Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(11), P. 6891 - 6952

Published: May 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Language: Английский

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Second near-infrared photothermal materials for combinational nanotheranostics

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 50(2), P. 1111 - 1137

Published: Nov. 27, 2020

This review summarizes the recent development of second near-infrared photothermal combinational nanotheranostics for cancer, infectious diseases and regenerative medicine.

Language: Английский

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Photodynamic and Photothermal Therapies: Synergy Opportunities for Nanomedicine

ACS Nano, Journal Year: 2023, Volume and Issue: 17(9), P. 7979 - 8003

Published: April 27, 2023

Tumoricidal photodynamic (PDT) and photothermal (PTT) therapies harness light to eliminate cancer cells with spatiotemporal precision by either generating reactive oxygen species or increasing temperature. Great strides have been made in understanding biological effects of PDT PTT at the cellular, vascular tumor microenvironmental levels, as well translating both modalities clinic. Emerging evidence suggests that may synergize due their different mechanisms action, nonoverlapping toxicity profiles make such combination potentially efficacious. Moreover, PDT/PTT combinations gained momentum recent years development multimodal nanoplatforms simultaneously incorporate photodynamically- photothermally active agents. In this review, we discuss how combining can address limitations each modality alone enhance treatment safety efficacy. We provide an overview literature featuring dual nanoparticles analyze strengths various nanoparticle design strategies. also detail sequence dose affect cellular states, pathophysiology drug delivery, ultimately shaping response. Lastly, common experimental pitfalls complicate preclinical assessment propose rational guidelines elucidate underlying interactions.

Language: Английский

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Turning cold tumors into hot tumors by improving T-cell infiltration

Theranostics, Journal Year: 2021, Volume and Issue: 11(11), P. 5365 - 5386

Published: Jan. 1, 2021

Immunotherapy, represented by immune checkpoint inhibitors (ICIs), has greatly improved the clinical efficacy of malignant tumor therapy. ICI-mediated antitumor responses depend on infiltration T cells capable recognizing and killing cells. ICIs are not effective in "cold tumors", which characterized lack T-cell infiltration. To realize full potential immunotherapy solve this obstacle, it is essential to understand drivers into tumors. We present a critical review our understanding mechanisms underlying including impaired priming deficient homing beds. "Hot tumors" with significant associated better ICI efficacy. In review, we summarize multiple strategies that promote transformation "hot discuss these lead increased Finally, application nanomaterials provide an outlook future emerging field. The combination nanomedicines enhances cross-presentation antigens promotes A deeper opens new possibilities for development cell-based therapies improve effectiveness.

Language: Английский

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Engineering nanomedicine for glutathione depletion-augmented cancer therapy

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(10), P. 6013 - 6041

Published: Jan. 1, 2021

In this review, we systematically survey the most recent progress in engineering nanomedicine for intracellular glutathione consumption-augmented cancer therapy.

Language: Английский

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Targeting drugs to tumours using cell membrane-coated nanoparticles

Nature Reviews Clinical Oncology, Journal Year: 2022, Volume and Issue: 20(1), P. 33 - 48

Published: Oct. 28, 2022

Language: Английский

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Review on Recent Progress in Magnetic Nanoparticles: Synthesis, Characterization, and Diverse Applications

Frontiers in Chemistry, Journal Year: 2021, Volume and Issue: 9

Published: July 13, 2021

Diverse applications of nanoparticles (NPs) have revolutionized various sectors in society. In the recent decade, particularly magnetic (MNPs) gained enormous interest owing to their specialized areas such as medicine, cancer theranostics, biosensing, catalysis, agriculture, and environment. Controlled surface engineering for design multi-functional MNPs is vital achieving desired application. The demonstrated great efficacy thermoelectric materials, imaging agents, drug delivery vehicles, biosensors. present review, first we briefly discussed main synthetic methods MNPs, followed by characterizations composition. Then potential different with representative examples. At end, gave an overview on current challenges future prospects MNPs. This comprehensive review not only provides mechanistic insight into synthesis, functionalization, application but also outlines limits prospects.

