Lipid droplets and cellular lipid flux

Nature Cell Biology, Journal Year: 2024, Volume and Issue: 26(3), P. 331 - 345

Published: March 1, 2024

Language: Английский

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Fat infiltration in skeletal muscle: Influential triggers and regulatory mechanism

iScience, Journal Year: 2024, Volume and Issue: 27(3), P. 109221 - 109221

Published: Feb. 15, 2024

Fat infiltration in skeletal muscle (also known as myosteatosis) is now recognized a distinct disease from sarcopenia and directly related to declining capacity. Hence, understanding the origins regulatory mechanisms of fat vital for maintaining development improving human health. In this article, we summarized triggering factors such aging, metabolic diseases syndromes, nonmetabolic diseases, injury that all induce muscle. We discussed recent advances on cellular found several cell types including myogenic cells non-myogenic contribute myosteatosis. Furthermore, reviewed molecular mechanism, detection methods, intervention strategies Based current findings, our review will provide new insight into regulating function lipid metabolism treating muscle-related diseases.

Language: Английский

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Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(6), P. 1351 - 1370.e8

Published: April 23, 2024

Language: Английский

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Recent advances in organelle-targeted organic photosensitizers for efficient photodynamic therapy

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 506, P. 215710 - 215710

Published: Feb. 20, 2024

Language: Английский

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Fluorescent probes - illuminate the interplay network between lipid droplets and other organelles

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 510, P. 215792 - 215792

Published: March 28, 2024

Language: Английский

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Versatile organic fluorescent probes for visualizing the dynamics of lipid droplets

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216181 - 216181

Published: Sept. 5, 2024

Language: Английский

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Lipid droplets provide metabolic flexibility for cancer progression

FEBS Letters, Journal Year: 2024, Volume and Issue: 598(10), P. 1301 - 1327

Published: Feb. 7, 2024

A hallmark of cancer cells is their remarkable ability to efficiently adapt favorable and hostile environments. Due a unique metabolic flexibility, tumor can grow even in the absence extracellular nutrients or stressful scenarios. To achieve this, need large amounts lipids build membranes, synthesize lipid‐derived molecules, generate energy other nutrients. Tumor potentiate strategies obtain from cells, pathways new lipids, mechanisms for efficient storage, mobilization, utilization these lipids. Lipid droplets (LDs) are organelles that collect supply eukaryotes it increasingly recognized accumulation LDs cells. Furthermore, an active role LD proteins processes underlying tumorigenesis has been proposed. Here, by focusing on three major classes LD‐resident (perilipins, lipases, acyl‐CoA synthetases), we provide overview contribution progression discuss during proliferation, invasion, metastasis, apoptosis, stemness

Language: Английский

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Lipidome disruption in Alzheimer’s disease brain: detection, pathological mechanisms, and therapeutic implications

Molecular Neurodegeneration, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 27, 2025

Alzheimer's disease (AD) is among the most devastating neurodegenerative disorders with limited treatment options. Emerging evidence points to involvement of lipid dysregulation in development AD. Nevertheless, precise lipidomic landscape and mechanistic roles lipids pathology remain poorly understood. This review aims highlight significance lipidomics lipid-targeting approaches diagnosis We summarized connection between human brain AD at both genetic species levels. briefly introduced technologies discussed potential challenges areas future advancements field for research. To elucidate central role converging multiple pathological aspects AD, we reviewed current knowledge on interplay major features, including amyloid beta, tau, neuroinflammation. Finally, assessed progresses obstacles lipid-based therapeutics proposed strategies leveraging

Language: Английский

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Oxidative Stress and Reprogramming of Lipid Metabolism in Cancers

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 201 - 201

Published: Feb. 10, 2025

Oxidative stress is a common event involved in cancer pathophysiology, frequently accompanied by unique lipid metabolic reprogramming phenomena. caused mainly an imbalance between the production of reactive oxygen species (ROS) and antioxidant system cells. Emerging evidence has reported that oxidative regulates expression activity metabolism-related enzymes, leading to alteration cellular metabolism; this involves significant increase fatty acid synthesis shift way which lipids are taken up utilized. The dysregulation metabolism provides abundant intermediates synthesize biological macromolecules for rapid proliferation cells; moreover, it contributes maintenance intracellular redox homeostasis producing variety reducing agents. Moreover, derivatives metabolites play critical roles signal transduction within cells tumor microenvironment evades immune destruction facilitates invasion metastasis. These findings suggest close relationship during malignant progression cancers. This review focuses on crosstalk reprogramming, in-depth insight into modulation ROS cancers discusses potential strategies targeting therapy.

Language: Английский

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Protection Strategies Against Palmitic Acid-Induced Lipotoxicity in Metabolic Syndrome and Related Diseases

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 788 - 788

Published: Jan. 18, 2025

Diets rich in carbohydrate and saturated fat contents, when combined with a sedentary lifestyle, contribute to the development of obesity metabolic syndrome (MetS), which subsequently increase palmitic acid (PA) levels. At high concentrations, PA induces lipotoxicity through several mechanisms involving endoplasmic reticulum (ER) stress, mitochondrial dysfunction, inflammation cell death. Nevertheless, there are endogenous strategies mitigate PA-induced its unsaturation elongation channeling storage lipid droplets (LDs), plays crucial role sequestering oxidized lipids, thereby reducing oxidative damage membranes. While extended exposure promotes reactive oxygen species (ROS) generation leading damage, acute ß-cells increases glucose-stimulated insulin secretion (GSIS), activation free fatty receptors (FFARs). Subsequently, FFARs by exogenous agonists has been suggested as potential therapeutic strategy prevent ß cells. Moreover, some acids, including oleic acid, can counteract negative impact on cellular health, suggesting complex interaction between different dietary fats outcomes. Therefore, challenge is peroxidation unsaturated acids utilization natural antioxidants. This complexity indicates necessity for further research into function diverse pathological conditions find main target against lipotoxicity. The aim this review is, therefore, examine recent data regarding mechanism underlying order identify that promote protection lipotoxicity, dysfunction apoptosis MetS obesity.

Language: Английский

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