Bacteria in cancer initiation, promotion and progression

Nature reviews. Cancer, Journal Year: 2023, Volume and Issue: 23(9), P. 600 - 618

Published: July 3, 2023

Language: Английский

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Global, regional, and national lifetime risks of developing and dying from gastrointestinal cancers in 185 countries: a population-based systematic analysis of GLOBOCAN

˜The œLancet. Gastroenterology & hepatology, Journal Year: 2024, Volume and Issue: 9(3), P. 229 - 237

Published: Jan. 4, 2024

Background Gastrointestinal cancers account for a quarter of the global cancer incidence and third cancer-related deaths. We sought to estimate lifetime risks developing dying from gastrointestinal at country, world region, levels in 2020. Methods For this population-based systematic analysis, we obtained estimates mortality rates GLOBOCAN 185 countries, alongside all-cause population data UN. Countries were categorised into quartiles Human Development Index (HDI). The risk was estimated with standard method that adjusts multiple primaries, taking competing death causes other than life expectancy. Findings birth 8·20% (95% CI 8·18–8·21) 6·17% (6·16–6·18) men, 9·53% 9·51–9·55) them 7·23% (7·22–7·25); women, 6·84% (6·82–6·85) 5·09% (5·08–5·10). Colorectal presented highest risk, accounting 38·5% total developing, 28·2% from, cancers, followed by stomach, liver, oesophagus, pancreas, gallbladder. Eastern Asia has gallbladder, Australia New Zealand colorectal cancer, Western Europe pancreatic cancer. increased consistently increasing level HDI; however, high HDI countries (the quartile) had risk. Interpretation translates one 12 people 16 cancers. identified observed disparities across counties warrants context-specific targeted control health systems planning. Funding Beijing Nova Program, CAMS Innovation Fund Medical Sciences, Talent Incentive Program Cancer Hospital, (Hope Star).

Language: Английский

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Gallbladder cancer: current and future treatment options

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: May 11, 2023

Surgery remains the preferred treatment option for early-stage gallbladder cancer (GBC). According to anatomical position of primary tumor, accurate preoperative stage and strict control surgical indications, appropriate strategies are selected achieve optimal effect. However, most patients have already been at locally advanced or tumor has metastasized initial diagnosis. The postoperative recurrence rate 5-year survival remain unsatisfactory even after radical resection cancer. Hence, there is an urgent need more options, such as neoadjuvant therapy, adjuvant therapy first-line second-line treatments local progression metastasis, in whole-course management patients. In recent years, application molecular targeted drugs immunotherapy brought greater hope broader prospects cancer, but their effects improving prognosis still lack sufficient evidence-based medicine evidence, so many problems should be addressed by further research. Based on latest progress research, this review systematically analyzes trends

Language: Английский

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Interpretation, Reporting, Imaging-Based Workups, and Surveillance of Incidentally Detected Gallbladder Polyps and Gallbladder Wall Thickening: 2025 Recommendations From the Korean Society of Abdominal Radiology

Korean Journal of Radiology, Journal Year: 2025, Volume and Issue: 26(2), P. 102 - 102

Published: Jan. 1, 2025

Incidentally detected gallbladder polyps (GBPs) and wall thickening (GBWT) are frequently encountered in clinical practice. However, characterizing GBPs GBWT asymptomatic patients can be challenging may result overtreatment, including unnecessary follow-ups or surgeries. The Korean Society of Abdominal Radiology (KSAR) Clinical Practice Guideline Committee has developed expert recommendations that focus on standardized imaging interpretation follow-up strategies for both GBWT, with support from the KSAR. These guidelines, which address 24 key questions, aim to standardize approach findings, reporting, imaging-based workups, surveillance incidentally GBWT. This recommendation promotes evidence-based practice, facilitates communication between radiologists referring physicians, reduces interventions.

Language: Английский

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Surgical outcomes of gallbladder cancer: the OMEGA retrospective, multicentre, international cohort study

EClinicalMedicine, Journal Year: 2023, Volume and Issue: 59, P. 101951 - 101951

Published: April 13, 2023

Language: Английский

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YKL-40 derived from infiltrating macrophages cooperates with GDF15 to establish an immune suppressive microenvironment in gallbladder cancer

Cancer Letters, Journal Year: 2023, Volume and Issue: 563, P. 216184 - 216184

Published: April 23, 2023

Language: Английский

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Global, regional, and national burden and trends analysis of gallbladder and biliary tract cancer from 1990 to 2019 and predictions to 2030: a systematic analysis for the Global Burden of Disease Study 2019

