
which
limit
bioavailability
to
≤
2%.
Therefore,
a
large
number
technological
solutions
have
been
proposed
increase
insulin,
in
polymeric
nanoparticles
(PNPs)
are
highly
promising
for
delivery.
The
recently
published
research
articles
chosen
this
review
based
applications
PNPs
with
strong
future
potential
delivery,
do
not
cover
all
related
work.
In
review,
we
will
summarize
controlled
release
mechanisms
latest
delivery
nanocarrier,
challenges
prospect.
This
serve
as
guide
investigators
wish
engineer
study
systems.
Graphical
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Oct. 20, 2023
Abstract
Insufficient
drug
loading
and
leakage
of
payload
remain
major
challenges
in
designing
liposome-based
delivery
systems.
These
phenomena
can
limit
duration
effect
cause
toxicity.
Targeting
the
rate-limiting
step
release
from
liposomes,
we
modify
(aromatized)
them
to
have
aromatic
groups
within
their
lipid
bilayers.
Aromatized
liposomes
are
designed
with
synthetic
phospholipids
covalently
conjugated
onto
acyl
chains.
The
optimized
aromatized
liposome
increases
significantly
decreases
burst
a
broad
range
payloads
(small
molecules
macromolecules,
different
degrees
hydrophilicity)
extends
release.
encapsulating
anesthetic
tetrodotoxin
(TTX)
achieve
markedly
prolonged
decreased
toxicity
an
application
where
used
clinically:
local
anesthesia,
even
though
TTX
is
hydrophilic
small
molecule
which
typically
difficult
encapsulate.
Aromatization
bilayers
improve
performance
liposomal
