Trends in cancer, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Cancer Cell, Journal Year: 2024, Volume and Issue: 42(11), P. 1825 - 1863
Published: Oct. 10, 2024
Language: Английский
Citations
57
Nature Nanotechnology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 3, 2025
Language: Английский
Citations
2
Cellular and Molecular Immunology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 10, 2024
While immunotherapy with immune checkpoint inhibitors (ICIs) has revolutionized the clinical management of various malignancies, a large fraction patients are refractory to ICIs employed as standalone therapeutics, necessitating development combinatorial treatment strategies. Immunogenic cell death (ICD) inducers have attracted considerable interest partners for ICIs, at least in part owing their ability initiate tumor-targeting adaptive response. However, compared either approach alone, regimens involving ICD and not always shown superior activity. Here, we discuss accumulating evidence on therapeutic interactions between oncological settings, identify key factors that may explain discrepancies preclinical findings, propose strategies address existing challenges increase efficacy these combinations cancer.
Language: Английский
Citations
8
ACS Nano, Journal Year: 2025, Volume and Issue: 19(1), P. 488 - 503
Published: Jan. 4, 2025
The concept of immunogenic cell death (ICD) induced by chemotherapy as a potential synergistic modality for cancer immunotherapy has been widely discussed. Unfortunately, most chemotherapeutic agents failed to dictate effective ICD responses due their defects in inducing potent signaling. Here, we report dual-enzyme-instructed peptide self-assembly platform CPMC (CPT-GFFpY-PLGVRK-Caps) that cooperatively utilizes camptothecin (CPT) and capsaicin (Caps) promote engage systemic adaptive immunity tumor rejection. Although CPT Caps respectively prevent progression inhibiting type-I DNA topoisomerase activating transient receptor cation channel subfamily V member 1 (TRPV1) intracellular calcium overload, neither alone effectively stimulates sufficient signaling meet immunotherapeutic needs. CPMC, sequentially allowing an active derivative VRK-Caps release extracellularly intracellularly, can synergize two distinct apoptosis pathways stimulated increase immunogenicity elicit T-cell-based immunity. Consequently, facilitates the generation improved tumor-specific cytotoxic T-cell sustained immunological memory, successfully suppressing both primary distant tumors. Moreover, render tumors susceptible PD-L1 blockade with antiprogrammed death-ligand (aPDL1) antibody inhibition. Combining drugs low ICD-stimulating capacity using strategy was demonstrated boost potentiate immunotherapy.
Language: Английский
Citations
1
Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: Jan. 28, 2025
Tumor microenvironment (TME), particularly immune cell infiltration, programmed death (PCD) and stress, has increasingly become a focal point in colorectal cancer (CRC) treatment. Uncovering the intricate crosstalk between these factors can enhance our understanding of CRC, guide therapeutic strategies, improve patient prognosis. We constructed an immune-related stress (ICDS) prognostic model utilizing machine learning methodologies. Furthermore, we performed enrichment analyses deconvolution algorithms to elucidate complex interactions infiltration processes PCD within substantial array transcriptomic data from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus base (GEO) related CRC. Single-cell sequencing biochemical experiments were used validate interaction genes tumor cells. ICDS exhibited robust predictive performance seven independent cohorts, revealing inverse correlation scores Meanwhile, index was positively correlated with clinical stage. Model analysis indicated that subgroups low heightened activation features elevated activity pathways. further revealed macrophages central drivers characteristics underlying differences model. Pseudotime cellular gene GAL3ST4 promotes transition toward M2 pro-tumor phenotype. communication experimental validation cuproptosis cells suppress expression, thereby inhibiting M2-like macrophage polarization. In summary, uncovered mechanism by which downregulate expression via inhibit polarization, providing new targets biomarkers for CRC treatment prognosis evaluation.
Language: Английский
Citations
1
Photochemical & Photobiological Sciences, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 19, 2025
Abstract In this perspective, we present and discuss pre-clinical some clinical studies demonstrating that local photodynamic therapy (PDT) per se is a treatment modality can induce systemic anti-tumour immunity, however, the efficacy strongly enhanced when PDT combined with other modalities, e.g., vaccines or ICI therapy. has been recognized for over 30 years as inducing strong immune effects in treated tumours. More recently, become perceived distinct type of immunogenic antitumor an attractive potential use unique form cancer immunotherapy. It be argued PDT-inflicted tumour tissue injury provokes situ vaccination effect. end perspective paper, express our opinion challenges future directions field + Graphical
Language: Английский
Citations
1
Cells, Journal Year: 2024, Volume and Issue: 13(15), P. 1281 - 1281
Published: July 30, 2024
Cellular senescence has been increasingly recognized as a hallmark of cancer, reflecting its association with aging and inflammation, role response to deregulated proliferation oncogenic stress, induction by cancer therapies. While therapy-induced (TIS) linked resistance, recurrence, metastasis, normal tissue toxicity, TIS also the potential enhance therapy stimulate anti-tumor immunity. In this review, we examine Jekyll Hyde nature senescent cells (SnCs), focusing on how their persistence while expressing senescence-associated secretory phenotype (SASP) modulates tumor microenvironment through autocrine paracrine mechanisms. Through SASP, SnCs can mediate both resistance To fulfill unmet immunotherapy, consider may influence inflammation serve an antigen source potentiate immune response. This new perspective suggests treatment approaches based checkpoint blockade. Finally, describe strategies for mitigating detrimental effects senescence, such modulating SASP or targeting SnC persistence, which overall benefits treatment.
Language: Английский
Citations
7
Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(16), P. 4045 - 4064
Published: Jan. 1, 2024
With the increasing research and deepening understanding of glioblastoma (GBM) tumour microenvironment (TME), novel more effective therapeutic strategies have been proposed. The GBM TME involves intricate interactions between non-tumour cells, promoting progression. Key goals for treatment include improving immunosuppressive microenvironment, enhancing cytotoxicity immune cells against tumours, inhibiting growth proliferation. Consequently, remodeling using nanotechnology has emerged as a promising approach. Nanoparticle-based drug delivery enables targeted delivery, thereby specificity, facilitating combination therapies, optimizing metabolism. This review provides an overview discusses methods nanotechnology. Specifically, it explores application in ameliorating cell immunosuppression, inducing immunogenic death, stimulating, recruiting regulating metabolism, modulating crosstalk tumours other cells.
Language: Английский
Citations
5
Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Language: Английский
Citations
5
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: Sept. 18, 2024
Language: Английский
Citations
4