Therapeutic peptides: current applications and future directions

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Feb. 14, 2022

Abstract Peptide drug development has made great progress in the last decade thanks to new production, modification, and analytic technologies. Peptides have been produced modified using both chemical biological methods, together with novel design delivery strategies, which helped overcome inherent drawbacks of peptides allowed continued advancement this field. A wide variety natural obtained studied, covering multiple therapeutic areas. This review summarizes efforts achievements peptide discovery, their current applications. We also discuss value challenges associated future developments peptides.

Language: Английский

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Therapeutic strategies for COVID-19: progress and lessons learned

Nature Reviews Drug Discovery, Journal Year: 2023, Volume and Issue: 22(6), P. 449 - 475

Published: April 19, 2023

Language: Английский

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Cyclic Peptides for Drug Development

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 63(3)

Published: Oct. 23, 2023

Abstract Cyclic peptides are fascinating molecules abundantly found in nature and exploited as molecular format for drug development well other applications, ranging from research tools to food additives. Advances peptide technologies made over many years through improved methods synthesis have resulted a steady stream of new drugs, with an average around one cyclic approved per year. Powerful screening random libraries, de novo generating ligands, enabled the drugs independent naturally derived now offer virtually unlimited opportunities. In this review, we feature therapeutically relevant discuss unique properties peptides, enormous technological advances ligand recent years, current challenges opportunities developing that address unmet medical needs.

Language: Английский

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Macrocyclization strategies for cyclic peptides and peptidomimetics

RSC Medicinal Chemistry, Journal Year: 2021, Volume and Issue: 12(8), P. 1325 - 1351

Published: Jan. 1, 2021

Macrocyclization between head, tail or sidechains is a frequently employed strategy to enhance peptide and peptidomimetic stability, selectivity affinity.

Language: Английский

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Sustainability in peptide chemistry: current synthesis and purification technologies and future challenges

Green Chemistry, Journal Year: 2022, Volume and Issue: 24(3), P. 975 - 1020

Published: Jan. 1, 2022

Developing greener synthesis processes is an inescapable necessity to transform the industrial landscape, mainly in pharmaceutical sector, into a long-term, sustainable reality.

Language: Английский

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Identification of potent antimicrobial peptides via a machine-learning pipeline that mines the entire space of peptide sequences

Nature Biomedical Engineering, Journal Year: 2023, Volume and Issue: 7(6), P. 797 - 810

Published: Jan. 12, 2023

Language: Английский

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Strategies for Improving Peptide Stability and Delivery

Pharmaceuticals, Journal Year: 2022, Volume and Issue: 15(10), P. 1283 - 1283

Published: Oct. 19, 2022

Peptides play an important role in many fields, including immunology, medical diagnostics, and drug discovery, due to their high specificity positive safety profile. However, for delivery as active pharmaceutical ingredients, vectors, or diagnostic imaging molecules, they suffer from two serious shortcomings: poor metabolic stability short half-life. Major research efforts are being invested tackle those drawbacks, where structural modifications novel tactics have been developed boost ability reach targets fully functional species. The benefit of selected technologies enhancing the resistance peptides against enzymatic degradation pathways maximizing therapeutic impact also reviewed. Special note cell-penetrating well stapled modified peptides, which demonstrated superior parent reported.

Language: Английский

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ToxIBTL: prediction of peptide toxicity based on information bottleneck and transfer learning

Bioinformatics, Journal Year: 2022, Volume and Issue: 38(6), P. 1514 - 1524

Published: Jan. 4, 2022

Abstract Motivation Recently, peptides have emerged as a promising class of pharmaceuticals for various diseases treatment poised between traditional small molecule drugs and therapeutic proteins. However, one the key bottlenecks preventing them from is their toxicity toward human cells, few available algorithms predicting are specially designed short-length peptides. Results We present ToxIBTL, novel deep learning framework by utilizing information bottleneck principle transfer to predict well Specifically, we use evolutionary physicochemical properties peptide sequences integrate into feature representation scheme, which relevant retained redundant minimized in obtained features. Moreover, introduced common knowledge contained proteins peptides, aims improve capability. Extensive experimental results demonstrate that ToxIBTL not only achieves higher prediction performance than state-of-the-art methods on dataset, but also has competitive protein dataset. Furthermore, user-friendly online web server established implementation proposed ToxIBTL. Availability The data can be freely accessible at http://server.wei-group.net/ToxIBTL. Our source code https://github.com/WLYLab/ToxIBTL. Supplementary Bioinformatics online.

Language: Английский

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Accurate de novo design of membrane-traversing macrocycles

Cell, Journal Year: 2022, Volume and Issue: 185(19), P. 3520 - 3532.e26

Published: Aug. 29, 2022

We use computational design coupled with experimental characterization to systematically investigate the principles for macrocycle membrane permeability and oral bioavailability. designed 184 6–12 residue macrocycles a wide range of predicted structures containing noncanonical backbone modifications experimentally determined 35; 29 are very close models. With such control, we show that can be achieved by ensuring all amide (NH) groups engaged in internal hydrogen bonding interactions. 84 designs over size cross membranes an apparent greater than 1 × 10−6 cm/s. Designs exposed NH made permeable through alternative isoenergetic fully hydrogen-bonded state favored lipid membrane. The ability robustly membrane-permeable orally bioavailable peptides high structural accuracy should contribute next generation therapeutics.

Language: Английский

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Alternative therapeutic strategies to treat antibiotic-resistant pathogens

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 22(5), P. 262 - 275

Published: Dec. 11, 2023

Language: Английский

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