Journal of Endocrinological Investigation, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 16, 2024
Language: Английский
Nature Reviews Disease Primers, Journal Year: 2024, Volume and Issue: 10(1)
Published: April 18, 2024
Language: Английский
Citations
92
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 949, P. 174972 - 174972
Published: July 23, 2024
Language: Английский
Citations
13
Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(2)
Published: Feb. 17, 2025
Polycystic ovary syndrome (PCOS) is a prevalent gynecological endocrine and metabolic disorder in women, with an incidence rate of 10-13%. The etiology PCOS multifaceted, involving genetic predisposition, environmental influences, lifestyle factors, dysregulation. Iron, critical mineral, not only plays role regulating female physiological functions the progression but also requires careful management to avoid deficiency. However, excess iron can trigger ferroptosis, form nonapoptotic cell death characterized by accumulation lipid peroxides. While numerous studies have explored ferroptosis patients animal models, precise mechanisms therapeutic implications remain inadequately understood. This review seeks elucidate pathophysiology contributory factors ferroptosis. Additionally, we examine diverse manifestations evaluate its role. Furthermore, introduce ferroptosis-related traditional Chinese medicines that may enhance understanding pathogenesis aid development targeted therapies for PCOS.
Language: Английский
Citations
1
Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11
Published: Jan. 16, 2024
Recently, the use of assisted reproductive technology (ART) has rapidly increased. As a result, an increasing number people are concerned about safety offspring produced through ART. Moreover, emerging evidence suggests increased risk cardiovascular disease (CVD) in conceived using In this review, we discuss epigenetic mechanisms involved altered DNA methylation, histone modification, and microRNA expression, as well imprinting disorders. We also summarize studies on changes other factors for disease, such adverse intrauterine environments, perinatal complications, metabolism following (ART). Finally, emphasize underlying CVD ART, which could contribute to early diagnosis prevention ART population.
Language: Английский
Citations
5
Advanced Science, Journal Year: 2024, Volume and Issue: unknown
Published: July 29, 2024
Abstract Women with polycystic ovary syndrome (PCOS) exhibit sustained elevation in circulating androgens during pregnancy, an independent risk factor linked to pregnancy complications and adverse outcomes offspring. Yet, further studies are required understand the effects of elevated on cell type‐specific placental dysfunction fetal development. Therefore, a PCOS‐like mouse model induced by continuous androgen exposure is examined. The PCOS‐mice exhibited impaired embryonic development, resulting mid‐gestation lethality. Co‐treatment receptor blocker, flutamide, prevents these phenotypes including germ specification . Comprehensive profiling placenta whole‐genome bisulfite RNA sequencing shows reduced proportion trophoblast precursors, possibly due downregulation Cdx2 expression. Reduced expression Gcm1 , Synb Prl3b1 associated syncytiotrophoblasts sinusoidal giant cells, impairs labyrinth formation. Importantly, human organoids exposed analogous changes, showing differentiation as key feature PCOS‐related complications. These findings provide new insights into potential cellular targets for future treatments.
Language: Английский
Citations
5
Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14
Published: Oct. 20, 2023
Polycystic ovary syndrome (PCOS) is a multifaceted disorder that impacts metabolism, reproduction, as well endocrine function, characterized by excessive levels of androgen and insulin resistance. The gut microbiota has been implicated in the pathogenesis PCOS. However, precise mechanisms through which influences PCOS still require further elucidation. mouse model was established administration letrozole to both conventional antibiotics-treated mice. evaluation glucose sex hormone levels, ovarian morphology conducted. Furthermore, fecal samples from each group mice were subjected 16S rRNA gene sequencing, functional prediction proceeded using PICRUSt2 explore potential mechanisms. By letrozole-induced model, we manifested antibiotic intervention significantly reduced serum total testosterone level ameliorated intolerance. Antibiotic treatment number amplicon sequence variants (ASVs), Shannon Simpson index. Meanwhile, induced significant increase index instead ASVs. Through random forest analysis, results revealed alterations three distinct groups microbiota, namely Clostridia_vadinBB60_group, Enterorhabdus, Muribaculaceae after treatment. Further correlation analysis positive association between these area under curve (AUC) blood IPGTT. antibiotics led decrease absolute abundance 5 ASVs belonging unclassified Muribaculaceae, exhibited with serum, Moreover, 25 pathways microbiome discrepant letrozole-treated without antibiotics. These suggest disturbance may take participate progression manipulating composition be therapeutic approach for managing
Language: Английский
Citations
11
Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 45(11), P. e1681242024 - e1681242024
Published: March 12, 2025
Early age at menarche (early AAM) and polycystic ovary syndrome (PCOS) are reproductive metabolic disorders with overlapping pathophysiological genetic features. Epidemiological studies suggest a link between these two conditions, both of which characterized by dysregulation the neuroendocrine pathways that control pulsatile gonadotropin-releasing hormone secretion, thus affecting gonadotropin release, particularly luteinizing secretion. A common pathophysiology involving positive energy balance abnormal status is evident in disorders. Genetic epigenetic factors influence onset puberty outcomes. Genome-wide association have identified variants associated AAM PCOS, genes related to axis (e.g., FSHB) obesity FTO). In addition, high-throughput sequencing has revealed rare loss-of-function DLK1 gene women central precocious (CPP), early menarche, who experienced adverse outcomes adulthood. This review explores shared mechanisms CPP/early examines potential may offers insights into future research treatment strategies. Understanding connections provide new targets for therapeutic interventions improve individuals
Language: Английский
Citations
0
Cell Metabolism, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Polycystic ovary syndrome (PCOS), the most common endocrinopathy in women, causes significant reproductive and metabolic comorbidities, with no current cure. Gestational androgen anti-Müllerian hormone (AMH) excess are linked to PCOS, prenatal aberrant exposure these hormones induces PCOS-like traits animal models. However, whether AMH effects on PCOS programming could extend early postnatal life remains unknown. Clinical observations showed higher levels during minipuberty infants of mothers but this contributes development is uncertain. Here, we show that high mice defects both sexes. A neutralizing antibody targeting receptor 2 (AMHR2) prevented when administered alleviated symptoms given adulthood. These findings highlight causal role elevated suggest AMHR2-targeting therapy as a potential preventive or curative approach.
Language: Английский
Citations
0
Annales d Endocrinologie, Journal Year: 2025, Volume and Issue: 86(3), P. 101774 - 101774
Published: May 6, 2025
Language: Английский
Citations
0
Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Citations
3