medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2020,
Volume and Issue:
unknown
Published: April 25, 2020
SUMMARY
The
COVID-19
pandemic
is
spreading
globally
with
high
disparity
in
the
susceptibility
of
disease
severity.
Identification
key
underlying
factors
for
this
highly
warranted.
Here
we
describe
constructing
a
proteomic
risk
score
based
on
20
blood
biomarkers
which
predict
progression
to
severe
COVID-19.
We
demonstrate
that
our
own
cohort
990
individuals
without
infection,
positively
associated
proinflammatory
cytokines
mainly
among
older,
but
not
younger,
individuals.
further
discovered
core
set
gut
microbiota
could
accurately
above
301
using
machine
learning
model,
and
these
features
are
correlated
another
366
Fecal
metabolomic
analysis
suggested
potential
amino
acid-related
pathways
linking
inflammation.
This
study
suggests
may
underlie
predisposition
normal
Molecular Cancer,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: Nov. 21, 2024
Metabolic
alterations,
a
hallmark
of
cancer,
enable
tumor
cells
to
adapt
their
environment
by
modulating
glucose,
lipid,
and
amino
acid
metabolism,
which
fuels
rapid
growth
contributes
treatment
resistance.
In
primary
breast
metabolic
shifts
such
as
the
Warburg
effect
enhanced
lipid
synthesis
are
closely
linked
chemotherapy
failure.
Similarly,
metastatic
lesions
often
display
distinct
profiles
that
not
only
sustain
but
also
confer
resistance
targeted
therapies
immunotherapies.
The
review
emphasizes
two
major
aspects:
mechanisms
driving
in
both
how
unique
environments
sites
further
complicate
treatment.
By
targeting
vulnerabilities
at
stages,
new
strategies
could
improve
efficacy
existing
provide
better
outcomes
for
cancer
patients.
Metabolism Open,
Journal Year:
2025,
Volume and Issue:
25, P. 100347 - 100347
Published: Jan. 9, 2025
The
highly
nuanced
transition
from
an
inflammatory
process
to
tumorigenesis
is
of
great
scientific
interest.
While
it
well
known
that
environmental
stimuli
can
cause
inflammation,
less
about
the
oncogenic
modifications
chronic
inflammation
in
tissue
microenvironment
bring
about,
as
how
these
set
off
pro-tumorigenic
processes.
It
clear
no
matter
where
factors
come
from,
maintaining
encourages
carcinogenesis.
In
addition
encouraging
angiogenesis
and
metastatic
processes,
sustaining
survival
proliferation
malignant
transformed
cells,
possibly
altering
efficacy
therapeutic
agents,
negatively
regulate
antitumoral
adaptive
innate
immune
responses.
Because
has
multiple
pathways
involved
metastasis,
gained
recognition
a
marker
cancer
desirable
target
for
therapy.
Recent
advances
our
knowledge
molecular
mechanisms
drive
cancer's
progression
demonstrate
promotes
metastasis
while
suppressing
anti-tumor
immunity.
many
solid
tumor
types,
including
breast,
lung,
liver
cancer,
stimulates
activation
oncogenes
impairs
body's
defenses
against
tumor.
Additionally,
alters
As
tactical
approach
treatment,
findings
have
underscored
importance
targeting
pathways.
This
review
highlights
role
development
focusing
on
its
impact
progression,
suppression,
therapy
resistance.
examines
current
anti-inflammatory
strategies,
NSAIDs,
cytokine
modulators,
STAT3
inhibitors,
addressing
their
potential
limitations.
emphasizes
need
further
research
unravel
complex
linking
identify
targets
specific
subtypes.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2020,
Volume and Issue:
unknown
Published: April 25, 2020
SUMMARY
The
COVID-19
pandemic
is
spreading
globally
with
high
disparity
in
the
susceptibility
of
disease
severity.
Identification
key
underlying
factors
for
this
highly
warranted.
Here
we
describe
constructing
a
proteomic
risk
score
based
on
20
blood
biomarkers
which
predict
progression
to
severe
COVID-19.
We
demonstrate
that
our
own
cohort
990
individuals
without
infection,
positively
associated
proinflammatory
cytokines
mainly
among
older,
but
not
younger,
individuals.
further
discovered
core
set
gut
microbiota
could
accurately
above
301
using
machine
learning
model,
and
these
features
are
correlated
another
366
Fecal
metabolomic
analysis
suggested
potential
amino
acid-related
pathways
linking
inflammation.
This
study
suggests
may
underlie
predisposition
normal
