Androgens and Hirsutism in a Large Cohort of Portuguese Women
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(3), P. 673 - 673
Published: Jan. 21, 2025
Background/Objectives:
Hirsutism
is
excessive
male-patterned
hair
in
postpubertal
women
with
multifactorial
etiology
and
an
indicator
of
hyperandrogenism
associated
polycystic
ovary
syndrome
(PCOS).
Indeed,
it
can
be
caused
by
the
enhanced
peripheral
conversion
androgen
precursors
to
testosterone,
as
idiopathic
hirsutism
(IH).
Moreover,
hirsutism-related
hyperandrogenic
syndromes
like
non-classic
congenital
adrenal
hyperplasia
(NCAH)
(IHA).
Methods:
In
this
study,
we
characterized
a
large
cohort
Portuguese
referred
for
estimated
prevalence
PCOS,
NCAH,
IHA,
IH.
The
levels
androgens
gonadotropins
body
mass
index
(BMI)
were
measured
compared
controls.
correlation
between
each
variable
was
calculated.
Results:
cohort,
found
PCOS
56.2%,
IH
20.2%,
IHA
17.3%,
NCAH
6.2%.
Subjects
only
ones
showing
significant
difference
BMI
controls
had
lowest
sex
hormone-binding
globulin
(SHBG).
Those
younger
more
hirsute
higher
among
other
androgens.
lower
luteinizing
hormone
(LH)
LH/follicle-stimulating
(FSH)
ratios
than
those
PCOS.
SHBG
free
(FAI).
IH,
particular,
adrenal-derived
Conclusions:
pathogenesis
complex,
contributions
pituitary
gland,
ovaries,
adrenals,
adipose
tissue,
liver
have
ascertained
understand
clinical
manifestations
delineate
appropriate
treatments.
This
study
sheds
new
light
on
fine
hormonal
regulation
these
diseases.
Language: Английский
Gut Microbiota Modulation by Inulin Improves Metabolism and Ovarian Function in Polycystic Ovary Syndrome
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 7, 2025
Abstract
The
management
of
metabolic
disorder
associated
with
polycystic
ovary
syndrome
(PCOS)
has
been
suggested
as
an
effective
approach
to
improve
PCOS
which
is
highly
involved
gut
microbiota,
while
the
underlying
mechanism
unclear.
Here,
we
investigated
role
inulin,
a
microbiota
regulator,
in
alleviation
PCOS.
Our
findings
showed
that
inulin
treatment
significantly
improved
hyperandrogenism
and
glucolipid
metabolism
both
cohort
mice.
Consistent
cohort,
increased
abundance
microbial
co‐abundance
group
(CAG)
12
mice,
including
Bifidobacterium
species
other
short‐chain
fatty
acids
(SCFAs)‐producers.
We
further
verified
enhancement
SCFAs
biosynthesis
capacity
fecal
content
by
inulin.
Moreover,
decreased
lipopolysaccharide‐binding
protein
(LBP)
ameliorated
ovarian
inflammation
whereas
intraperitoneal
lipopolysaccharide
(LPS)
administration
reversed
protective
effects
Furthermore,
transplantation
(FMT)
from
inulin‐treated
patients
enhanced
insulin
sensitivity,
lipid
accumulation
thermogenesis,
reduced
inflammatory
response
antibiotic‐treated
Collectively,
these
revealed
mediates
beneficial
on
dysfunction
Therefore,
modulating
represents
promising
therapeutic
strategy
for
Language: Английский