Consequences of COVID-19 on Adipose Tissue Signatures DOI Open Access
Sontje Krupka, Anne Hoffmann, Mariami Jasaszwili

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2908 - 2908

Published: March 2, 2024

Since the emergence of coronavirus disease-19 (COVID-19) in 2019, it has been crucial to investigate causes severe cases, particularly higher rates hospitalization and mortality individuals with obesity. Previous findings suggest that adipocytes may play a role adverse COVID-19 outcomes people The impact vaccination infection on adipose tissue (AT) is currently unclear. We therefore analyzed 27 paired biopsies visceral subcutaneous AT from donors Leipzig Obesity BioBank have categorized into three groups (1: no infection/no vaccination; 2: but vaccinated; 3: infected vaccinated) based antibodies spike (indicating vaccination) and/or nucleocapsid proteins. provide additional insights biology through comprehensive histological transcriptome serum proteome analysis. This study demonstrates associated smaller average adipocyte size. gene expression was significantly more pronounced than mainly due immune system-related processes. Serum analysis revealed effects circulating adiponectin, interleukin 6 (IL-6), carbonic anhydrase 5A (CA5A), which are all related obesity blood glucose abnormalities.

Language: Английский

Adipose-tissue plasticity in health and disease DOI Creative Commons
Alexander P. Sakers, Mirian Krystel De Siqueira, Patrick Seale

et al.

Cell, Journal Year: 2022, Volume and Issue: 185(3), P. 419 - 446

Published: Feb. 1, 2022

Language: Английский

Citations

526
Inflammation in HIV and Its Impact on Atherosclerotic Cardiovascular Disease DOI

Laventa M. Obare,

Tecla M. Temu, S. Mallal

et al.

Circulation Research, Journal Year: 2024, Volume and Issue: 134(11), P. 1515 - 1545

Published: May 23, 2024

People living with HIV have a 1.5- to 2-fold increased risk of developing cardiovascular disease. Despite treatment highly effective antiretroviral therapy, people chronic inflammation that makes them susceptible multiple comorbidities. Several factors, including the reservoir, coinfections, clonal hematopoiesis indeterminate potential (CHIP), microbial translocation, and may contribute state inflammation. Within innate immune system, macrophages harbor latent are among prominent cells present in atheroma during progression atherosclerosis. They secrete inflammatory cytokines such as IL (interleukin)-6 tumor necrosis-α stimulate expression adhesion molecules on endothelium. This leads recruitment other cells, cluster differentiation (CD)8

Language: Английский

Citations

19
Adipose Tissue Remodeling in Pathophysiology DOI Creative Commons
Christopher Auger, Shingo Kajimura

Annual Review of Pathology Mechanisms of Disease, Journal Year: 2022, Volume and Issue: 18(1), P. 71 - 93

Published: Sept. 7, 2022

Rather than serving as a mere onlooker, adipose tissue is complex endocrine organ and active participant in disease initiation progression. Disruptions of biological processes operating within can disturb healthy systemic physiology, the sequelae which include metabolic disorders such obesity type 2 diabetes. A burgeoning interest field research has allowed for elucidation regulatory networks underlying both function dysfunction. Despite this progress, few diseases are treated by targeting maladaptation adipose, an oft-overlooked organ. In review, we elaborate on distinct subtypes adipocytes, their developmental origins secretory roles, dynamic interplay at work itself. Central to discussion relationship between states, including obesity, cachexia, infectious diseases, aim leverage our wealth knowledge development novel targeted therapeutics.

Language: Английский

Citations

65
Molecular and Cellular Bases of Lipodystrophy Syndromes DOI Creative Commons

Jamila Zammouri,

Camille Vatier, Émilie Capel

et al.

