Crosstalk Between Autophagy and Oxidative Stress in Hematological Malignancies: Mechanisms, Implications, and Therapeutic Potential DOI Creative Commons
Antonio José Cabrera-Serrano, José Manuel Sánchez‐Maldonado, Carmen González‐Olmedo

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 264 - 264

Published: Feb. 25, 2025

Autophagy is a fundamental cellular process that maintains homeostasis by degrading damaged components and regulating stress responses. It plays crucial role in cancer biology, including tumor progression, metastasis, therapeutic resistance. Oxidative stress, similarly, key to maintaining balance oxidants antioxidants, with its disruption leading molecular damage. The interplay between autophagy oxidative particularly significant, as reactive oxygen species (ROS) act both inducers by-products of autophagy. While can function suppressor early stages, it often shifts pro-tumorigenic advanced disease, aiding cell survival under adverse conditions such hypoxia nutrient deprivation. This dual mediated several signaling pathways, PI3K/AKT/mTOR, AMPK, HIF-1α, which coordinate the autophagic activity ROS production. In this review, we explore mechanisms interact across different hematological malignancies. We discuss how triggers autophagy, creating feedback loop promotes survival, dysregulation leads increased accumulation, exacerbating tumorigenesis. also examine implications targeting autophagy-oxidative axis cancer. Current strategies involve modulating through specific inhibitors, enhancing levels pro-oxidant compounds, combining these approaches conventional therapies overcome drug Understanding complex relationship provides critical insights into novel aimed at improving treatment outcomes.

Language: Английский

Lipid droplets and cellular lipid flux DOI

Alyssa J. Mathiowetz,

James A. Olzmann

Nature Cell Biology, Journal Year: 2024, Volume and Issue: 26(3), P. 331 - 345

Published: March 1, 2024

Language: Английский

Citations

87
Fat infiltration in skeletal muscle: Influential triggers and regulatory mechanism DOI Creative Commons
Liyi Wang, Teresa G. Valencak, Tizhong Shan

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(3), P. 109221 - 109221

Published: Feb. 15, 2024

Fat infiltration in skeletal muscle (also known as myosteatosis) is now recognized a distinct disease from sarcopenia and directly related to declining capacity. Hence, understanding the origins regulatory mechanisms of fat vital for maintaining development improving human health. In this article, we summarized triggering factors such aging, metabolic diseases syndromes, nonmetabolic diseases, injury that all induce muscle. We discussed recent advances on cellular found several cell types including myogenic cells non-myogenic contribute myosteatosis. Furthermore, reviewed molecular mechanism, detection methods, intervention strategies Based current findings, our review will provide new insight into regulating function lipid metabolism treating muscle-related diseases.

Language: Английский

Citations

42
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK DOI
Yajuan Li, Daniel Muñoz-Mayorga,

Yuhang Nie

et al.

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(6), P. 1351 - 1370.e8

Published: April 23, 2024

Language: Английский

Citations

40
Recent advances in organelle-targeted organic photosensitizers for efficient photodynamic therapy DOI
Musa Dirak, Cansu M. Yenici, Safacan Kölemen

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 506, P. 215710 - 215710

Published: Feb. 20, 2024

Language: Английский

Citations

29
Versatile organic fluorescent probes for visualizing the dynamics of lipid droplets DOI

Mingyue Cao,

Yunting Liu,

Caihong Xiang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216181 - 216181

Published: Sept. 5, 2024

Language: Английский

Citations

22
Fluorescent probes - illuminate the interplay network between lipid droplets and other organelles DOI
Jialu Yang,

Juan Ning,

Pengju Sun

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 510, P. 215792 - 215792

Published: March 28, 2024

Language: Английский

Citations

21
Lipid droplets provide metabolic flexibility for cancer progression DOI Creative Commons
Rémi Safi, Pablo Menéndez, Albert Pol

et al.

