Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
203, P. 107185 - 107185
Published: April 12, 2024
Microbes,
including
bacteria,
viruses,
fungi,
and
other
eukaryotic
organisms,
are
commonly
present
in
multiple
organs
of
the
human
body
contribute
significantly
to
both
physiological
pathological
processes.
Nowadays,
development
sequencing
technology
has
revealed
presence
composition
intratumoral
microbiota,
which
includes
Fusobacterium,
Bifidobacteria,
Bacteroides,
shed
light
on
significant
involvement
progression
colorectal
cancer
(CRC).
Here,
we
summarized
current
understanding
microbiota
CRC
outline
potential
translational
clinical
applications
diagnosis,
prevention,
treatment
CRC.
We
focused
reviewing
microbial
therapies
targeting
improve
efficacy
safety
chemotherapy
immunotherapy
for
identify
biomarkers
diagnosis
prognosis
Finally,
emphasized
obstacles
solutions
translating
knowledge
into
practice.
Gut Microbes,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Oct. 1, 2024
The
gut
microbiota
can
produce
a
variety
of
microbial-derived
metabolites
to
influence
tumor
development.
Tryptophan,
an
essential
amino
acid
in
the
human
body,
be
converted
by
microorganisms
via
indole
pathway
such
as
Indole-3-Lactic
Acid
(ILA),
Indole-3-Propionic
(IPA),
Indole
Acetic
(IAA)
and
Indole-3-Aldehyde
(IAld).
Recent
studies
have
shown
that
play
key
roles
progression,
they
used
adjuvant
regimens
for
immunotherapy
or
chemotherapy.
Here,
we
summarize
recent
findings
on
common
microbial
provide
review
mechanisms
different
microenvironment.
We
further
discuss
limitations
current
metabolite
research
future
possibilities.
It
is
expected
will
new
strategies
clinical
therapy.
Cancer Research,
Journal Year:
2024,
Volume and Issue:
84(6), P. 796 - 797
Published: Jan. 26, 2024
Abstract
Colorectal
cancer
is
a
prevalent
type
in
the
United
States,
affecting
both
genders
and
influenced
by
genetics
environmental
factors.
The
role
of
gut
microbiome
colorectal
development
therapy
response
burgeoning
field
study.
A
recent
study
uncovered
that
trans-3-indoleacrylic
acid
(IDA),
microbial
metabolite
from
P.
anaerobius,
promotes
inhibiting
ferroptosis,
nonapoptotic
cell
death
driven
unrestricted
lipid
peroxidation
subsequent
membrane
damage.
IDA
activates
aryl
hydrocarbon
receptor
(AHR),
nuclear
transcription
factor,
leading
to
expression
aldehyde
dehydrogenase
1
family
member
A3
(ALDH1A3).
ALDH1A3,
known
for
detoxification,
also
contributes
ferroptosis
resistance
generating
reduced
nicotinamide
adenine
dinucleotide
(NADH),
critical
synthesis
coenzyme
Q10
(COQH10),
apoptosis-inducing
factor
mitochondria-associated
2
(AIFM2,
as
FSP1).
Knocking
out
AHR,
AIFM2,
or
ALDH1A3
reverses
inhibitory
effect
on
IDA-mediated
tumor
growth.
Significantly,
anaerobius
enriched
patients
with
cancer,
supplementing
accelerates
progression
spontaneous
orthotopic
mouse
models.
Taken
together,
these
findings
suggest
targeting
anaerobius–mediated
emerges
promising
strategy
combat
development.
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
203, P. 107148 - 107148
Published: March 22, 2024
The
gut
microbiota,
known
as
the
"forgotten
organ"
and
"human
second
genome,"
comprises
a
complex
microecosystem.
It
significantly
influences
development
of
various
tumors,
including
colorectal,
liver,
stomach,
breast,
lung
cancers,
through
both
direct
indirect
mechanisms.
These
mechanisms
include
"gut-liver"
axis,
"lung-intestine"
interactions
with
immune
system.
intestinal
flora
exhibits
dual
roles
in
cancer,
promoting
suppressing
its
progression.
Traditional
Chinese
medicine
(TCM)
can
alter
cancer
progression
by
regulating
flora.
modifies
flora's
composition
structure,
along
levels
endogenous
metabolites,
thus
affecting
barrier,
system,
overall
body
metabolism.
actions
contribute
to
TCM's
significant
antitumor
effects.
Moreover,
microbiota
metabolizes
TCM
components,
enhancing
their
properties.
Therefore,
exploring
interaction
between
offers
novel
perspective
understanding
This
paper
succinctly
reviews
association
gastric,
cancers.
further
examines
current
research
on
flora,
focus
efficacy.
identifies
limitations
existing
studies
suggests
recommendations,
providing
insights
into
drug
effectiveness.
Additionally,
this
aims
guide
future
studies.
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
203, P. 107185 - 107185
Published: April 12, 2024
Microbes,
including
bacteria,
viruses,
fungi,
and
other
eukaryotic
organisms,
are
commonly
present
in
multiple
organs
of
the
human
body
contribute
significantly
to
both
physiological
pathological
processes.
Nowadays,
development
sequencing
technology
has
revealed
presence
composition
intratumoral
microbiota,
which
includes
Fusobacterium,
Bifidobacteria,
Bacteroides,
shed
light
on
significant
involvement
progression
colorectal
cancer
(CRC).
Here,
we
summarized
current
understanding
microbiota
CRC
outline
potential
translational
clinical
applications
diagnosis,
prevention,
treatment
CRC.
We
focused
reviewing
microbial
therapies
targeting
improve
efficacy
safety
chemotherapy
immunotherapy
for
identify
biomarkers
diagnosis
prognosis
Finally,
emphasized
obstacles
solutions
translating
knowledge
into
practice.
