MICROSCOPIC COLITIS: CONSIDERATIONS FOR GASTROENTEROLOGISTS, ENDOSCOPISTS, AND PATHOLOGISTS DOI Creative Commons
Lorete Maria da Silva Kotze, Paulo Gustavo Kotze, Luiz Roberto Kotze

et al.

Arquivos de Gastroenterologia, Journal Year: 2023, Volume and Issue: 60(2), P. 188 - 193

Published: June 1, 2023

ABSTRACT Microscopic colitis is a chronic inflammatory bowel disease characterized by non-bloody diarrhea that can range from mild to severe. It difficult attribute up 10-20% of microscopic colitis. The three determinants factors the diagnosis are characteristic clinical symptoms, normal endoscopic picture colon, and pathognomonic histological picture. This manuscript aimed update considerations recommendations for professionals involved (gastroenterologist, endoscopists pathologist) in MC. In addition, short recommendation about treatment.

Language: Английский

Celiac Disease–Related Conditions: Who to Test? DOI Creative Commons
Fabiana Zingone,

Julio C. Bai,

Christophe Cellier

et al.

Gastroenterology, Journal Year: 2024, Volume and Issue: 167(1), P. 64 - 78

Published: March 7, 2024

Celiac disease (CeD) is a chronic immune-mediated condition triggered by gluten consumption in genetically predisposed individuals. Approximately 1% of the general population affected disorder. Disease presentation heterogeneous and, despite growing awareness among physicians and public, it continues to be underestimated. The most effective strategy for identifying undiagnosed CeD proactive case finding through serologic testing high-risk groups. We reviewed recent evidence on association between more than 20 conditions. In light this review, screening recommended individuals with (1) autoimmune accompanying symptoms suggestive CeD; (2) diseases that may mimic (eg, irritable bowel syndrome [IBS], inflammatory [IBD], microscopic colitis); (3) patients conditions high prevalence: first-degree relatives, idiopathic pancreatitis, unexplained liver enzyme abnormalities, hepatitis, primary biliary cholangitis, hyposplenism or functional asplenia severe bacterial infection, type 1 diabetes mellitus, Hashimoto's thyroiditis Graves' disease, Sjögren's syndrome, dermatitis herpetiformis, recurrent aphthous enamel defects, ataxia, peripheral neuropathy, delayed menarche premature menopause, Down Turner Williams fatigue IgA nephropathy, deficiency. serology should initial step process. However, any aforementioned disorders who are undergoing upper endoscopy, biopsies performed rule out CeD.

Language: Английский

Citations

23
Hypoxia and Intestinal Inflammation: Common Molecular Mechanisms and Signaling Pathways DOI Open Access
Kristina A. Dvornikova, Olga N. Platonova, E. Yu. Bystrova

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2425 - 2425

Published: Jan. 26, 2023

The gastrointestinal tract (GI) has a unique oxygenation profile. It should be noted that the state of hypoxia can characteristic both normal and pathological conditions. Hypoxia-inducible factors (HIF) play key role in mediating response to hypoxia, they are tightly regulated by group enzymes called HIF prolyl hydroxylases (PHD). In this review, we discuss involvement inflammation signaling pathways pathogenesis inflammatory bowel disease (IBD) elaborate detail on multiple immune reactions during intestinal inflammation. We emphasize critical influence tissue microenvironment highlight existence overlapping functions responses mediated same molecular mechanisms. Finally, also provide an update development corresponding therapeutic approaches would useful for treatment or prophylaxis disease.

Language: Английский

Citations

24
Celiac disease and risk of microscopic colitis: A nationwide population‐based matched cohort study DOI Creative Commons
David Bergman, Hamed Khalili, Benjamin Lebwohl

et al.

