White adipocyte dysfunction and obesity-associated pathologies in humans

Nature Reviews Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 25(4), P. 270 - 289

Published: Dec. 12, 2023

Language: Английский

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Fat infiltration in skeletal muscle: Influential triggers and regulatory mechanism

iScience, Journal Year: 2024, Volume and Issue: 27(3), P. 109221 - 109221

Published: Feb. 15, 2024

Fat infiltration in skeletal muscle (also known as myosteatosis) is now recognized a distinct disease from sarcopenia and directly related to declining capacity. Hence, understanding the origins regulatory mechanisms of fat vital for maintaining development improving human health. In this article, we summarized triggering factors such aging, metabolic diseases syndromes, nonmetabolic diseases, injury that all induce muscle. We discussed recent advances on cellular found several cell types including myogenic cells non-myogenic contribute myosteatosis. Furthermore, reviewed molecular mechanism, detection methods, intervention strategies Based current findings, our review will provide new insight into regulating function lipid metabolism treating muscle-related diseases.

Language: Английский

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The impact of bed rest on human skeletal muscle metabolism

Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(1), P. 101372 - 101372

Published: Jan. 1, 2024

Insulin sensitivity and metabolic flexibility decrease in response to bed rest, but the temporal causal adaptations human skeletal muscle metabolism are not fully defined. Here, we use an integrative approach assess during rest provide a multi-system analysis of how circulatory system adapt short- long-term (German Clinical Trials: DRKS00015677). We uncover that intracellular glycogen accumulation after short-term accompanies rapid reduction systemic insulin less GLUT4 localization at cell membrane, preventing further deposition rest. evidence link between triglycerides, lipotoxic ceramides, sphingomyelins altered mitochondrial structure function An nutrient overload therefore represents crucial determinant for insensitivity alterations prolonged

Language: Английский

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Skeletal muscle adiposity, coronary microvascular dysfunction, and adverse cardiovascular outcomes

European Heart Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Abstract Background and Aims Skeletal muscle (SM) fat infiltration, or intermuscular adipose tissue (IMAT), reflects quality is associated with inflammation, a key determinant in cardiometabolic disease. Coronary flow reserve (CFR), marker of coronary microvascular dysfunction (CMD), independently body mass index (BMI), inflammation risk heart failure, myocardial infarction, death. The relationship between SM quality, CMD, cardiovascular outcomes not known. Methods Consecutive patients (n = 669) undergoing evaluation for artery disease cardiac stress positron emission tomography demonstrating normal perfusion preserved left ventricular ejection fraction were followed over median 6 years major adverse events (MACEs), including death hospitalization infarction failure. was calculated as stress/rest blood flow. Subcutaneous (SAT), SM, IMAT areas (cm2) obtained from simultaneous attenuation correction computed using semi-automated segmentation at the 12th thoracic vertebra level. Results Median age 63 years, 70% female, 46% nonwhite. Nearly half obese (46%, BMI 30–61 kg/m2), correlated highly SAT (r .84 r .71, respectively, P < .001) moderately .52, .001). Decreased increased IMAT, but SAT, remained decreased CFR (adjusted .03 .04, respectively). In adjusted analyses, both lower higher MACE [hazard ratio 1.78 (95% confidence interval 1.23–2.58) per −1 U 1.53 (1.30–1.80) +10 cm2 .002 .0001, respectively], while protective .89 (.81–.97) .94 (.91–.98) .01 .003, respectively]. Every 1% increase fatty [IMAT/(SM + IMAT)] conferred an independent 2% odds CMD [CFR <2, 1.02 (1.01–1.04), .04] 7% 1.07 (1.04–1.09), .001]. There significant interaction BMI, such that demonstrated highest .02). Conclusions Increased conventional factors. presence infiltration identified novel at-risk phenotype.

Language: Английский

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Skeletal muscle adiposity in patients with impaired coronary flow reserve: risk marker, treatment target, or bystander?

