The bile acid receptor TGR5 regulates the hematopoietic support capacity of the bone marrow niche DOI Creative Commons
Alejandro Alonso‐Calleja, Alessia Perino, Frédérica Schyrr

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 23, 2023

Abstract The gut is an emerging regulator of bone marrow (BM) hematopoiesis and several signaling molecules are involved in this communication. Among them, bile acids (BAs), originally classified as lipid solubilizers, have emerged powerful that act a relay between the digestive system, microbiota rest body. function BAs relies on specific receptors, including Takeda-G-protein-receptor-5 (TGR5). TGR5 has potent regulatory effects immune cells, but its effect BM primary organ remains unknown. Here, we investigated young mice observed significant reduction adipose tissue (BMAT) upon loss TGR5, accompanied by enrichment adipocyte progenitors which translated into enhanced hematopoietic recovery transplantation. These findings open possibility modulating stromal support acting signaling. Summary This work shows loss-of-function reduces regulated accelerates data highlight key player microenvironment.

Language: Английский

Adipose tissue as a linchpin of organismal ageing DOI
Tammy Nguyen, Silvia Corvera

Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(5), P. 793 - 807

Published: May 23, 2024

Language: Английский

Citations

22
Skeletal stem and progenitor cells in bone physiology, ageing and disease DOI
Seppe Melis, Dana Trompet, Andrei S. Chagin

et al.

Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Language: Английский

Citations

7
Role of joint adipose tissues in osteoarthritis DOI

Natalia Zapata‐Linares,

Françis Berenbaum, Xavier Houard

et al.

Annales d Endocrinologie, Journal Year: 2024, Volume and Issue: 85(3), P. 214 - 219

Published: June 1, 2024

Language: Английский

Citations

5
Neuroimmune Interactions and Their Role in Immune Cell Trafficking in Cardiovascular Diseases and Cancer DOI Open Access
Yutang Wang,

Jack Anesi,

Indu S. Panicker

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2553 - 2553

Published: March 12, 2025

Sympathetic nerves innervate bone marrow and various immune organs, where norepinephrine—the primary sympathetic neurotransmitter—directly interacts with cells that express adrenergic receptors. This article reviewed the key molecular pathways triggered by activation explored how activity influences cell migration. Norepinephrine serves as a chemoattractant for monocytes, macrophages, stem cells, promoting migration of myeloid while inhibiting lymphocytes at physiological concentrations. We also examined role infiltration in cardiovascular diseases cancer. Evidence suggests increases into target tissues across diseases, including atherosclerosis, hypertension, cardiac fibrosis, hypertrophy, arrhythmia, myocardial infarction, heart failure, stroke. Conversely, may serve potential therapeutic strategy to treat these conditions reducing macrophage infiltration. Furthermore, promotes accumulation cancer tissues, mirroring its effects suppressing T lymphocyte cancerous sites. These changes contribute increased growth metastasis. Thus, could help protect against enhancing presence tumors.

Language: Английский

Citations

0
Sex-Specific Characteristics of Perivascular Fat in Aortic Aneurysms DOI Open Access

Katja Heller,

Panagiotis Doukas, Christian Uhl

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(9), P. 3071 - 3071

Published: April 29, 2025

Aortic aneurysms (AAs), the dilation or widening of aorta, lead to dissection rupture with high morbidity and mortality if untreated. AA displays gender disparities in its prevalence, progression outcomes, women having worse outcomes faster aneurysm growth. However, current guidelines do not address dimorphism, emphasizing urgent need for personalized treatment strategies further research. Perivascular adipose tissue (PVAT), a unique type fat surrounding blood vessels, plays critical role maintaining vasomotor tone vascular homeostasis, dysfunction associated chronic inflammation vessel-wall remodeling. Indeed, PVAT promotes development aortic aneurysms, hormonal biomechanical factors exacerbating pathological microenvironment. The sexually dimorphic characteristics include morphological, immunological, hormonally mediated differences. Thus, targeting PVAT-mediated mechanisms may be promising option (gender-specific) therapeutic management cardiovascular pathologies. This review examines emerging importance health, potential implications AA, identifies gaps state

Language: Английский

Citations

0
GPx3 marks adipocyte lineage commitment in bone marrow stromal cells DOI Creative Commons
Zhongxiang Wang, Yang‐Yang Hu, Li Mao

et al.