United European Gastroenterology Journal, Journal Year: 2023, Volume and Issue: 11(2), P. 189 - 201

Published: March 1, 2023

An association has been reported between celiac disease (CD) and microscopic colitis (MC). However, large, population-based cohort studies are rare.To systematically examine the CD MC in a nationwide cohort.We conducted matched study Sweden of 45,138 patients with biopsy-verified (diagnosed 1990-2016), 223,149 reference individuals, 51,449 siblings patients. Data on were obtained from all (n = 28) pathology departments Sweden. Adjusted hazard ratios (aHRs) calculated using Cox regression.During follow-up, 452 197 individuals received an diagnosis (86.1 vs. 7.5 per 100,000 person-years). This difference corresponded to aHR 11.6 (95% confidence interval [CI] 9.8-13.8) or eight extra cases 1000 followed up for 10 years. Although risk was highest during first year follow-up (aHR 35.2; 95% CI 20.1-61.6), it remained elevated even after years 8.1; 6.0-10.9). Examining subtypes lymphocytic (LC) collagenous (CC) separately, 12.4 10.0-15.3) LC 10.2 7.7-13.6) CC. also more common before (adjusted odds ratio [aOR] 52.7; 31.4-88.4). Compared siblings, estimates decreased but (CD later MC: HR 6.2; earlier aOR 7.9).Our demonstrated very strong increased future previous The magnitude associations underscores need consider concomitance these diagnoses which gastrointestinal symptoms persist recur despite gluten-free diet conventional treatment. comparatively lower sibling comparisons suggest that shared genetic early environmental factors may contribute MC.

Language: Английский

Citations

14
Association between frailty and chronic constipation and chronic diarrhea among American older adults: National Health and Nutrition Examination Survey DOI Creative Commons

Xuna Liu,

Yiwen Wang, Lin Shen

et al.

BMC Geriatrics, Journal Year: 2023, Volume and Issue: 23(1)

Published: Nov. 15, 2023

Abstract Background This study was to explore the relationship between chronic constipation, diarrhea, and frailty in older Americans. Methods cross-sectional selected a total of 4241 community-dwelling individuals aged 60 years from 2005–2010 National Health Nutrition Examination Survey. Frailty measured using 49-item index, index > 0.21 defined as frail status. Chronic constipation diarrhea were “usual or most common type stool” by Bristol Stool Form Scale (BSFS) Types 1 2 BSFS 6 7, respectively. Weighted logistic regression analysis used examine gut health Restricted cubic spline (RCS) curves built assess association stool frequency. Results status associated with higher odds an unadjusted model; however, after further adjusting for confounding variables, not statistically significant. We discovered positive correlation adjustment all variables. The showed U-shaped frequency, smallest at frequency 10 stools/week. Conclusion Negative associations observed among adults. Older adults who have bowel movement about times per week are least frail. Future studies warranted confirm causal this association.

Language: Английский

Citations

14
Therapeutic potential of seaweed extracts: In vitro and in vivo studies on alleviating inflammation and enhancing intestinal barrier function. DOI
Yu Rim Kim, Soo Yeon Park, Ji Yeon Kim

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 59, P. 103774 - 103774

Published: March 4, 2024

Language: Английский

Citations

5
Patients With Microscopic Colitis Are at Higher Risk of Major Adverse Cardiovascular Events: A Matched Cohort Study DOI Creative Commons
Anders Forss, David Bergman, Björn Roelstraete

et al.

Clinical Gastroenterology and Hepatology, Journal Year: 2023, Volume and Issue: 21(13), P. 3356 - 3364.e9

Published: May 26, 2023

Inflammatory diseases are associated with an increased risk of incident major adverse cardiovascular events (MACE). However, data on MACE lacking in large population-based histopathology cohorts microscopic colitis (MC).

Language: Английский

Citations

12
Immune‐mediated inflammatory diseases of the gastrointestinal tract: Beyond Crohn's disease and ulcerative colitis DOI Creative Commons
Sudheer K. Vuyyuru, Saurabh Kedia, Pabitra Sahu

et al.

