Antioxidant Therapy in Cancer: Rationale and Progress

Antioxidants, Journal Year: 2022, Volume and Issue: 11(6), P. 1128 - 1128

Published: June 8, 2022

Cancer is characterized by increased oxidative stress, an imbalance between reactive oxygen species (ROS) and antioxidants. Enhanced ROS accumulation, as a result of metabolic disturbances signaling aberrations, can promote carcinogenesis malignant progression inducing gene mutations activating pro-oncogenic signaling, providing possible rationale for targeting stress in cancer treatment. While numerous antioxidants have demonstrated therapeutic potential, their clinical efficacy remains unproven. Here, we review the for, recent advances in, pre-clinical research on antioxidant therapy cancer, including with nonenzymatic antioxidants, such NRF2 activators, vitamins, N-acetylcysteine GSH esters, or enzymatic NOX inhibitors SOD mimics. In addition, will offer insights into prospective options improving effectiveness therapy, which may expand its applications

Language: Английский

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Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: March 14, 2023

Doxorubicin (DOX) is a powerful and commonly used chemotherapeutic drug, alone or in combination variety of cancers, while it has been found to cause serious cardiac side effects clinical application. More more researchers are trying explore the molecular mechanisms DOX-induced cardiomyopathy (DIC), which oxidative stress inflammation considered play significant role. This review summarizes signaling pathways related DIC compounds that exert cardioprotective by acting on relevant pathways, including role Nrf2/Keap1/ARE, Sirt1/p66Shc, Sirt1/PPAR/PGC-1α NOS, NOX, Fe2+ stress, as well NLRP3/caspase-1/GSDMD, HMGB1/TLR4/MAPKs/NF-κB, mTOR/TFEB/NF-κB inflammation. Hence, we attempt explain terms inflammation, provide theoretical basis new idea for further drug research reducing DIC. Video Abstract.

Language: Английский

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To metabolomics and beyond: a technological portfolio to investigate cancer metabolism

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: March 22, 2023

Abstract Tumour cells have exquisite flexibility in reprogramming their metabolism order to support tumour initiation, progression, metastasis and resistance therapies. These reprogrammed activities include a complete rewiring of the bioenergetic, biosynthetic redox status sustain increased energetic demand cells. Over last decades, cancer field has seen an explosion new biochemical technologies giving more tools than ever before navigate this complexity. Within cell or tissue, metabolites constitute direct signature molecular phenotype thus profiling concrete clinical applications oncology. Metabolomics fluxomics, are key technological approaches that mainly revolutionized enabling researchers both qualitative mechanistic model cancer. Furthermore, upgrade from bulk single-cell analysis provided unprecedented opportunity investigate biology at cellular resolution allowing depth quantitative complex heterogenous diseases. More recently, advent functional genomic screening allowed identification pathways, processes, biomarkers novel therapeutic targets concert with other allow patient stratification treatment regimens. This review is intended be guide for metabolism, highlighting current emerging technologies, emphasizing advantages, disadvantages potential leading development innovative anti-cancer

Language: Английский

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Eighteen Novel Bioactive Peptides from Monkfish (Lophius litulon) Swim Bladders: Production, Identification, Antioxidant Activity, and Stability

Marine Drugs, Journal Year: 2023, Volume and Issue: 21(3), P. 169 - 169

Published: March 7, 2023

In the study, papain was chosen from five proteases to hydrolyze proteins of monkfish swim bladders for effectively utilizing (Lophius litulon) processing byproducts, and hydrolysis conditions were optimized as temperature 65 °C, pH 7.5, enzyme dose 2.5% time 5 h using single-factor orthogonal experiments. Eighteen peptides purified bladder hydrolysate by ultrafiltration gel permeation chromatography methods identified YDYD, QDYD, AGPAS, GPGPHGPSGP, GPK, HRE, GRW, ARW, GPTE, DDGGK, IGPAS, AKPAT, YPAGP, DPT, FPGPT, GPGPT, GPT DPAGP, respectively. Among eighteen peptides, GRW ARW showed significant DPPH· scavenging activities with EC50 values 1.053 ± 0.003 0.773 mg/mL, respectively; YPAGP revealed significantly HO· 0.150 0.060, 0.177 0.035, 0.201 0.013, 0.183 0.0016 0.190 0.010 DDGGK have O2-· capability 0.126 0.0005, 0.112 0.0028, 0.127 0.0002, 0.128 0.0018 0.107 0.0002 QDYD strong ABTS+· ability 3.197 0.036, 2.337 0.016 3.839 0.102 displayed remarkable lipid peroxidation inhibition Ferric-reducing antioxidant properties. Moreover, YDYD can protect Plasmid DNA HepG2 cells against H2O2-induced oxidative stress. Furthermore, isolated had high stability under temperatures ranging 25-100 °C; more sensitive alkali treatment, but acid treatment; treated simulated GI digestion. Therefore, prepared especially could serve functional components applied in health-promoting products because their high-antioxidant functions.

Language: Английский

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A systematic review of natural products for skin applications: Targeting inflammation, wound healing, and photo-aging

Phytomedicine, Journal Year: 2023, Volume and Issue: 115, P. 154824 - 154824

Published: April 19, 2023

Every day the skin is constantly exposed to several harmful factors that induce oxidative stress. When cells are incapable maintain balance between antioxidant defenses and reactive oxygen species, no longer can keep its integrity homeostasis. Chronic inflammation, premature aging, tissue damage, immunosuppression possible consequences induced by sustained exposure environmental endogenous species. Skin immune non-immune together with microbiome essential efficiently trigger responses For this reason, an ever-increasing demand for novel molecules capable of modulating functions in has risen level their development, particularly field natural product-derived molecules. In review, we explore different classes showed evidence modulate responses, as well target receptors signaling pathways. Moreover, describe role polyphenols, polysaccharides, fatty acids, peptides, probiotics treatments conditions, including wound healing, infection, allergies, aging. Literature was searched, analyzed, collected using databases, PubMed, Science Direct, Google Scholar. The search terms used included "Skin", "wound healing", "natural products", "skin microbiome", "immunomodulation", "anti-inflammatory", "antioxidant", "infection", "UV radiation", "polyphenols", "polysaccharides", "fatty acids", "plant oils", "peptides", "antimicrobial peptides", "probiotics", "atopic dermatitis", "psoriasis", "auto-immunity", "dry skin", "aging", etc., combinations these keywords. Natural products offer solutions conditions. Significant anti-inflammatory activities were reported, followed ability skin. Several membrane-bound recognize diverse types natural-derived molecules, promoting improve Despite increasing progress drug discovery, limiting need future clarification. Understanding safety, biological activities, precise mechanisms action a priority characterization active compounds responsible that. This review provides directions studies development new important pharmaceutical cosmeceutical value.

Language: Английский

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