FOXP3 as a prognostic marker and therapeutic target in immunogenic cell death modulation for clear cell renal cell carcinoma DOI Creative Commons
Jian Chen,

Cheng Zhu,

Yan He

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 30, 2025

Abstract Background Clear cell renal carcinoma (ccRCC) remains a challenging cancer type due to its resistance standard treatments. Immunogenic death (ICD) has the potential activate anti-tumor immunity, presenting promising avenue for ccRCC therapies. Methods We analyzed data from GSE29609, TCGA-KIRC, and GSE159115 identify ICD-related prognostic genes in ccRCC. By applying consensus clustering, patients were categorized based on ICD modification patterns, an signature (ICDS) model was developed using PCA approach. Functional studies conducted with FOXP3 knockdown lines explore impact behavior. Results Eleven identified as key indicators ccRCC, high ICDS linked worse survival outcomes. High also correlated increased levels of immune-suppressive cells within tumor microenvironment. highlighted critical gene influencing ICD, where significantly reduced proliferation migration, underscoring role progression. Conclusions This study establishes pivotal factor regulation Targeting other pathways could enhance treatment efficacy providing foundation ICD-based therapeutic strategies. Evaluating patterns may guide patient-specific interventions, paving way improved management this aggressive cancer.

Language: Английский

The hallmarks of cancer immune evasion DOI
Claudia Galassi, Timothy A. Chan, Ilio Vitale

et al.

Cancer Cell, Journal Year: 2024, Volume and Issue: 42(11), P. 1825 - 1863

Published: Oct. 10, 2024

Language: Английский

Citations

78
AND-gated protease-activated nanosensors for programmable detection of anti-tumour immunity DOI
Anirudh Sivakumar, Hathaichanok Phuengkham,

Hitha Rajesh

et al.

Nature Nanotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Language: Английский

Citations

2
Dual-Enzyme-Instructed Peptide Self-Assembly to Boost Immunogenic Cell Death by Coordinating Intracellular Calcium Overload and Chemotherapy DOI
H. H. Zhang, Yuhan Hu,

Yinghao Ding

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: 19(1), P. 488 - 503

Published: Jan. 4, 2025

The concept of immunogenic cell death (ICD) induced by chemotherapy as a potential synergistic modality for cancer immunotherapy has been widely discussed. Unfortunately, most chemotherapeutic agents failed to dictate effective ICD responses due their defects in inducing potent signaling. Here, we report dual-enzyme-instructed peptide self-assembly platform CPMC (CPT-GFFpY-PLGVRK-Caps) that cooperatively utilizes camptothecin (CPT) and capsaicin (Caps) promote engage systemic adaptive immunity tumor rejection. Although CPT Caps respectively prevent progression inhibiting type-I DNA topoisomerase activating transient receptor cation channel subfamily V member 1 (TRPV1) intracellular calcium overload, neither alone effectively stimulates sufficient signaling meet immunotherapeutic needs. CPMC, sequentially allowing an active derivative VRK-Caps release extracellularly intracellularly, can synergize two distinct apoptosis pathways stimulated increase immunogenicity elicit T-cell-based immunity. Consequently, facilitates the generation improved tumor-specific cytotoxic T-cell sustained immunological memory, successfully suppressing both primary distant tumors. Moreover, render tumors susceptible PD-L1 blockade with antiprogrammed death-ligand (aPDL1) antibody inhibition. Combining drugs low ICD-stimulating capacity using strategy was demonstrated boost potentiate immunotherapy.

Language: Английский

Citations

2
Immunogenicity of cell death and cancer immunotherapy with immune checkpoint inhibitors DOI Creative Commons
Elena Catanzaro, Manuel Beltrán‐Visiedo, Lorenzo Galluzzi

et al.

Cellular and Molecular Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

While immunotherapy with immune checkpoint inhibitors (ICIs) has revolutionized the clinical management of various malignancies, a large fraction patients are refractory to ICIs employed as standalone therapeutics, necessitating development combinatorial treatment strategies. Immunogenic cell death (ICD) inducers have attracted considerable interest partners for ICIs, at least in part owing their ability initiate tumor-targeting adaptive response. However, compared either approach alone, regimens involving ICD and not always shown superior activity. Here, we discuss accumulating evidence on therapeutic interactions between oncological settings, identify key factors that may explain discrepancies preclinical findings, propose strategies address existing challenges increase efficacy these combinations cancer.

