Cureus,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Jan. 25, 2023
Polycystic
ovarian
syndrome
(PCOS)
is
a
metabolic,
reproductive,
and
psychological
complex
series
of
disorders
that
impacts
woman
throughout
her
lifespan.
PCOS
disorder
hormonal
imbalance
occurring
in
women
reproductive
age.
This
characterized
by
high
levels
male
androgens
like
testosterone.
can
lead
to
symptoms
irregular
periods,
amenorrhea
(absence
menstruation),
anovulation
ovulation),
hirsutism,
acne,
obesity.
also
causes
metabolic
impairment.
Multiple
peripherally
arranged
immature
follicles
about
2-5mm
diameter
are
present
the
ovary.
These
do
not
mature
due
imbalances
leading
an
menstrual
cycle.
fatal
or
life-threatening
as
its
main
complication
infertility.
be
root
cause
serious
medical
conditions
obesity,
hypertension,
type-2
diabetes
mellitus
insulin
resistance,
endometrial
cancers,
cancer,
etc.
Stress
may
hormone
pituitary
fluctuate.
Since
cycle
hormone-based,
there
apparent
irregularities.
Genes,
Journal Year:
2022,
Volume and Issue:
13(2), P. 302 - 302
Published: Feb. 5, 2022
Polycystic
ovary
syndrome
is
a
multifactorial
condition
associated
with
reproductive
and
endocrine
organs
might
cause
infertility
metabolic
abnormalities
in
childbearing
age.
PCOS
seems
to
be
disorder
resulting
from
the
combination
of
several
genetic
environmental
factors.
Little
research
has
been
conducted
date
on
impact
polymorphisms
infertility.
We
aim
review
appearance
females
diverse
ethnicities
their
effect
population
polycystic
syndrome.
There
have
numerous
reports
importance
steroidogenesis
pathway
variants
pathogenesis.
The
most
important
genes
that
play
role
aetiology
are
CYP11A1,
CYP17A1,
CYP19A1.
evaluated
occurrence
various
CYP19A1
efficacy
increasing
risk
Our
findings
revealed
Although
conflicting
results
regarding
influence
reported
small
number
papers,
authors
feel
this
may
attributable
sample
size
ethnic
composition
examined
populations.
In
conclusion,
our
study
strongly
suggests
significantly
enhance
probability
developing
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(6), P. 1567 - 1567
Published: May 28, 2023
Infertility
has
been
recognized
as
a
civilizational
disease.
One
of
the
most
common
causes
infertility
is
polycystic
ovary
syndrome
(PCOS).
Closely
interrelated
immunometabolic
mechanisms
underlie
development
this
complex
and
lead
to
infertility.
The
direct
cause
in
PCOS
ovulation
implantation
disorders
caused
by
low-grade
inflammation
ovarian
tissue
endometrium
which,
turn,
result
from
immune
metabolic
system
disorders.
systemic
response,
particular
inflammatory
conjunction
with
disorders,
insulin
resistance
(IR),
hyperadrenalism,
insufficient
secretion
progesterone,
oxidative
stress
not
only
cardiovascular
diseases,
cancer,
autoimmunity,
lipid
metabolism
but
also
Depending
on
genetic
environmental
conditions
well
certain
cultural
factors,
some
diseases
may
occur
immediately,
while
others
become
apparent
years
after
an
diagnosis.
Each
them
alone
can
be
significant
factor
contributing
Further
research
will
allow
clinical
management
protocols
established
for
patients
experiencing
so
that
targeted
therapy
approach
applied
underlying
driving
“vicious
circle”
alongside
symptomatic
treatment
stimulation.
Hence,
fertility
should
conducted
interdisciplinary
teams
specialists
in-depth
understanding
molecular
relationships
implications
between
immunological
factors
trigger
reproductive
necessary
restore
physiology
homeostasis
body
and,
thus,
fertility,
among
patients.
Abstract
Recent
advances
in
understanding
the
modulatory
functions
of
gut
and
microbiota
on
human
diseases
facilitated
our
focused
attention
contribution
to
pathophysiological
alterations
many
extraintestinal
organs,
including
liver,
heart,
brain,
lungs,
kidneys,
bone,
skin,
reproductive,
endocrine
systems.
In
this
review,
we
applied
“gut–X
axis”
concept
describe
linkages
between
other
organs
discussed
latest
findings
related
axis,”
underlying
mechanisms
potential
clinical
intervention
strategies.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(6), P. 3350 - 3350
Published: March 20, 2022
Similar
to
environmental
factors,
EDCs
(endocrine-disrupting
chemicals)
can
influence
gene
expression
without
modifying
the
DNA
sequence.
It
is
commonly
accepted
that
transgenerational
inheritance
of
parentally
acquired
traits
conveyed
by
epigenetic
alterations
also
known
as
"epimutations".
methylation,
acetylation,
histone
modification,
RNA-mediated
effects
and
extracellular
vesicle
are
mechanisms
have
been
described
so
far
be
responsible
for
these
epimutations.
They
may
lead
diverse
phenotypes
in
progeny
when
they
occur
germ
cells
an
affected
individual.
While
EDC-induced
health
dramatically
increased
over
past
decade,
limited
on
sperm
epigenetics
described.
However,
there
has
a
gain
interest
this
issue
recent
years.
The
gametes
(sperm
oocyte)
represent
targets
thus
route
environmentally
induced
changes
several
generations.
This
review
aims
at
providing
overview
might
implicated
inheritance.
Cell Reports Medicine,
Journal Year:
2023,
Volume and Issue:
4(5), P. 101035 - 101035
Published: May 1, 2023
The
transgenerational
maternal
effects
of
polycystic
ovary
syndrome
(PCOS)
in
female
progeny
are
being
revealed.
As
there
is
evidence
that
a
male
equivalent
PCOS
may
exists,
we
ask
whether
sons
born
to
mothers
with
(PCOS-sons)
transmit
reproductive
and
metabolic
phenotypes
their
progeny.
Here,
register-based
cohort
clinical
case-control
study,
find
PCOS-sons
more
often
obese
dyslipidemic.
Our
prenatal
androgenized
PCOS-like
mouse
model
or
without
diet-induced
obesity
confirmed
dysfunctions
first-generation
(F1)
offspring
passed
down
F3.
Sequencing
F1-F3
sperm
reveals
distinct
differentially
expressed
(DE)
small
non-coding
RNAs
(sncRNAs)
across
generations
each
lineage.
Notably,
common
targets
between
DEsncRNAs
serum
indicate
similar
hyperandrogenism,
strengthening
the
translational
relevance
highlighting
previously
underappreciated
risk
transmission
dysfunction
via
germline.