FEBS Letters, Journal Year: 2024, Volume and Issue: 598(10), P. 1301 - 1327

Published: Feb. 7, 2024

A hallmark of cancer cells is their remarkable ability to efficiently adapt favorable and hostile environments. Due a unique metabolic flexibility, tumor can grow even in the absence extracellular nutrients or stressful scenarios. To achieve this, need large amounts lipids build membranes, synthesize lipid‐derived molecules, generate energy other nutrients. Tumor potentiate strategies obtain from cells, pathways new lipids, mechanisms for efficient storage, mobilization, utilization these lipids. Lipid droplets (LDs) are organelles that collect supply eukaryotes it increasingly recognized accumulation LDs cells. Furthermore, an active role LD proteins processes underlying tumorigenesis has been proposed. Here, by focusing on three major classes LD‐resident (perilipins, lipases, acyl‐CoA synthetases), we provide overview contribution progression discuss during proliferation, invasion, metastasis, apoptosis, stemness

Language: Английский

Citations

18
Protection Strategies Against Palmitic Acid-Induced Lipotoxicity in Metabolic Syndrome and Related Diseases DOI Open Access
Zeltzin Alejandra Ceja-Galicia, Carlos L. Céspedes, Mohammed El‐Hafidi

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 788 - 788

Published: Jan. 18, 2025

Diets rich in carbohydrate and saturated fat contents, when combined with a sedentary lifestyle, contribute to the development of obesity metabolic syndrome (MetS), which subsequently increase palmitic acid (PA) levels. At high concentrations, PA induces lipotoxicity through several mechanisms involving endoplasmic reticulum (ER) stress, mitochondrial dysfunction, inflammation cell death. Nevertheless, there are endogenous strategies mitigate PA-induced its unsaturation elongation channeling storage lipid droplets (LDs), plays crucial role sequestering oxidized lipids, thereby reducing oxidative damage membranes. While extended exposure promotes reactive oxygen species (ROS) generation leading damage, acute ß-cells increases glucose-stimulated insulin secretion (GSIS), activation free fatty receptors (FFARs). Subsequently, FFARs by exogenous agonists has been suggested as potential therapeutic strategy prevent ß cells. Moreover, some acids, including oleic acid, can counteract negative impact on cellular health, suggesting complex interaction between different dietary fats outcomes. Therefore, challenge is peroxidation unsaturated acids utilization natural antioxidants. This complexity indicates necessity for further research into function diverse pathological conditions find main target against lipotoxicity. The aim this review is, therefore, examine recent data regarding mechanism underlying order identify that promote protection lipotoxicity, dysfunction apoptosis MetS obesity.

Language: Английский

Citations

3
Lipidome disruption in Alzheimer’s disease brain: detection, pathological mechanisms, and therapeutic implications DOI Creative Commons
Sijia He, Ziying Xu, Xianlin Han

et al.

Molecular Neurodegeneration, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 27, 2025

Alzheimer's disease (AD) is among the most devastating neurodegenerative disorders with limited treatment options. Emerging evidence points to involvement of lipid dysregulation in development AD. Nevertheless, precise lipidomic landscape and mechanistic roles lipids pathology remain poorly understood. This review aims highlight significance lipidomics lipid-targeting approaches diagnosis We summarized connection between human brain AD at both genetic species levels. briefly introduced technologies discussed potential challenges areas future advancements field for research. To elucidate central role converging multiple pathological aspects AD, we reviewed current knowledge on interplay major features, including amyloid beta, tau, neuroinflammation. Finally, assessed progresses obstacles lipid-based therapeutics proposed strategies leveraging

Language: Английский

Citations

3
Oxidative Stress and Reprogramming of Lipid Metabolism in Cancers DOI Creative Commons
Siqi Li, Hang Yuan, Liang Li

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 201 - 201

Published: Feb. 10, 2025

Oxidative stress is a common event involved in cancer pathophysiology, frequently accompanied by unique lipid metabolic reprogramming phenomena. caused mainly an imbalance between the production of reactive oxygen species (ROS) and antioxidant system cells. Emerging evidence has reported that oxidative regulates expression activity metabolism-related enzymes, leading to alteration cellular metabolism; this involves significant increase fatty acid synthesis shift way which lipids are taken up utilized. The dysregulation metabolism provides abundant intermediates synthesize biological macromolecules for rapid proliferation cells; moreover, it contributes maintenance intracellular redox homeostasis producing variety reducing agents. Moreover, derivatives metabolites play critical roles signal transduction within cells tumor microenvironment evades immune destruction facilitates invasion metastasis. These findings suggest close relationship during malignant progression cancers. This review focuses on crosstalk reprogramming, in-depth insight into modulation ROS cancers discusses potential strategies targeting therapy.

Language: Английский

Citations

3