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 12

Published: Jan. 3, 2022

Lipodystrophy syndromes are rare diseases originating from a generalized or partial loss of adipose tissue. Adipose tissue dysfunction results heterogeneous genetic acquired causes, but leads to similar metabolic complications with insulin resistance, diabetes, hypertriglyceridemia, nonalcoholic fatty liver disease, dysfunctions the gonadotropic axis and endocrine defects leptin adiponectin deficiency. Diagnosis, based on clinical investigations, analyses, is major importance adapt medical care counseling. Molecular cellular bases these involve, among others, altered adipocyte differentiation, structure and/or regulation lipid droplet, premature senescence. frequently present as systemic multi-tissue involvement. After an update main molecular forms lipodystrophy, we will focus topics that have recently emerged in field. We discuss links between lipodystrophy ageing immuno-inflammatory aggressions tissue, well relationships lipomatosis lipodystrophy. Finally, indications substitutive therapy metreleptin, analog leptin, which approved Europe USA, be discussed.

Language: Английский

Citations

59
Weight Gain After HIV Therapy Initiation: Pathophysiology and Implications DOI Creative Commons
Nomathemba Chandiwana, Mark J. Siedner, Vincent C. Marconi

et al.

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 109(2), P. e478 - e487

Published: July 11, 2023

Abstract Rapid advances in the potency, safety, and availability of modern HIV antiretroviral therapy (ART) have yielded a near-normal life expectancy for most people living with (PLWH). Ironically, considering history HIV/AIDS (initially called “slim disease” because associated weight loss), latest dilemma faced by many starting is gain obesity, particularly Black people, women, those who commenced treatment advanced immunodeficiency. We review pathophysiology implications among PLWH on ART discuss why this phenomenon was recognized only recently, despite effective nearly 30 years. comprehensively explore theories causes, from initial speculation that simply return to health recovering wasting comparative effects newer regimens vs prior toxic agents, direct agents mitochondrial function. then ART, concomitant lipids, glucose metabolism, inflammatory markers. Finally, we intervention options limitations switching or specific within regimens, weight-gain mitigation strategies, potential hope access emerging antiobesity which are yet be evaluated population.

Language: Английский

Citations

30
Immuno-metabolic control of the balance between Th17-polarized and regulatory T-cells during HIV infection DOI
Alexis Yero, Ralph‐Sydney Mboumba Bouassa, Petronela Ancuța

et al.

Cytokine & Growth Factor Reviews, Journal Year: 2023, Volume and Issue: 69, P. 1 - 13

Published: Jan. 18, 2023

Language: Английский

Citations

27
Evolving mechanisms and presentations of cardiovascular disease in people with HIV: implications for management DOI
Ilana S. Nazari, Matthew J. Feinstein

Clinical Microbiology Reviews, Journal Year: 2024, Volume and Issue: 37(1)

Published: Feb. 1, 2024

People with HIV (PWH) are at elevated risk for cardiovascular diseases (CVDs), including myocardial infarction, heart failure, and sudden cardiac death, among other CVD manifestations. Chronic immune dysregulation resulting in persistent inflammation is common PWH, particularly those sustained viremia impaired CD4+ T cell recovery. This inflammatory milieu a major contributor to CVDs concert comorbidities (such as dyslipidemia smoking) and, lesser extent, off-target effects of antiretroviral therapy. In this review, we discuss the clinical mechanistic evidence surrounding heightened risks implications specific manifestations, practical guidance management setting evolving data.

Language: Английский

Citations

10
Update on regulation of GHRH and its actions on GH secretion in health and disease DOI
Antonio J. Montero‐Hidalgo, Mercedes del Río-Moreno, Jesús M. Pérez‐Gómez

et al.

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Language: Английский

Citations

1
Are New Antiretroviral Treatments Increasing the Risk of Weight Gain? DOI
Shahini Shah,

Laura Hindley,

Andrew Hill

et al.

Drugs, Journal Year: 2021, Volume and Issue: 81(3), P. 299 - 315

Published: Jan. 5, 2021

Language: Английский

Citations

42
Changes in Body Mass Index Over Time in People With and Without HIV Infection DOI Creative Commons
Jennifer O. Lam,

Wendy A. Leyden,

Stacey E. Alexeeff

et al.

Open Forum Infectious Diseases, Journal Year: 2024, Volume and Issue: 11(2)

Published: Feb. 1, 2024

Excess weight gain is an important health concern among people with HIV (PWH) on antiretroviral therapy (ART). The extent to which ART contributes body mass index (BMI) changes incompletely understood.

Language: Английский

Citations

6