Cancer Cell, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
MedComm – Oncology, Journal Year: 2024, Volume and Issue: 3(1)
Published: Jan. 4, 2024
Abstract Epigenetic regulation refers to the alteration of gene expression independent changes in DNA sequence. It involves chemical modifications such as methylation, histone and acetylation, which are regulated by a coordinated interplay various regulators ensure precise spatial temporal expression. aberrations commonly observed cancer considered hallmarks cancer. In recent years, small molecules targeting specific epigenetic have been developed demonstrating promising therapeutic potential preclinical clinical trials for treatment. this review, we summarize essential regulatory mechanisms dysfunctions involved acetylation during tumor development progression. Moreover, discuss current advances challenges therapy that target these both hematologic malignancies solid tumors. Finally, combining drugs with other therapies, including chemotherapy, radiotherapy, targeted therapy, immunotherapy, approach Overall, aim enhance understanding explore strategies based on mechanisms, ultimately advance improve patient prognosis.
Language: Английский
Citations
22
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 254, P. 155174 - 155174
Published: Jan. 26, 2024
Breast cancer remains a major global health challenge. Its rising incidence is attributed to factors such as delayed diagnosis, the complexity of its subtypes, and increasing drug resistance, all contributing less-than-ideal patient outcomes. Central progression breast are epigenetic aberrations, which significantly contribute resistance emergence stem cell traits. These include alterations in DNA methylation, histone modifications, expression non-coding RNAs. Understanding these changes crucial for developing advanced management strategies despite their complexity. Investigating modifications offers potential novel diagnostic markers, more accurate prognostic indicators, identification reliable predictors treatment response. This could lead development new targeted therapies. However, this requires sustained, focused research efforts navigate challenges understanding carcinogenesis underpinnings. A deeper mechanisms can revolutionize personalized medicine. significant improvements care, including early detection, precise disease stratification, effective options.
Language: Английский
Citations
18
Cancers, Journal Year: 2025, Volume and Issue: 17(1), P. 154 - 154
Published: Jan. 6, 2025
Inflammation plays a crucial role in wound healing and the host immune response following pathogenic invasion. However, unresolved chronic inflammation can result tissue fibrosis genetic alterations that contribute to pathogenesis of human diseases such as cancer. Recent scientific advancements exploring underlying mechanisms malignant cellular transformations cancer progression have exposed significant disparities between pediatric adult-onset cancers. For instance, cancers tend lower mutational burdens arise actively developing tissues, where cell-cycle dysregulation leads gene, chromosomal, fusion gene development not seen counterparts. As such, findings adult cannot be directly applied cancers, unique mutations inherent etiologies remain poorly understood. Here, we review processes chromosomal instability, tumor microenvironment, tumorigenesis transformation explore current therapeutic interventions maintain and/or restore inflammatory homeostasis.
Language: Английский
Citations
3
International review of cell and molecular biology, Journal Year: 2025, Volume and Issue: unknown, P. xiii - xvii
Published: Jan. 1, 2025
Language: Английский
Citations
3
Cancer Cell, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
3