Journal of Orthopaedic Surgery and Research, Journal Year: 2025, Volume and Issue: 20(1)

Published: May 23, 2025

Bone marrow adipose tissue (BMAT) plays an essential role in skeletal health and systemic metabolism, particularly under conditions of ageing osteoporosis. Despite increasing recognition BMAT as active endocrine organ, the molecular mechanisms underlying its formation expansion remain incompletely understood. We conducted a transcriptomic re-analysis publicly available datasets focused on adipogenic differentiation bone stromal cells (BMSCs). Differential gene expression pathway enrichment analyses were performed to identify key changes. Validation was at both transcript protein levels. Furthermore, single-cell RNA sequencing (scRNA-seq) data employed determine cell type-specific candidate genes within marrow. Functional assays using interference carried out investigate glutathione peroxidase 3 (GPx3) adipogenesis. Our analysis revealed consistent activation oxidative stress-related pathways during differentiation. Among upregulated antioxidant enzymes, GPx3 selectively increased adipogenic-but not osteogenic-differentiation. This pattern validated mRNA levels vitro. scRNA-seq showed that is predominantly localized BMSCs adipocytes, with reduced observed aged mice, corresponding elevated adipocyte-related genes. In vitro functional experiments demonstrated knockdown significantly promoted BMSCs. These findings indicate closely associated adipocyte lineage commitment microenvironment may serve modulator BMSC fate. study underscores potential enzymes such regulation age-related bone-fat imbalance highlights their relevance metabolic disorders.

Language: Английский

Citations

0
Molecular Deconvolution of Bone Marrow Adipose Tissue Interactions with Malignant Hematopoiesis: Potential for New Therapy Development DOI
Drenka Trivanović,

Marko Vujačić,

Rossella Labella

et al.

Current Osteoporosis Reports, Journal Year: 2024, Volume and Issue: 22(4), P. 367 - 377

Published: June 26, 2024

Language: Английский

Citations

1
The bile acid receptor TGR5 regulates the hematopoietic support capacity of the bone marrow niche DOI Open Access
Alejandro Alonso‐Calleja, Alessia Perino, Frédérica Schyrr

et al.

Published: Jan. 24, 2024

The gut is an emerging regulator of bone marrow (BM) hematopoiesis and several signaling molecules are involved in this communication. Among them, bile acids (BAs), originally classified as lipid solubilizers, have emerged powerful that act a relay between the digestive system, microbiota rest body. function BAs relies on specific receptors, including Takeda-G-protein-receptor-5 (TGR5). TGR5 has potent regulatory effects immune cells, but its effect BM primary organ remains unknown. Here, we investigated young mice observed significant reduction adipose tissue (BMAT) upon loss TGR5, accompanied by enrichment adipocyte progenitors which translated into enhanced hematopoietic recovery transplantation. These findings open possibility modulating stromal support acting signaling.This work shows loss-of-function reduces regulated accelerates data highlight key player microenvironment.

Language: Английский

Citations

0
The bile acid receptor TGR5 regulates the hematopoietic support capacity of the bone marrow niche DOI Open Access
Alejandro Alonso‐Calleja, Alessia Perino, Frédérica Schyrr

et al.

Published: Jan. 24, 2024

The gut is an emerging regulator of bone marrow (BM) hematopoiesis and several signaling molecules are involved in this communication. Among them, bile acids (BAs), originally classified as lipid solubilizers, have emerged powerful that act a relay between the digestive system, microbiota rest body. function BAs relies on specific receptors, including Takeda-G-protein-receptor-5 (TGR5). TGR5 has potent regulatory effects immune cells, but its effect BM primary organ remains unknown. Here, we investigated young mice observed significant reduction adipose tissue (BMAT) upon loss TGR5, accompanied by enrichment adipocyte progenitors which translated into enhanced hematopoietic recovery transplantation. These findings open possibility modulating stromal support acting signaling.This work shows loss-of-function reduces regulated accelerates data highlight key player microenvironment.

Language: Английский

Citations

0
The bile acid receptor TGR5 regulates the hematopoietic support capacity of the bone marrow niche DOI Creative Commons
Alejandro Alonso‐Calleja, Alessia Perino, Frédérica Schyrr

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 23, 2023

Abstract The gut is an emerging regulator of bone marrow (BM) hematopoiesis and several signaling molecules are involved in this communication. Among them, bile acids (BAs), originally classified as lipid solubilizers, have emerged powerful that act a relay between the digestive system, microbiota rest body. function BAs relies on specific receptors, including Takeda-G-protein-receptor-5 (TGR5). TGR5 has potent regulatory effects immune cells, but its effect BM primary organ remains unknown. Here, we investigated young mice observed significant reduction adipose tissue (BMAT) upon loss TGR5, accompanied by enrichment adipocyte progenitors which translated into enhanced hematopoietic recovery transplantation. These findings open possibility modulating stromal support acting signaling. Summary This work shows loss-of-function reduces regulated accelerates data highlight key player microenvironment.

Language: Английский

Citations

0