Overview of intentionally used food contact chemicals and their hazards

Environment International, Journal Year: 2020, Volume and Issue: 150, P. 106225 - 106225

Published: Nov. 30, 2020

Food contact materials (FCMs) are used to make food articles (FCAs) that come into with and beverages during, e.g., processing, storing, packaging, or consumption. FCMs/FCAs can cause chemical contamination of when migration their constituents (known as chemicals, FCCs) occurs. Some FCCs known be hazardous. However, the total extent exposure FCCs, well health environmental effects, remain unknown, because information on structures, use patterns, potential, effects is often absent scattered across multiple sources. Therefore, we initiated a research project systematically collect, analyze, publicly share FCCs. As first step, compiled database intentionally added chemicals (FCCdb), presented here. The FCCdb lists 12′285 substances could possibly worldwide FCMs/FCAs, identified based 67 FCC from available sources, such regulatory industry inventories. We further explored chemicals' hazards using several authoritative sources hazard information, including (i) classifications for under globally harmonized system classification labeling (GHS), (ii) identification concern due endocrine disruption persistence related hazards, (iii) inclusion selected EU- US-relevant hazardous chemicals. This analysis prioritized 608 assessment substitution in FCMs/FCAs. Evaluation non-authoritative, predictive data (e.g., by silico modeling literature analysis) highlighted an additional 1411 thus present similar levels concern, but have not been officially classified so far. Lastly, over quarter all no found consulted, revealing significant gap need.

Language: Английский

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Association Between Bisphenol A Exposure and Risk of All-Cause and Cause-Specific Mortality in US Adults

JAMA Network Open, Journal Year: 2020, Volume and Issue: 3(8), P. e2011620 - e2011620

Published: Aug. 17, 2020

Importance

Bisphenol A (BPA) is a major public health concern because of its high-volume industrial production, ubiquitous exposure to humans, and potential toxic effects on multiple organs systems in humans. However, prospective studies regarding the association BPA with long-term outcomes are sparse.

Objective

To examine all-cause mortality cause-specific among adults United States.

Design, Setting, Participants

This nationally representative cohort study included 3883 aged 20 years or older who participated US National Health Nutrition Examination Survey 2003-2008 provided urine samples for level measurements. Participants were linked data from survey date through December 31, 2015. Data analyses conducted July 2019.

Exposures

Urinary levels quantified using online solid-phase extraction coupled high-performance liquid chromatography–isotope dilution tandem mass spectrometry.

Main Outcomes Measures

Mortality all causes, cardiovascular disease, cancer.

Results

(weighted mean [SE] age, 43.6 [0.3] years; 2032 women [weighted, 51.4%]). During 36 514 person-years follow-up (median, 9.6 maximum, 13.1 years), 344 deaths occurred, including 71 disease 75 higher urinary at risk death. After adjustment sex, race/ethnicity, socioeconomic status, dietary lifestyle factors, body index, creatinine levels, hazard ratio comparing highest vs lowest tertile was 1.49 (95% CI, 1.01-2.19) mortality, 1.46 0.67-3.15) 0.98 0.40-2.39) cancer mortality.

Conclusions Relevance

In this adults, significantly associated an increased Further needed replicate these findings other populations determine underlying mechanisms.

Language: Английский

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Bisphenol A and Phthalates in Diet: An Emerging Link with Pregnancy Complications

Nutrients, Journal Year: 2020, Volume and Issue: 12(2), P. 525 - 525

Published: Feb. 19, 2020

Endocrine-disrupting chemicals (EDCs) are exogenous substances that able to interfere with hormone action, likely contributing the development of several endocrine and metabolic diseases. Among them, Bisphenol A (BPA) phthalates contaminate food water have been largely studied as obesogenic agents. They might contribute weight gain, insulin resistance pancreatic β-cell dysfunction in pregnancy, potentially playing a role pregnancy complications, such gestational diabetes mellitus (GDM), adverse outcomes. Pregnancy childhood sensitive windows susceptibility, and, although not univocal results, preclinical clinical studies suggested exposure BPA at these stages life an impact on diseases even many years later. The molecular mechanisms underlying this association unknown, but adipocyte suspected be involved. Remarkably, transgenerational damage has observed, which explained by epigenetic changes. Further research is needed address knowledge gaps provide preventive measure limit health risks connected EDCs.

Language: Английский

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Endocrine-Disrupting Chemicals and Child Health

The Annual Review of Pharmacology and Toxicology, Journal Year: 2021, Volume and Issue: 62(1), P. 573 - 594

Published: Sept. 23, 2021

While definitions vary, endocrine-disrupting chemicals (EDCs) have two fundamental features: their disruption of hormone function and contribution to disease disability. The unique vulnerability children low-level EDC exposures has eroded the notion that only dose makes thing a poison, requiring paradigm shift in scientific policy practice. In this review, we discuss as early fetal life provide an overview epidemiological studies on programming effects EDCs neuronal, metabolic, immune pathways well endocrine, reproductive, renal systems. Building accumulating evidence, dispel address existing myths about health with examples from child research. Finally, list effective actions reduce exposure subsequent harm are applicable individuals, communities, policy-makers.