JGH Open, Journal Year: 2022, Volume and Issue: 6(2), P. 100 - 111

Published: Jan. 20, 2022

Immune-mediated inflammatory diseases (IMIDs) are a diverse group of complex that result from dysregulated immune pathways and can involve any system the human body. Inflammatory bowel disease (IBD) is one such involving gastrointestinal (GI) system. With high prevalence in West increasing incidence newly industrialized countries, IBD poses significant burden on health care. IMIDs GI other than have similar clinical features, causing diagnostic therapeutic challenges. Although these disorders share common pathophysiology, defects occur anywhere network cytokines, mediators, innate adaptive systems, leading to unregulated inflammation. Precise knowledge about them will help determine possible targeted therapy. Thus, it essential distinguish IBD. This review describes various tract mimic

Language: Английский

Citations

19
MODERN APPROACHES TO RECOGNITION AND MANAGEMENT OF MICROSCOPIC COLITIS DOI

O. M. Kulchytska,

N. V. Kuzmіnova,

S. E. Lozynsky

et al.

World of Medicine and Biology, Journal Year: 2025, Volume and Issue: 20(90), P. 253 - 253

Published: Jan. 1, 2025

Language: Английский

Citations

0
Clinical features, treatment, and prognosis of secukinumab-induced inflammatory bowel disease DOI Creative Commons
Ronghui Li,

Haibo Lei,

Chunjiang Wang

et al.

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: Jan. 19, 2025

Inflammatory bowel disease (IBD) is a rare adverse effect linked to secukinumab, with limited clinical data available. This study aimed analyze the features of secukinumab-induced IBD and offer recommendations for careful administration secukinumab. We conducted retrospective analysis by gathering case reports series through database search, collected until September 30, 2024. A total forty patients (21 males 19 females) fulfilled inclusion criteria, median age 42 years (range 19, 70). The time onset was 4 months following initial dose 0.25, 53). most common symptoms reported were abdominal pain (60.0%), diarrhea (37.5%), bloody (32.5%), fever (30.0%). Colonoscopy findings predominantly showed ulcers (62.5%) inflammation (27.5%). Biopsy results revealed crypt microabscesses (22.5%), cryptitis (20.0%), inflammatory cellular infiltrates both acute chronic (22.5%). After discontinuation symptom relief treatment systemic steroids targeted therapies (52.5%), mesalamine Comprehensive screenings are essential prior initiating secukinumab therapy. Gastrointestinal necessitate close monitoring during treatment. Upon diagnosis IBD, should be discontinued, steroid therapy initiated. Patients who do not respond or experience relapse considered immunosuppressive

Language: Английский

Citations

0
Epidemiology, clinical presentation, associated factors, and current trends in microscopic colitis DOI Open Access
Renata R. Savzikhanova, Dilyara G. Iskhakova, Е. В. Хазова

et al.

Kazan medical journal, Journal Year: 2025, Volume and Issue: 106(1), P. 117 - 128

Published: March 19, 2025

Microscopic colitis has attracted the attention of internists and gastroenterologists due to its increasing incidence gaps in knowledge about disease. Like other inflammatory bowel diseases, microscopic frequently manifests as watery diarrhea, particularly older patients, significantly reduces their quality life. This review aims analyze current understanding based on published studies. A literature search was conducted PubMed eLibrary.Ru (1976–2024) databases using keywords микроскопический колит. Epidemiological data indicate an with global prevalence variability. The present study examines risk factors for colitis, including gut microbiota alterations, genetic determinants, infectious factors, well association disease COVID-19. Significant include smoking certain medications. discusses sex- age-related characteristics differentiation between collagenous lymphocytic subtypes. According most studies, developing is associated female sex age. notably higher among women than men. histological criteria, clinical presentation, differential diagnosis are outlined, along diagnostic criteria incomplete forms In addition, non-invasive biomarkers associations diseases systems, autoimmune cardiovascular conditions. Of particular interest frequent coexistence celiac Gaps analyzed, issues management, achieving maintaining remission, addressed. summarizes evidence a cause unexplained those countries low reported prevalence.

Language: Английский

Citations

0