Preclinical Therapeutic Efficacy of Extracellular Vesicles Derived from Adipose-Derived Mesenchymal Stromal/Stem Cells in Diabetic Wounds: a Systematic Review and Meta-Analysis DOI
Setareh Soltani,

Ahora Zahedi,

April Joy S. Vergara

et al.

Stem Cell Reviews and Reports, Journal Year: 2024, Volume and Issue: 20(8), P. 2016 - 2031

Published: July 6, 2024

Language: Английский

Nano/microencapsulation of plant biocontrol agents by chitosan, alginate, and other important biopolymers as a novel strategy for alleviating plant biotic stresses DOI
Roohallah Saberi Riseh, Mohadeseh Hassanisaadi,

Masoumeh Vatankhah

et al.

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 222, P. 1589 - 1604

Published: Oct. 4, 2022

Language: Английский

Citations

86
Biocatalytic cascade in tumor microenvironment with a Fe2O3/Au hybrid nanozyme for synergistic treatment of triple negative breast cancer DOI
Xuemei Zeng,

Yihang Ruan,

Qi Chen

et al.

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 452, P. 138422 - 138422

Published: Aug. 2, 2022

Language: Английский

Citations

77
Innovative nanomaterials for cancer diagnosis, imaging, and therapy: Drug delivery applications DOI
Mehrab Pourmadadi,

Mohammad Mahdi Eshaghi,

Shima Ostovar

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 82, P. 104357 - 104357

Published: March 12, 2023

Language: Английский

Citations

49
Recent advances in two-dimensional metal-organic frameworks as an exotic candidate for the evaluation of redox-active sites in energy storage devices DOI

Nimra Muzaffar,

Amir Muhammad Afzal, H.H. Hegazy

et al.

Journal of Energy Storage, Journal Year: 2023, Volume and Issue: 64, P. 107142 - 107142

Published: March 22, 2023

Language: Английский

Citations

47
Dual targeting procyanidin nanoparticles with glutathione response for colitis treatment DOI
Shanshan Tie, Wentao Su, Yannan Chen

et al.

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 441, P. 136095 - 136095

Published: March 29, 2022

Language: Английский

Citations

64
Crosstalk between MiRNAs/lncRNAs and PI3K/AKT signaling pathway in diabetes mellitus: Mechanistic and therapeutic perspectives DOI Creative Commons
Seyed Mohsen Aghaei Zarch

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(2), P. 486 - 507

Published: Jan. 14, 2024

Diabetes as a fastest growing diseases worldwide is characterized by elevated blood glucose levels. There's an enormous financial burden associated with this endocrine disorder, unequal access to health care between developed and developing countries. PI3Ks (phosphoinositide 3-kinases) have been demonstrated be crucial for homeostasis, malfunctioning of these molecules can contribute increase in serum levels, the main pathophysiological feature diabetes. Additionally, recent evidence suggests that miRNAs lncRNAs are reciprocally interacting signaling pathway. It therefore evident abnormal regulation miRNAs/lncRNAs lncRNAs/miRNAs/PI3K/AKT axis related clinicopathological characteristics plays role biological processes. has attempted review describe interaction PI3K/AKT pathway various their importance DM biology. We also presented clinical applications PI3K/AKT-related ncRNAs/herbal medicine patients DM.

Language: Английский

Citations

12
Multifaceted therapeutic applications of biomimetic nanovaccines DOI Creative Commons

Dev Chheda,

Sukhen Shete,

Tanisha Tanisha

et al.

Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(6), P. 103991 - 103991

Published: April 23, 2024

The development of vaccines has had a crucial role in preventing and controlling infectious diseases on global scale. Innovative formulations biomimetic inspired by natural defense mechanisms combine long-term antigen stability, immunogenicity, targeted delivery with sustained release. Types nanoparticle (NP) include bacterial outer membrane vesicles (OMVs), cell membrane-decorated NPs, liposomes, exosomes. These approaches have shown potential for cancer immunotherapy, antibacterial antiviral applications. Despite current challenges, nanovaccines immense to transform disease prevention treatment, promising therapeutic the future. In this review, we highlight recent advances vaccine design, action, clinical applications, emphasizing their personalized medicine, drug delivery, immunomodulation.

Language: Английский

Citations

9
Advancements in Colorectal Cancer Treatment: The Role of Metal-Based and Inorganic Nanoparticles in Modern Therapeutic Approaches DOI
Maryam Azarian, Marzieh Ramezani Farani, William C. Cho

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 264, P. 155706 - 155706

Published: Nov. 6, 2024

Language: Английский

Citations

9
Ferroptosis-based nano delivery systems targeted therapy for colorectal cancer: Insights and future perspectives DOI Creative Commons
Qiao Chu, Haiying Wang,

Qiutong Guan

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2022, Volume and Issue: 17(5), P. 613 - 629

Published: Aug. 1, 2022

There are limited options for patients who develop liver metastasis from colorectal cancer (CRC), the leading cause of cancer-related mortality worldwide. Emerging evidence has provided insights into iron deficiency and excess in CRC. Ferroptosis is an iron-dependent form programmed cell death characterized by aberrant lipid metabolism, which play crucial roles tumorigenesis, tumor progression, treatment options. A better understanding underlying molecular mechanism ferroptosis shed light on current findings ferroptosis-based nanodrug targeting strategies, such as driving cells microenvironment, emerging combination therapy against multidrug resistance. Furthermore, this review highlights challenge perspective a ferroptosis-driven delivery system CRC-targeted therapy.

Language: Английский

Citations

32
Evaluation of pyrimidine/pyrrolidine-sertraline based hybrids as multitarget anti-Alzheimer agents: In-vitro, in-vivo, and computational studies DOI Open Access

Muhammad Aamir Javed,

Muhammad Saeed Jan, Abdullah M. Shbeer

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 159, P. 114239 - 114239

Published: Jan. 11, 2023

Alzheimer's disease (AD) is a complex, multifactorial and most prevalent progressive neurodegenerative ailment. Its complex nature causes the lack of modifying drugs. Hence, multi-target drug design strategies have been adopted to halt progression AD. In current research, we applied multitarget strategy tackle Rational synthesis framework hybrids containing Pyrimidine/pyrrolidine-sertraline scaffolds were carried out. The synthesized compounds further evaluated for their in-vitro enzyme inhibition potential against cholinesterases, monoamine oxidases β-site amyloid precursor protein cleaving enzyme-1 (BACE-1). Compound 19 emerged as an optimal multipotent hybrid with IC50 values 0.07 µM, 0.09 0.63 0.21 µM 0.73 AChE, BChE, MAO-A, MAO-B BACE-1 respectively. After in-vivo cytotoxicity PAMPA blood brain barrier permeation assays, number widely used behavioral assessment tests also performed evaluation memory learning.Determination biochemical parameters showed low levels acetylcholinesterase by treatment compounds. Furthermore, neurotransmitters such serotonin, dopamine noradrenaline analyzed. Increased neurotransmitter improved short long-term well enhanced learning behavior. Docking studies on target enzymes correlation experimental results.

Language: Английский

Citations

19