Language: Английский

Citations

11
Fe/Mo‐Based Lipid Peroxidation Nanoamplifier Combined with Adenosine Immunometabolism Regulation to Augment Anti‐Breast Cancer Immunity DOI Open Access
Qinyanqiu Xiang, Xue Yang, Zhi‐Qi Zhang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Immunogenic cell death (ICD)-mediated immunization strategies have great potential against breast cancer. However, traditional neglect the increase in immunosuppressive metabolite, adenosine (ADO), during ICD, leading to insufficient therapeutic outcomes. In this study, it is found that A2A receptor (A2AR) significantly expressed cancer and positively associated with regulatory T (Treg) cells. Herein, a strategy combining Fe/Mo-based lipid peroxidation (LPO) nanoamplifiers A2AR blockade reported maximize ICD-mediated anti-tumor immunity. This LPO nanoamplifier causes explosion by Fe (II)-mediated Fenton reaction Mo(V)-mediated Russell mechanism. Subsequently, elicits ICD magnification of tumor cells inducing multiple regulated patterns ferroptosis, apoptosis, necroptosis. Additionally, antagonist (SCH58261), an immunometabolic checkpoint blocker, relieve ADO-related immunosuppression, amplify immunological effects, elicit immune memory responses. robust immunity observed primary, distant, pulmonary metastatic, recurrent tumors. study provides novel for optimizing immunotherapy highlights benefits enhance immunotherapy.

Language: Английский

Citations

1
Prognostic models of immune-related cell death and stress unveil mechanisms driving macrophage phenotypic evolution in colorectal cancer DOI Creative Commons
Hao Liu, Chuhan Zhang,

Sanfei Peng

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 28, 2025

Tumor microenvironment (TME), particularly immune cell infiltration, programmed death (PCD) and stress, has increasingly become a focal point in colorectal cancer (CRC) treatment. Uncovering the intricate crosstalk between these factors can enhance our understanding of CRC, guide therapeutic strategies, improve patient prognosis. We constructed an immune-related stress (ICDS) prognostic model utilizing machine learning methodologies. Furthermore, we performed enrichment analyses deconvolution algorithms to elucidate complex interactions infiltration processes PCD within substantial array transcriptomic data from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus base (GEO) related CRC. Single-cell sequencing biochemical experiments were used validate interaction genes tumor cells. ICDS exhibited robust predictive performance seven independent cohorts, revealing inverse correlation scores Meanwhile, index was positively correlated with clinical stage. Model analysis indicated that subgroups low heightened activation features elevated activity pathways. further revealed macrophages central drivers characteristics underlying differences model. Pseudotime cellular gene GAL3ST4 promotes transition toward M2 pro-tumor phenotype. communication experimental validation cuproptosis cells suppress expression, thereby inhibiting M2-like macrophage polarization. In summary, uncovered mechanism by which downregulate expression via inhibit polarization, providing new targets biomarkers for CRC treatment prognosis evaluation.

Language: Английский

Citations

1
Mesoporous dual-atom nanozyme induced cuproptosis and apoptosis for boosting immunogenic cell death along with reprogramming tumor immune-suppressive microenvironment DOI
Yunhao Wang, Lei Ding, Zhan Lin

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 506, P. 160294 - 160294

Published: Jan. 1, 2025

Language: Английский

Citations

1
Enhancing antitumour immunity with photodynamic therapy DOI Creative Commons
Pål Kristian Selbo, Mladen Korbelik

Photochemical & Photobiological Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Abstract In this perspective, we present and discuss pre-clinical some clinical studies demonstrating that local photodynamic therapy (PDT) per se is a treatment modality can induce systemic anti-tumour immunity, however, the efficacy strongly enhanced when PDT combined with other modalities, e.g., vaccines or ICI therapy. has been recognized for over 30 years as inducing strong immune effects in treated tumours. More recently, become perceived distinct type of immunogenic antitumor an attractive potential use unique form cancer immunotherapy. It be argued PDT-inflicted tumour tissue injury provokes situ vaccination effect. end perspective paper, express our opinion challenges future directions field + Graphical

Language: Английский

Citations

1
Therapy-Induced Cellular Senescence: Potentiating Tumor Elimination or Driving Cancer Resistance and Recurrence? DOI Creative Commons
Yue Liu,

Isabelle Lomeli,

Stephen J. Kron

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(15), P. 1281 - 1281

Published: July 30, 2024

Cellular senescence has been increasingly recognized as a hallmark of cancer, reflecting its association with aging and inflammation, role response to deregulated proliferation oncogenic stress, induction by cancer therapies. While therapy-induced (TIS) linked resistance, recurrence, metastasis, normal tissue toxicity, TIS also the potential enhance therapy stimulate anti-tumor immunity. In this review, we examine Jekyll Hyde nature senescent cells (SnCs), focusing on how their persistence while expressing senescence-associated secretory phenotype (SASP) modulates tumor microenvironment through autocrine paracrine mechanisms. Through SASP, SnCs can mediate both resistance To fulfill unmet immunotherapy, consider may influence inflammation serve an antigen source potentiate immune response. This new perspective suggests treatment approaches based checkpoint blockade. Finally, describe strategies for mitigating detrimental effects senescence, such modulating SASP or targeting SnC persistence, which overall benefits treatment.

Language: Английский

Citations

7
Strategically engineered Au(I) complexes for orchestrated tumor eradication via chemo-phototherapy and induced immunogenic cell death DOI Creative Commons
Na Feng, Zhen Peng, Xin Zhang

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 18, 2024

Language: Английский

Citations

6