Language: Английский

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Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency

Advanced Science, Journal Year: 2022, Volume and Issue: 9(22)

Published: June 2, 2022

Abstract Tumor immunotherapy is only effective in a fraction of patients due to low response rate and severe side effects, these challenges clinics can be addressed through induction immunogenic cell death (ICD). ICD elicited from many antitumor therapies release danger associated molecular patterns (DAMPs) tumor‐associated antigens facilitate maturation dendritic cells (DCs) infiltration cytotoxic T lymphocytes (CTLs). The process reverse the tumor immunosuppressive microenvironment improve sensitivity immunotherapy. Nanostructure‐based drug delivery systems (NDDSs) are explored induce by incorporating therapeutic molecules for chemotherapy, photosensitizers (PSs) photodynamic therapy (PDT), photothermal conversion agents (PTT), radiosensitizers radiotherapy (RT). These NDDSs loaded at right dose place time, resulting greater effectiveness lower toxicity. Immunotherapeutic also combined with achieve synergic effect multi‐modality approach. In this review, harnessed load multiple PDT, PTT, RT combination promote reduce effects cancer treatment.

Language: Английский

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Photodynamic Therapy—Current Limitations and Novel Approaches

Frontiers in Chemistry, Journal Year: 2021, Volume and Issue: 9

Published: June 10, 2021

Photodynamic therapy (PDT) mostly relies on the generation of singlet oxygen, via excitation a photosensitizer, so that target tumor cells can be destroyed. PDT applied in settings several malignant diseases. In fact, earliest preclinical applications date back to 1900’s. Dougherty reported treatment skin tumors by 1978. Several further studies around 1980 demonstrated effectiveness PDT. Thus, technique has attracted attention numerous researchers since then. Hematoporphyrin derivative received FDA approval as clinical application 1995. We have indeed witnessed considerable progress field over last century. Given fact favorable adverse event profile and enhance anti-tumor immune responses well demonstrating minimally invasive characteristics, it is disappointing not broadly utilized setting for and/or non-malignant issues still hinder development PDT, such those related with light, tissue oxygenation inherent properties photosensitizers. Various photosensitizers been designed/synthesized order overcome limitations. this Review, we provide general overview mechanisms action terms cancer, including effects system vasculature cell destruction. will also briefly mention The current limitations utilization cancer reviewed, identifying problems associated design/synthesis light might pave way more effective approaches. Furthermore, novel promising approaches improve outcome selectivity, bioengineering, subcellular/organelle targeting, etc. discussed detail, potential pioneering exceptional aim reveal full translation are undoubtedly exciting. A better understanding concepts ( e.g. enhanced, two-stage, fractional PDT) most likely prove very useful pursuing improving strategies.

Language: Английский

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Mito‐Bomb: Targeting Mitochondria for Cancer Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(43)

Published: Sept. 12, 2021

Abstract Cancer has been one of the most common life‐threatening diseases for a long time. Traditional cancer therapies such as surgery, chemotherapy (CT), and radiotherapy (RT) have limited effects due to drug resistance, unsatisfactory treatment efficiency, side effects. In recent years, photodynamic therapy (PDT), photothermal (PTT), chemodynamic (CDT) utilized owing their high selectivity, minor minimal toxicity. Accumulating evidence demonstrated that selective delivery drugs specific subcellular organelles can significantly enhance efficiency therapy. Mitochondria‐targeting therapeutic strategies are promising therapy, which is attributed essential role mitochondria in regulation cell apoptosis, metabolism, more vulnerable hyperthermia oxidative damage. Herein, rational design, functionalization, applications diverse mitochondria‐targeting units, involving organic phosphine/sulfur salts, quaternary ammonium (QA) peptides, transition‐metal complexes, guanidinium or bisguanidinium, well including PDT, PTT, CDT, others summarized. This review aims furnish researchers with deep insights hints design novel agents

Language: Английский

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