European Heart Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Graphical AbstractIncreased risk of adverse cardiovascular events—conventional and novel approaches to stratification treatment.BMI, body mass index; CACS, coronary artery calcium score; CFR, flow reserve; CMR, magnetic resonance; CT, computed tomography; EAT, epicardial adipose tissue; FAI, fat attenuation GIP, glucose-dependent insulinotropic polypeptide; GLP-1, glucagon-like peptide-1; IMAT, intramuscular MACE, major events.Open in new tabDownload slide

Language: Английский

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Poor muscle quality: A hidden and detrimental health condition in obesity

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Language: Английский

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Lycium barbarum polysaccharide mitigates high-fat-diet-induced skeletal muscle atrophy by promoting AMPK/PINK1/Parkin-mediated mitophagy

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 301, P. 140488 - 140488

Published: Jan. 29, 2025

Language: Английский

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Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men

Cell Reports Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 101968 - 101968

Published: Feb. 1, 2025

Highlights•Physical activity helps protect against age-related decline in physical performance•Physical boosts mitochondrial energetics while aging per se has no impact•Mitochondrial ROS production is unaffected by both active and inactive men•Mitochondrial calcium handling declines with age linked to muscle performanceSummaryAging-related atrophy weakness contribute loss of mobility, falls, disability. Mitochondrial dysfunction widely considered a key contributing mechanism aging. However, mounting evidence positions as confounding factor, making unclear whether mitochondria accumulate bona fide defects To disentangle from activity-related adaptations, we functionally profiled skeletal 51 88 men aged 20–93. Physical status confers partial protection performance. respiration remains unaltered participants, indicating that does not alter respiratory capacity. reactive oxygen species (ROS) higher participants. In contrast, retention capacity decreases regardless correlates mass, performance, the stress-responsive metabokine/mitokine growth differentiation factor 15 (GDF15). Targeting may hold promise for treating aging-related impairments.Graphical abstract

Language: Английский

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Myosteatosis: Diagnosis, pathophysiology and consequences in metabolic dysfunction-associated steatotic liver disease

JHEP Reports, Journal Year: 2023, Volume and Issue: 6(2), P. 100963 - 100963

Published: Nov. 14, 2023

Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with an increased risk of multisystemic complications, including muscle changes such as sarcopenia and myosteatosis that can reciprocally affect function. We conducted a systematic review to highlight innovative assessment tools, pathophysiological mechanisms metabolic consequences related in MASLD, based on original articles screened from PUBMED, EMBASE COCHRANE databases. Forty-six manuscripts (14 pre-clinical 32 clinical studies) were included. Microscopy (8/14) tissue lipid extraction are the two main techniques used measure content studies. In studies, imaging most tool included CT (14/32), MRI (12/32) ultrasound (4/32). Assessed muscles varied across studies but mainly paravertebral (4/14 pre-clinical; 13/32 lower limb (10/14 preclinical; studies). Myosteatosis already highly prevalent non-cirrhotic stages MASLD correlates activity when using density assessed by CT. Numerous found included: high-fat high-fructose diet, dysregulation fatty acid transport ketogenesis, endocrine disorders impaired microRNA122 pathway signalling. this we also uncover several potential insulin resistance, progression steatosis steatohepatitis loss strength. conclusion, data available. Screening for could be relevant context considering its correlation well consequences.

Language: Английский

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Fibro-adipogenic progenitors in physiological adipogenesis and intermuscular adipose tissue remodeling

Molecular Aspects of Medicine, Journal Year: 2024, Volume and Issue: 97, P. 101277 - 101277

Published: May 24, 2024

Excessive accumulation of intermuscular adipose tissue (IMAT) is a common pathological feature in various metabolic and health conditions can cause muscle atrophy, reduced function, inflammation, insulin resistance, cardiovascular issues, unhealthy aging. Although IMAT results from fat muscle, the mechanisms underlying its onset, development, cellular components, functions remain unclear. levels are influenced by several factors, such as changes environment, type origin, extent duration trauma, persistent activation fibro-adipogenic progenitors (FAPs). FAPs diverse transcriptionally heterogeneous population stromal cells essential for maintenance, neuromuscular stability, regeneration. However, cases chronic inflammation conditions, expand differentiate into adipocytes, resulting development abnormal ectopic IMAT. This review discusses role adipogenesis how they remodel It highlights evidence supporting FAP-derived adipocytes constituents IMAT, emphasizing their significance maintenance well involvement disorders, pathologies diseases. We also investigated intricate molecular pathways cell interactions governing FAP behavior, adipogenesis, diseases deconditioning. Finally, we hypothesize that impaired flexibility dysfunctional muscles impacts FAPs, leading to A deeper understanding biology regulating behavior fate new therapeutic strategies debilitating conditions.

Language: Английский

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