Language: Английский

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Tackling the toxics in plastics packaging

PLoS Biology, Journal Year: 2021, Volume and Issue: 19(3), P. e3000961 - e3000961

Published: March 30, 2021

The widespread use of plastic packaging for storing, transporting, and conveniently preparing or serving foodstuffs is significantly contributing to the global pollution crisis. This has led many efforts directed toward amending packaging’s end life, such as recycling, alternative material approaches, like increasingly using paper food packaging. But these approaches often neglect critical issue chemical migration: When contacting foodstuffs, chemicals that are present in transfer into thus unwittingly become part human diet. Hazardous chemicals, endocrine disrupters, carcinogens, substances bioaccumulate, collectively referred “chemicals concern.” They can from food, together with other unknown toxicologically uncharacterized chemicals. scientifically undisputed makes a known, avoidable, source exposure synthetic, hazardous, untested Here, I discuss this highlight aspects need improvement, namely way assessed toxicity. Further, provide an outlook on how contamination could be addressed future. Robust innovations must attempt systemic change tackle migration integrates all existing knowledge.

Language: Английский

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Drivers of owning more BPA

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 417, P. 126076 - 126076

Published: May 11, 2021

Language: Английский

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BPA, BPAF and TMBPF Alter Adipogenesis and Fat Accumulation in Human Mesenchymal Stem Cells, with Implications for Obesity

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(10), P. 5363 - 5363

Published: May 19, 2021

Bisphenol A (BPA) is an endocrine-disrupting chemical used in the production of plastics, and linked to developmental, reproductive, metabolic disorders including obesity. Manufacturers have begun using ‘BPA-free’ alternatives instead BPA many consumer products. However, these had much less testing oversight, yet they are already being mass-produced across industries from plastics food-contact coatings. Here, we human female adipose-derived stem cells (hASCs), a type adult mesenchymal cell, compare effects on adipogenesis or fat cell development vitro. We focused two commonly replacements, bisphenol AF (BPAF) tetramethyl F (TMBPF; monomer new valPure V70 coating). Human ASCs were differentiated into adipocytes chemically defined media presence control differentiation with without 17β-estradiol (E2; 10 μM), increasing doses (0, 0.1 1 BPAF 0.1, nM), TMBPF 0.01 μM). After differentiation, stained imaged visualize quantify accumulation lipid vacuoles number developing cells. Treated also examined for viability apoptosis (programmed death) respective cellular assays. Similar E2, at μM nM, significantly increased by 20% compared (based total vacuole ratios), whereas higher levels decreased (p < 0.005). All tested reduced 30–40%, likely least partially through toxic cells, as viable numbers throughout differentiation. These findings indicate that low, environmentally-relevant BPA, BPAF, significant accumulation, having non-estrogenic, anti-adipogenic effects. other recent results may provide potential mechanism between exposure bisphenols obesity, underscore impact chemicals vivo.

Language: Английский

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WS2-cocatalyzed peroxymonosulfate activation via an enhanced Fe(III)/Fe(II) cycle toward efficient organic pollutant degradation

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 442, P. 135961 - 135961

Published: March 23, 2022

Language: Английский

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The Effects of Bisphenol A on Human Male Infertility: A Review of Current Epidemiological Studies

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12417 - 12417

Published: Aug. 4, 2023

Endocrine disruptor chemicals (EDCs) can have a harmful effect on the human body’s endocrine system and thus adversely affect development, reproduction, neurological, cardiovascular, immune systems metabolism in humans wildlife. According to World Health Organization, EDCs are mostly man-made found ubiquitously our daily lives, notably pesticides, metals, additives or contaminants food personal care products. Human exposure occurs through ingestion, inhalation, dermal contact. Bisphenol A (BPA) is proven EDC capable of mimicking blocking receptors altering hormone concentrations metabolism. Although consumed low doses, it stimulate cellular responses functions. In humans, BPA has been correlated with onset development several diseases. This literature review aimed verify effects male infertility using most recently published literature. Thus, this allowed us conclude that compound seems fertility, causing changes hormonal semen characteristics. However, these conclusions lack more robust reproducible scientific studies. Even so, since prevalence increasing, preventive measures must be taken ensure fertility.

Language: Английский

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Endocrine-active and endocrine-disrupting compounds in food – occurrence, formation and relevance

NFS Journal, Journal Year: 2023, Volume and Issue: 31, P. 57 - 92

Published: March 20, 2023

Over the last decades, global concerns regarding possible adverse health effects of chemical pollutants on hormonal systems living organisms in wildlife and humans are constantly growing. Endocrine-active endocrine-disrupting chemicals (EDC) belong to a heterogeneous class exogenous chemicals, including various persistent anthropogenic contaminants, pesticides, distinct substances used consumer products, also natural compounds. Exposure through food chain is considered essential for most EDC, while they may enter as residues from animal- or plant-based production (e.g. pesticides pharmaceutical residues), be released contact materials, present due contamination mycoestrogens), via polluted environment plant ingredients phytoestrogens). The complexity subject to: a) ubiquitous occurrence hardly avoidance many with supposed endocrine properties, b) scientific disagreement among experts huge number partly controversial study outcomes c) increasing pressure public, necessitating higher level transparency clear-cut orientation respect reduction strategies. In this light, current review intends provide an overview historical regulatory developments topic discusses important difference between endocrine-active disruptive presents some key characteristics acting better understanding their relevance long-term effects, windows sensitivity, low-dose “cocktail” effects. addition, comprehensive different exposure paths given, both focus naturally occurring contaminations external sources.

Language: Английский

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