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: April 4, 2024

Objectives Our aim was to explore the disease burden caused by gallbladder and biliary tract cancer globally, regionally, nationally, age sex. Methods The absolute number of cases age-standardized rates (ASR) incidence, prevalence, mortality, disability-adjusted life years (DALYs) due were extracted from Global Burden Disease (GBD) Study 2019. We estimated trends in calculating percentage change annual (EAPC) ASR, social development index (SDI), region, nation, sex, age. Results From 1990 2019, incident cases, prevalent deaths, DALYs worldwide significantly increased 1.85-fold, 1.92-fold, 1.82-fold, 1.68-fold, respectively. However, tend decrease globally over time. Nevertheless, heterogeneous patterns exist between geographic regions different geographical risk factors, distinct epidemiologically predominant subtypes, potential genetic predispositions or ethnicity. Additionally, socioeconomic status mediates regional variation burden, with increasing SDI HDI scores associated downward DALYs. Older individuals females are at higher cancer, but early-onset is a cause for concern, especially those living lower areas males. High BMI primary factors underlying accounted 15.2% deaths 15.7% Conclusion study comprehensively elucidated distribution dynamic past three decades, multiple dimensions. These findings emphasize importance promoting healthy lifestyle as population-level prevention strategy tailoring control actions based on localized epidemic profiles anatomical subtype.

Language: Английский

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Compressive stresses in cancer: characterization and implications for tumour progression and treatment

Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: 24(11), P. 768 - 791

Published: Oct. 10, 2024

Language: Английский

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The causal relationship between gut microbiota and biliary tract cancer: comprehensive bidirectional Mendelian randomization analysis

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: March 15, 2024

Background Growing evidence has shown that gut microbiome composition is associated with Biliary tract cancer (BTC), but the causality remains unknown. This study aimed to explore causal relationship between microbiota and BTC, conduct an appraisal of microbiome’s utility in facilitating early diagnosis BTC. Methods We acquired summary data for Genome-wide Association Studies (GWAS) pertaining BTC (418 cases 159,201 controls) from Biobank Japan (BBJ) database. Additionally, GWAS relevant (N = 18,340) were sourced MiBioGen consortium. The primary methodology employed analysis consisted Inverse Variance Weighting (IVW). Evaluations sensitivity carried out through utilization multiple statistical techniques, encompassing Cochrane’s Q test, MR-Egger intercept evaluation, global test MR-PRESSO, a leave-one-out methodological analysis. Ultimately, reverse Mendelian Randomization was conducted assess potential reciprocal causality. Results outcomes derived IVW substantiated presence Family Streptococcaceae (OR 0.44, P 0.034), Veillonellaceae 0.46, 0.018), Genus Dorea 0.29, 0.041) exerted protective influence against Conversely, Class Lentisphaeria 2.21, 0.017), Lachnospiraceae FCS020 Group 2.30, 0.013), Order Victivallales 0.017) adverse impact. To any effect, we used as exposure outcome, this revealed associations five different types microbiota. disclosed absence empirical indicators either heterogeneity or pleiotropy. Conclusion investigation represents inaugural identification indicative supporting beneficial detrimental relationships risk determined MR methodologies. These could hold significance formulation individualized therapeutic strategies at prevention survival enhancement.

Language: Английский

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Projected Incidence of Hepatobiliary Cancers and Trends Based on Age, Race, and Gender in the United States

Cancers, Journal Year: 2024, Volume and Issue: 16(4), P. 684 - 684

Published: Feb. 6, 2024

Identifying the projected incidence of hepatobiliary cancers and recognizing patient cohorts at increased risk can help develop targeted interventions resource allocation. The expected subtypes in different age groups, races, genders remains unknown. Historical epidemiological data from Surveillance, Epidemiology, End Results (SEER) database was used to project future malignancies United States identify trends by age, race, gender. Patients ≥18 years diagnosed with a malignancy between 2001 2017 were included. US Census Bureau National Population projects provided population 2029. Age-Period-Cohort forecasting model estimate births cohort-specific incidence. All analyses completed using R Statistical Software. We included 110381 historical patients following subtypes: hepatocellular cancer (HCC) (68%), intrahepatic cholangiocarcinoma (iCCA) (11.5%), gallbladder (GC) (8%), extrahepatic (eCCA) (7.6%), ampullary (AC) (4%). Our models predict HCC double (2001 2029) 4.5 9.03 per 100,000, most significant increase anticipated 70-79 age. In contrast, is continue decline among Asian population. Incidence iCCA increase, especially white population, rates 2029 those (2.13 vs. 0.88 respectively; p < 0.001). GC black increase. eCCA significantly Hispanic while that AC will remain stable. overall coming years, certain groups risk. These findings may allocation when considering screening, treatment, research years.

Language: Английский

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